Phospho-Bcl-2 (Ser70) (5H2) Rabbit mAb 2827L from Cell Signaling Technology

Product Specs
ItemPhospho-Bcl-2 (Ser70) (5H2) Rabbit mAb
CompanyCell Signaling Technology
Price $947.00 Inquire
Catalog Number2827L
Quantity300 µl
ApplicationsW, FC-FP
ReactivityH
TargetBcl-2 (Ser70) phosphate
ModificationsBcl-2 (Ser70) phosphate
HostRabbit
NCBI Gene AliasesBcl-2, PPP1R50
ClonalityMonoclonal
NCBI Full Gene NameBCL2 apoptosis regulator
Research AreaApoptosis
Clone5H2
Molecular Weight28

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) QW-5-70 targets the colchicine site and demonstrates antitumor activity in P-gp-overexpressing cancer modelsMol Cancer TherApril 22, 2026Yang Xie, Ruida Hou, Najah Albadari, Hao Chen, Darcie J. Miller, Judith Quadrozzi Quadrozzi Gruntz, Michael L. Oldham, Mir Shahriar Kamal, Jianxiong Jiang, Zhongzhi Wu, et al.phospho-Histone H3 (CST, #9701, RRID: AB_331535), HistoneH3 (CST, #4499, RRID: AB_10544537), phospho-Bcl-2 (CST, #2827, RRID: AB_659950), MDR1/ABCB1 (P-gp) (CST, #13342, RRID: AB_2631176), MRP1/ABCC1 (CST, #72202, RRID:

(2) Inhibition of pro-apoptotic UPR pathways PERK/CHOP and IRE1/JNK protects differentiated SH-SY5Y cells against rotenone-induced toxicityFront Mol NeurosciDecember 3, 2025Natalia Siwecka, Wioletta Rozpȩdek-Kamińska, Michał Golberg, Wojciech Wiese, Grzegorz Galita, Ireneusz Majsterekantibody,1:500,#9251 Bcl-2 (D55G8) rabbit mAb,"1:1,000",#4223 Phospho-Bcl-2 (Ser70) (5H2) rabbit mAb,1:500,#2827 β-Actin (13E5) rabbit mAb,"1:1,000",#4970 "Anti-rabbit IgG, HRP-linked antibody","1:5,000",#7074 The

(3) Molecular Expression Differences in Specific Blood Mononuclear Cell-Types Identify Patients With AL AmyloidosisJournal of cellular and molecular medicineSeptember 1, 2025Kaplan D, Christian E, Valent J, Anwer F, Mazzoni S, Samaras C, Williams L, Nakashima M, Raza S, Hanna M, et al.Technology (Danvers, MA) with specificities for phospho‐Atg14 ser29 (cat#92340), phospho‐Bcl2 ser70 (#2827), phospho‐cJun ser73 (#3270), phospho‐RelA ser536 (#3033), phospho‐p38 MAPK Thr180/Tyr182 (#9215), phospho‐Erk1/2

(4) Signalling Network Analysis of Blood Mononuclear Cells From Clinical Samples by Bivariate CorrelationJournal of cellular and molecular medicineJune 1, 2025Kaplan D, Lazarus HM, Valent J, Anwer F, Mazzoni S, Samaras C, Williams L, Nakashima M, Hanna M, Raza S, et al.thr202/tyr204 (cat#9101), phospho‐ZAP70 tyr493/phospho‐Syk tyr526 (cat#2704) and phospho‐Bcl2 ser70 (cat#2827) were obtained from Cell Signaling Technology. An antibody specific for Bax (cat#PA5‐11378) was obtained

(5) A self-activated and protective module enhances the preclinical performance of allogeneic anti-CD70 CAR-T cellsFrontiers in ImmunologyJanuary 17, 2025Zhao Zhang, Lianfeng Zhao, Tinghui Huang, Zhengliang Chen, Yaoyao Zhao, Junqing Liang, Xudong Ao, Xiaoqiong Jia, Lei Kang, Linghui Kong, et al.antibodies from Cell Signaling Technology, including phospho-STAT5 (Tyr694; #9359), phospho-BCL2 (Ser70; #2827), and β-Actin (#93473). After washing, the membrane was incubated with a secondary antibody for 1 hour,

(6) Proapoptotic role of CDK1 in overcoming paclitaxel resistance in ovarian cancer cells in response to combined treatment with paclitaxel and duloxetineCancer Cell InternationalDecember 19, 2024Gyeongmi Kim, Se-Kyeong Jang, Se Hee Ahn, Selim Kim, Chan Sub Park, Min-Ki Seong, Hyun-Ah Kim, Seunghee Bae, Jae Ho Lee, Hyunggee Kim, et al.The following antibodies were used: Cleaved PARP (#9541, Cell Signaling Technology), p-Bcl-2 (S70) (#2827, Cell Signaling Technology), Bcl-2 (#A19693, ABclonal, Wuhan, Hubei, China), p-Bcl-xL (S62) (#AP0314,

