JMJD2B (D7E6) Rabbit mAb 8639S from Cell Signaling Technology

Product Specs
ItemJMJD2B (D7E6) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number8639S
Quantity100 µl
ApplicationsW, IP, IF-IC
ReactivityH, Mk
TargetJMJD2B
HostRabbit
NCBI Gene AliasesJMJD2B, MRD65, TDRD14B
ClonalityMonoclonal
NCBI Full Gene Namelysine demethylase 4B
Research AreaChromatin Regulation / Nuclear Function
IsotypeIgG
CloneD7E6
Molecular Weight150

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) The Lysine Demethylase KDM4C Is an Oncogenic Driver and Regulates ERK Activity in KRAS-Mutant Pancreatic Ductal AdenocarcinomaCancer Res CommunJanuary 1, 2026Menna-t-Allah Shaheen, Sarah Dhebat, Kimal I. Rajapakshe, Bidyut Ghosh, Benson Chellakkan Selvanesan, Shariq S. Ansari, Cara L. Haymaker, Dorsay Sadeghian, Huamin Wang, Ching-Fei Li, et al.Cell Signaling Technology, cat. #5328, RRID: AB_10828595), anti-KDM4B (1:1,000; Cell Signaling Technology, cat. #8639, RRID: AB_11140642), anti-KDM4D (1:1,000; Santa Cruz Biotechnology, cat. #sc-393750, RRID: AB_3674229),

(2) KDM4B modulates ERα signaling pathway to participate in vascular smooth muscle cell calcificationCell Death DiscovOctober 7, 2025Fei Liu, Yang Lv, Yanxia Lin, Chunyu Wang, Shengli Wang, Kai Zeng, Baosheng Zhou, Lin Lin, Jianwei Feng, Ge Sun, et al.following antibodies were used in this study: anti-KDM4B (Cell Signaling Technology, Danvers, MA, USA, #8639), anti-KDM4B (ABclonal, Woburn, MA, USA, #A6670), anti-ERα (Cell Signaling Technology, #D8H8), anti-Gas6

(3) KDM4B enhances immune surveillance via demethylating cGASCell Death DisJuly 1, 2025Qiao Peng, Huimin Zhuo, Minkang Wu, Yun Hao, Yiyi Zhang, Yuying Zheng, Lei Yu, Lin Han, Hui Ren, Yingcong Wang, et al.resource,Source,Identifier Anti-TREX1,Santa Cruz,Cat# sc-271870 Anti-JMJD2B (D7E6),Cell Signaling Technology,Cat# 8639 Anti-phospho-TBK1 (Ser172) (D52C2) XP Rabbit mAb,Cell Signaling Technology,Cat# 5483 Anti-phospho-STING

(4) Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repairScience advancesMarch 14, 2025Chiang JC, Shang Z, Rosales T, Cai L, Chen WM, Cai F, Vu H, Minna JD, Ni M, Davis AJ, et al.RRID:AB_2133202 Proteintech), anti-KDM4A (5328, RRID:AB_10828595, Cell Signaling Technology), anti-KDM4B (8639, RRID:AB_11140642, Cell Signaling Technology), anti–Myc tag (2276, RRID:AB_331783, Cell Signaling Technology),

(5) Targeting KDM4 family epigenetically triggers antitumour immunity via enhancing tumour-intrinsic innate sensing and immunogenicityClinical and translational medicineFebruary 1, 2024Sun M, Han X, Li J, Zheng J, Li J, Wang H, Li X.were downloaded from the company's website. IHC staining was performed using antibodies against KDM4B (8639S; Cell Signalling Technology), and the intensity of KDM4B staining was quantified and scored. To ensure

(6) Histone demethylase KDM4B accelerates the progression of glioblastoma via the epigenetic regulation of MYC stabilityClin EpigeneticsDecember 13, 2023Zhongze Wang, Huarui Cai, Zekun Li, Wei Sun, Erhu Zhao, Hongjuan Cuiprevious article [24]. The following antibodies were used in this experiment: antibodies against KDM4B (8639S), cyclin B1(CCNB1) (4135S), and Flag (14793S) were purchased from CST. Antibodies against MYC (10,828–1-AP),

(7) Intermittent hypoxia enhances the expression of hypoxia inducible factor HIF1A through histone demethylationThe Journal of biological chemistryNovember 1, 2022Martinez CA, Jiramongkol Y, Bal N, Alwis I, Nedoboy PE, Farnham MMJ, White MD, Cistulli PA, Cook KM.(3582T, 1:1000, Cell Signaling Technologies), JMJD2A (5328, 1:1000, Cell Signaling Technologies), JMJD2B (8639, 1:1000, Cell Signaling Technologies), JMJD2C (ab226480, 1:500, Abcam). Quantitative RT-PCR Total

