Bafilomycin A1, (V)-ATPase inhibitor ab120497 from Abcam

Product Specs
ItemBafilomycin A1, (V)-ATPase inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120497
Quantity10 µg, 100 µg
Purity0.98
TypeInhibitor, inhibitor
Molecule Namebafilomycin A1

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Website: http://www.abcam.com

(1) Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti‐Resorptive TherapyAdvanced ScienceDecember 7, 2025Hang Zhang, Xin Shen, Haiyang Liu, Xinxi Yuan, Mumin Cao, Xuepeng Lv, Ziji Ling, Songsong Guo, Rongyao Xu, Xiang Li, et al.available in the NCBI GEO under accession number GSE306512. Activators and Inhibitors Baf A1 (Abcam, ab120497) was applied as a selective vacuolar (V)‐ATPase inhibitor at a working concentration of 10 nm. RAPA

(2) Reprogramming oncogenic mitochondria in pancreatic adenocarcinoma through BRD4 inhibition leads to programmed cell deathThe Journal of Pharmacology and Experimental TherapeuticsNovember 1, 2025Chun Cai, Michael W. Spinrad, Lauren C. Gattie, Rui Wang, Mohammad Amir Afjal, Jun Yang, Nour Yadak, David Shibata, Wei Li, Amandeep Bajwa, et al.from Selleckchem (#S1149), and Bafilomycin A1 and the (V)-ATPase inhibitor were purchased from Abcam (#ab120497). 2.3 Cell transfection Small interfering RNAs (siRNAs) were used to knockdown the expression of BRD4.

(3) Chlorogenic acid modulates mitochondrial damage and mitophagy to repair injured myocardial tissue and cellsFront PharmacolOctober 1, 2025Hao Ling, Yu Zhang, Chunli Songco-treatment with 200 µM H2O2 and 200 μg/mL OLEU, cells were exposed to 100 nM bafilomycin A1 (BafA1) (Abcam, ab120497) for an additional 4 h; control groups received no treatment. After the treatment, both the cells and

(4) The proteostatic landscape of healthy human oocytesThe EMBO JournalJuly 16, 2025Gabriele Zaffagnini, Miquel Solé, Juan Manuel Duran, Nikolaos P Polyzos, Elvan Böke,Thermo Fisher,L12492 TMRE,Thermo Fisher,T669 Me4Bpy,Bio-Techne,I-190-050 Verapamil,Spirochrome,n/a Bafilomycin A1,Abcam,ab120497 MG-132,Merck Millipore,474790 CCCP,Abcam,ab141229 Proteostat,Enzo,ENZ-51035-K100 Software,Software,Software FIJI,ImageJ.net,2.14.04/1.54f Prism

(5) Etoposide-induced protein 2.4 homolog promotes argininosuccinate synthase 1 and cancer cell survival upon arginine deprivationCell Mol Biol LettApril 19, 2025Vu T. A. Vo, Le Nhat Tran, Thu Thanh Bui, Han-Woong Lee, Yangsik Jeongmethylester (L-NAME, sc-200333) and deferoxamine (sc-203331) were from Santa Cruz. Bafilomycin A1 (Baf, ab120497) was from Abcam. Adenovirus, plasmids, and transfection TOPO™ cloning was performed to produce EI24-expressing

(6) α-hederin decreases the glycolysis level in intestinal epithelial cells via SNX10-mediated DEPDC5 degradationJournal of Pharmaceutical AnalysisApril 12, 2025Hui Feng, Jin Wang, Lihuiping Tao, Liu Li, Minmin Fan, Chengtao Yu, Dongdong Sun, Haibo Cheng, Weixing Shendissolved in dimethyl sulfoxide (DMSO) to indicated concentrations. MG-132 (ab141003) and bafilomycinA1 (ab120497) were supplied by Abcam (Cambridge, UK). Rapamycin (HY-10219), cycloheximide (HY-12320), chloroquine