(7) Biological activity of a stable 6-aryl-2-benzoyl-pyridine colchicine-binding site inhibitor, 60c, in metastatic, triple-negative breast cancerCancer LettersAugust 10, 2024Damilola Oluwalana, Kelli L. Adeleye, Raisa I. Krutilina, Hao Chen, Hilaire Playa, Shanshan Deng, Deanna N. Parke, John Abernathy, Leona Middleton, Alexandra Cullom, et al.to primary antibodies against cleaved-PARP, phosphorylated BCL2, or cleaved caspase-3 (CST #5625, #2827, #9661) at 4°C overnight. After washing, membranes were incubated with anti-rabbit whole IgG secondary

(8) Third-generation taxanes SB-T-121605 and SB-T-121606 are effective in pancreatic ductal adenocarcinomaiScienceFebruary 16, 2024Tomas Sychra, Alzbeta Spalenkova, Stepan Balatka, Radka Vaclavikova, Karolina Seborova, Marie Ehrlichova, Jaroslav Truksa, Cristian Sandoval-Acuña, Vlasta Nemcova, Arpad Szabo, et al.Cell Signaling), PARP (dilution 1:750, #9542, Cell Signaling), phospho-Bcl-2 (Ser70) (dilution 1:400, #2827, Cell Signaling) and actin (dilution 1:1500, clone AC-40, A4700, Sigma-Aldrich). After washing, the

(9) Suppresses of LIM kinase 2 promotes radiosensitivity in radioresistant non-small cell lung cancer cellsHeliyonNovember 8, 2023Chao Tian, Zhen Peng, Lei Chang, Xinzhou Deng, Shan Jiang, Jiahui Han, Can Ye, Yutao Yan, Zhiguo Luoanti-N-cadherin (A19083) were purchased from ABclonal (Abclonal Technology Co., Ltd., China). Rabbit anti-p-BCL2 (2827) and BCL2 (4223) were purchased from CST (Cell Signaling Technology, Inc., USA) and a Ribo Transfection

(10) Targeted inhibition of protein synthesis renders cancer cells vulnerable to apoptosis by unfolded protein responseCell Death & DiseaseAugust 26, 2023Franziska Gsottberger, Christina Meier, Anna Ammon, Scott Parker, Kerstin Wendland, Rebekka George, Srdjan Petkovic, Lisa Mellenthin, Charlotte Emmerich, Gloria Lutzny-Geier, et al.Antibodies used recognized ATF4 (#11815), BAK (#12105), BAX (#89477), BCL-2 (#15071), phospho-BCL-2 (#2827), BCL-XL (#2764), BID (#2002), BiP (#3177), CHOP (#2895), IRE1α (#3294), phospho-JNK (#4668), MCL-1

(11) Involvement of Both Extrinsic and Intrinsic Apoptotic Pathways in Tridecylpyrrolidine-Diol Derivative-Induced Apoptosis In VitroInternational Journal of Molecular SciencesJuly 20, 2023Natalia Nosalova, Alexandra Keselakova, Martin Kello, Miroslava Martinkova, Dominika Fabianova, Martina Bago Pilatova,Phospho-Bad (Ser136) Antibody,23,Rabbit,1:1000,#9295 "Cell Signaling Technology®,Danvers, MA, USA",Phospho-Bcl-2 (Ser70) (5H2) Rabbit mAb,28,Rabbit,1:1000,#2827 "Cell Signaling Technology®,Danvers, MA, USA",Bcl-xL (54H6) Rabbit mAb,30,Rabbit,1:1000,#2764 "Cell Signaling Technology

(12) Marine Polyether Phycotoxin Palytoxin Induces Apoptotic Cell Death via Mcl-1 and Bcl-2 DownregulationMarine drugsApril 6, 2023Kim J, Ji S, Lee JY, Lorquin J, Orlikova-Boyer B, Cerella C, Mazumder A, Muller F, Dicato M, Detournay O, et al.anti-Caspase-9 (1/1000, 9502), anti-Mcl-1 (1/1000, 4572), anti-BID (1/1000, 2002), anti-pBcl-2 ser70 (1/2000, 2827) (all Cell Signaling Technologies, Koram Biotech Corporation, Seoul, Republic of Korea). All antibodies

(13) Spermatogenesis associated serine rich 2 like plays a prognostic factor and therapeutic target in acute myeloid leukemia by regulating the JAK2/STAT3/STAT5 axisJournal of translational medicineFebruary 11, 2023Li F, Ye W, Yao Y, Wei W, Lin X, Zhuang H, Li C, Li X, Ling Q, Hu C, et al.system. Antibodies against GAPDH #8884, STAT3 #4904, STAT5 #94205S, Phospho-STAT5 #9359, Phospho-BCL2 #2827S, Caspase3 #9662S, PARP #9532S were purchased from CST (Danvers, MA). Antibodies against SPATS2L 16938-1-AP,