(7) Reversing protonation of weakly basic drugs greatly enhances intracellular diffusion and decreases lysosomal sequestrationElifeDecember 6, 2024Debabrata Dey, Shir Marciano, Anna Poryval, Ondřej Groborz, Lucie Wohlrabova, Tomás Slanina, Gideon Schreibercompound, drug",Mitoxantrone,Abcam,Cat# ab141041, "Chemical compound, drug",Bafilomycin A1,Abcam,Cat# ab120497, "Chemical compound, drug",5-amino Fluorescein,Abcam,Cat#ab145305,

(8) Reversing protonation of weakly basic drugs greatly enhances intracellular diffusion and decreases lysosomal sequestrationeLifeDecember 6, 2024Debabrata Dey, Shir Marciano, Anna Poryval, Ondřej Groborz, Lucie Wohlrabova, Tomás Slanina, Gideon Schreibercompound, drug",Mitoxantrone,Abcam,Cat# ab141041, "Chemical compound, drug",Bafilomycin A1,Abcam,Cat# ab120497, "Chemical compound, drug",5-amino Fluorescein,Abcam,Cat#ab145305,

(9) FOXO1‐NCOA4 Axis Contributes to Cisplatin‐Induced Cochlea Spiral Ganglion Neuron Ferroptosis via FerritinophagyAdvanced ScienceOctober 1, 2024Xue Wang, Lei Xu, Yu Meng, Fang Chen, Jinzhu Zhuang, Man Wang, Weibin An, Yuechen Han, Bo Chu, Renjie Chai, et al.µM; Selleck, S7242), deferoxamine (DFO, 80 µM; Selleck, S5742), bafilomycin A1 (Baf, 100 nM; Abcam, ab120497), and rapamycin (RAP, 0.1 µM; Abcam, ab120224). After the culture period, the samples were collected

(10) USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapyCell death and differentiationMay 1, 2024Young MJ, Wang SA, Chen YC, Liu CY, Hsu KC, Tang SW, Tseng YL, Wang YC, Lin SM, Hung JJ.μM USP24-i-101, 24 nM Taxol (paclitaxel, Selleckchem, S1150), 10 nM Baf-A1 (Bafilomycin A1, Abcam, ab120497), and 5 μM CQ (Chloroquine, MedChem Express, HY-17589A) for 24 h. The cell viability was assessed using

(11) BCAA metabolism in pancreatic cancer affects lipid balance by regulating fatty acid import into mitochondriaCancer MetabMarch 26, 2024Klára Gotvaldová, Jitka Špačková, Jiří Novotný, Kamila Baslarová, Petr Ježek, Lenka Rossmeislová, Jan Gojda, Katarína Smolková3-Methyladenin, MERCK M9281, final concentration 1 mMBafA, autolysosome formation inhibitor Bafilomycin A1, Abcam ab120497, final concentration 100 nMCQ, autolysosome formation inhibitor chloroquine, MERCK C6628, final concentration

(12) Selective degradation of hyperphosphorylated tau by proteolysis-targeting chimeras ameliorates cognitive function in Alzheimer's disease model miceFrontiers in pharmacologyJanuary 1, 2024Yao D, Li T, Yu L, Hu M, He Y, Zhang R, Wu J, Li S, Kuang W, Yang X, et al.MG132 (MedChemExpress, HY-13259), okadaic acid (OA; Millipore, 19-130), and bafilomycin A1 (Abcam, ab120497) were dissolved in 99.7% DMSO (Sigma-Aldrich, D2650). We also used cycloheximide (CHX; MedChemExpress,

(13) Proteopathy Linked to Exon-Skipping Isoform of RGR-Opsin Contributes to the Pathogenesis of Age-Related Macular DegenerationInvestigative ophthalmology & visual scienceOctober 3, 2023Ren C, Cui H, Bao X, Huang L, He S, Fong HKW, Zhao M.autophagy flux, we treated the cells with 2 µM MG132 combined with or without 50 nM bafilomycin A1 (BafA1) (ab120497; Abcam) for 12 hours. For investigations of ER stress and unfolded protein response (UPR) pathways,

(14) HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress-driven hepatocellular carcinoma progressionCancer communications (London, England)September 1, 2023He L, Li H, Li C, Liu ZK, Lu M, Zhang RY, Wu D, Wei D, Shao J, Liu M, et al.μmol/L tauroursodeoxycholate (TUDCA; HY‐19696, MedChemExpress) or 50 nmol/L bafilomycin A1 (Baf A1; ab120497, Abcam). The reagents were dissolved in dimethyl sulfoxide (DMSO; D2650, Sigma) and further diluted

(15) Inhibition of HDAC6 promotes microvascular endothelial cells to phagocytize myelin debris and reduces inflammatory response to accelerate the repair of spinal cord injuryCNS Neuroscience & TherapeuticsAugust 29, 2023Chengjie Wu, Yalan Pan, Lining Wang, Mengmin Liu, Pengcheng Tu, Sixian Chen, Lei Shi, Danqing Yan, Yong Ma, Yang Guowith 40 μM Tubastatin‐A, while MECs of the Baf‐A1 group were treated with 50 nM bafilomycin A1 (Abcam, ab120497). 16 These indices were measured after 72 h. 2.7 Transwell cultures MECs and myelin debris were cocultured

(16) Diosgenin Targets CaMKK2 to Alleviate Type II Diabetic Nephropathy through Improving Autophagy, Mitophagy and Mitochondrial DynamicsNutrientsAugust 11, 2023Zhong Y, Jin R, Luo R, Liu J, Ren L, Zhang Y, Shan Z, Peng X.5142-23-4, catalog number: ab120841) and Bafilomycin A1 (Baf-A1, CAS#: 88899-55-2, catalog number: ab120497) were purchased from Abcam (St. Louis, MO, USA). Diosgenin (DIO, CAS#: 512-06-1) was purchased from

(17) Role of heat shock protein 90 as an antiviral target for swine enteric coronavirusesVirus ResearchMay 1, 2023Zhuangzhuang Zhao, Ya-Qing Zhang, Ling-Dong Xu, Lihua Xiao, Yaoyu Feng, Bin Wang, Yao-Wei Huangpurchased from Selleck Chemicals. 3-methyladenine (HY-19,312) was purchased from MCE. Bafilomycin A1 (ab120497) was purchased from Abcam. Chloroquine (CAS 50–63–5), PMA (P1585), and nigericin (481,990) were purchased

(18) Heat shock protein 90 facilitates SARS-CoV-2 structural protein-mediated virion assembly and promotes virus-induced pyroptosisJournal of Biological ChemistryMay 1, 2023Zhuangzhuang Zhao, Ling-Dong Xu, Fei Zhang, Qi-Zhang Liang, Yajuan Jiao, Fang-Shu Shi, Biao He, Pinglong Xu, Yao-Wei Huang(HY-19312) and VER-155008 (HY-10941) were purchased from MedChemExpress (shanghai, China). Bafilomycin A1 (ab120497) was purchased from Abcam. Chloroquine (CAS 50-63-5), PMA (P1585), Nigericin (481990), LPS (L2630) were

(19) Xanthatin suppresses proliferation and tumorigenicity of glioma cells through autophagy inhibition via activation of the PI3K-Akt-mTOR pathwayPharmacology research & perspectivesFebruary 1, 2023Chen H, Zhu T, Huang X, Xu W, Di Z, Ma Y, Xue M, Bi S, Shen Y, Yu Y, et al.(Invitrogen, A11036). The following reagents were used: autophagy inhibitor bafilomycin A1 (Baf A1)(Abcam, AB120497), autophagy inducers Torin1 (Selleckchem, S2827), and rapamycin (Rapa) (Santa Cruz, sc‐3504), PI3K/mTOR

(20) Convergence of secretory, endosomal, and autophagic routes in trans-Golgi–associated lysosomesJournal of Cell BiologyJanuary 2, 2023Lingjian Zhou, Xutong Xue, Ke Yang, Zhi Feng, Min Liu, José C. Pastor-Parejafeeding larvae were incubated at RT in Schneider’s Drosophila medium containing 2 μM Bafilomycin A (cat# ab120497; Abcam), 15 mg/ml chloroquine (cat# ab142116; Abcam), 0.25 mg/ml Cytochalasin D (cat# PHZ1063; Invitrogen),

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Bafilomycin A1, (V)-ATPase inhibitor from Abcam

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Bafilomycin A1, (V)-ATPase inhibitor from Abcam

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