(14) Selective Induction of Intrinsic Apoptosis in Retinoblastoma Cells by Novel Cationic Antimicrobial DodecapeptidesPharmaceuticsNovember 18, 2022Vishnu Suresh Babu, Atish Kizhakeyil, Gagan Dudeja, Shyam S. Chaurasia, Veluchami Amutha Barathi, Stephane Heymans, Navin Kumar Verma, Rajamani Lakshminarayanan, Arkasubhra Ghosh(Ser139) (1:1000, cat#2577, Cell Signaling Technology, Danvers, MA, USA), p-BCL2(Ser70) (1:1000, cat#2827, Cell Signaling Technology, Danvers, MA, USA), BCL2 (1:1000, cat#2872, Cell Signaling Technology, Danvers,

(15) Sabizabulin, a Potent Orally Bioavailable Colchicine Binding Site Agent, Suppresses HER2+ Breast Cancer and MetastasisCancers (Basel)October 29, 2022Raisa I. Krutilina, Kelli L. Hartman, Damilola Oluwalana, Hilaire C. Playa, Deanna N. Parke, Hao Chen, Duane D. Miller, Wei Li, Tiffany N. SeagrovesSignal from cleaved-PARP (anti-cleaved-PARP, CST 5625, 1:1000), phosphorylated BCL2 (pBCL2; anti-pBCL2, 2827 CST 1:1000) and cleaved caspase-3 (CST 9661, 1:500) was first normalized to β-actin (CST 3700, 1:20,000)

(16) Inhibition of p38 MAPK or immunoproteasome overcomes resistance of chronic lymphocytic leukemia cells to Bcl-2 antagonist venetoclaxCell death & diseaseOctober 8, 2022Avsec D, Škrlj Miklavčič M, Burnik T, Kandušer M, Bizjak M, Podgornik H, Mlinarič-Raščan I.p-ERK1/2 (Thr202/Tyr204) (#9101), CREB (#9197), p-CREB (Ser133) (#9191), Bcl-2 (#15071), p-Bcl-2 (#2827) Bcl-xL (#2764), Bid (#2002), Puma (#12450), Bax (#2772), Bak (#12105), and Mcl-1 (#94296) were from

(17) Anticolon Cancer Effect of Korean Red Ginseng via Autophagy- and Apoptosis-Mediated Cell DeathNutrientsAugust 29, 2022Kang KA, Yao CW, Piao MJ, Zhen AX, Fernando PDSM, Herath HMUL, Song SE, Cho SJ, Hyun JW.Santa Cruz Biotechnology (Santa Cruz, CA, USA). The LC3 (cat. 2775), Beclin-1 (cat. 3738), and phospho-Bcl-2 (cat. 2827) antibodies were purchased from Cell Signaling Technology (Beverly, MA, USA). Dihydrorhodamine (DHR)

(18) Inhibition of Glutamine Uptake Resensitizes Paclitaxel Resistance in SKOV3-TR Ovarian Cancer Cell via mTORC1/S6K Signaling PathwayInternational journal of molecular sciencesAugust 6, 2022Kim G, Jang SK, Kim YJ, Jin HO, Bae S, Hong J, Park IC, Lee JH.(S2448) (#2971), S6K (#9202), p-S6K (Thr389) (#9205), S6 (#2217), p-S6 (Ser240/244) (#5364), p-Bcl-2 (#2827), Bcl-2 (#150071), Bcl-XL (#2764), Bax (#2772), p-Bad (#5284), Bad (#9292), Bid (#2002), Bak (#12105),

(19) Natural history of a mouse model of X-linked myotubular myopathyDisease models & mechanismsJuly 1, 2022Sarikaya E, Sabha N, Volpatti J, Pannia E, Maani N, Gonorazky HD, Celik A, Liang Y, Onofre-Oliveira P, Dowling JJ.T6793, Sigma-Aldrich), anti-α-tubulin (1:1000; 2144, Cell Signaling Technology) and anti-MTM1 (Clone 2827, Dr Jocelyn Laporte, IGBMC). Secondary antibodies used were horseradish peroxidase-conjugated goat anti-rabbit

(20) Selective inhibition of JNK located on mitochondria protects against mitochondrial dysfunction and cell death caused by endoplasmic reticulum stress in mice with LPS‑induced ALI/ARDSInternational journal of molecular medicineJune 1, 2022Li C, Ma D, Chen Y, Liu W, Jin F, Bo L.sc-398822, Santa Cruz Biotechnology, Inc.), anti-phospho-Bcl-2 (Ser70) rabbit mAb (1:1,000, cat. no. 2827, Cell Signaling Technology, Inc.) and anti-cleaved caspase-3 (1:1,000, cat. no. 9664, Cell Signaling Technology

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Phospho-Bcl-2 (Ser70) (5H2) Rabbit mAb

Phospho-Bcl-2 (Ser70) (5H2) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Phospho-Bcl-2 (Ser70) (5H2) Rabbit mAb from Cell Signaling Technology

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