(8) Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidineMolecular cellAugust 4, 2022Arango D, Sturgill D, Yang R, Kanai T, Bauer P, Roy J, Wang Z, Hosogane M, Schiffers S, Oberdoerffer S.(1:2000 dilution, Cat. #: ab191032, Abcam), rabbit anti-KDM4B (1:2000 dilution, clone D7E6, Cat. #: 8639S, Cell Signaling Technologies), rabbit anti-PXN (1:2000 dilution, Cat. #: 10029-1-Ig, ProteinTech), rabbit

(9) KDM4B Overexpression Promotes the Growth, Migration, and Invasion of Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Activating STAT3 PathwayBiochemical GeneticsDecember 1, 2021Xin Zhang, He Nan, Jialong Guo, Jinyu Liusolution and quantified by ImageJ software. Primary antibodies were listed as follows: KDM4B (Cat no. #8639, dilution 1/1000), β-actin (Cat no. #4970, dilution 1/1000, Cell Signaling Technology), p-STAT3 (Cat

(10) VLX600 Disrupts Homologous Recombination and Synergizes with PARP Inhibitors and Cisplatin by Inhibiting Histone Lysine DemethylasesMolecular cancer therapeuticsSeptember 1, 2021Ekstrom TL, Pathoulas NM, Huehls AM, Kanakkanthara A, Karnitz LM.(1:1,000; Catalog No. 5328, Cell Signaling Technology), rabbit monoclonal KDM4B (1:1,000; Catalog No. 8639, Cell Signaling Technology), rabbit polyclonal KDM4C (1:1,000; Catalog No. A300–885A, Bethyl Laboratories),

(11) Epigenetic modulation reveals differentiation state specificity of oncogene addictionNature communicationsMarch 9, 2021Khaliq M, Manikkam M, Martinez ED, Fallahi-Sichani M.Cell Signaling Technology, Cat# 5328, AB_10828595, 1:100), Kdm4b (rabbit mAb, clone D7E6, Cell Signaling Technology, Cat# 8639, AB_11140642, 1:100), Kdm5a (rabbit mAb, clone EPR18651, Abcam, Cat# ab194286, AB_2889152, 1:1600),

(12) MicroRNA-15a Carried by Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibits the Immune Evasion of Colorectal Cancer Cells by Regulating the KDM4B/HOXC4/PD-L1 AxisFrontiers in cell and developmental biologyJanuary 1, 2021Liu L, Yu T, Jin Y, Mai W, Zhou J, Zhao C.Cell Signaling Technologies, Beverly, MA, United States), PD-L1 (1:5000, #13684, Cell Signaling Technologies), KDM4B (1:2000, #8639, Cell Signaling Technologies), HOXC4 (1:2000, #55962, Cell Signaling Technologies), GAPDH (1:10,000,

(13) Long non-coding RNA steroid receptor activator promotes the progression of endometrial cancer via Wnt/ Î²-catenin signaling pathwayInternational Journal of Biological SciencesJanuary 1, 2020Sun-Ae Park, Lee Kyung Kim, Young Tae Kim, Tae-Hwe Heo, Hee Jung Kimfactor eIF4E contributes to its transformation and mRNA transport activities. Cancer research. 2004; 64: 8639-42. Castellvi J, Garcia A, Ruiz-Marcellan C, Hernández-Losa J, Peg V, Salcedo M, et al. Cell signaling

(14) Epigenetic Regulation of a Disintegrin and Metalloproteinase (ADAM) Transcription in Colorectal Cancer Cells: Involvement of β-Catenin, BRG1, and KDM4Frontiers in cell and developmental biologyJanuary 1, 2020Sun L, Chen B, Wu J, Jiang C, Fan Z, Feng Y, Xu Y.(Cell Signaling Tech, 8480), anti-KDM4A (Cell Signaling Tech, 5328), anti-KDM4B (Cell Signaling Tech, 8639), anti-KDM4C (Bethyl Laboratories, A300-885A), and anti–β-actin (Sigma, A2228) antibodies. All experiments

(15) Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivationNucleic acids researchDecember 16, 2019Duan L, Chen Z, Lu J, Liang Y, Wang M, Roggero CM, Zhang QJ, Gao J, Fang Y, Cao J, et al.and proximity ligation assays Antibodies against following proteins were used in this study: KDM4B (#8639), pCREB(#9198), HA (#3724), and hnRNAPA1 (#8443) (Cell Signaling); H3K9me3 (ab8898, Abcam); AR (PG21,

(16) RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia responseWellcome open researchJanuary 1, 2019Frost J, Ciulli A, Rocha S.Cell Signalling; monoclonal; rabbit; 1:2000), JMJD1A (ABE195, Millipore; polyclonal; rabbit; 1:1000), JMJD2B (8639S, Cell Signalling; monoclonal; rabbit; 1:1000), JMJD2C (PA5-23065, Thermo Scientific; polyclonal; rabbit;

(17) KDM4B-regulated unfolded protein response as a therapeutic vulnerability in PTEN-deficient breast cancerThe Journal of experimental medicineNovember 5, 2018Wang W, Oguz G, Lee PL, Bao Y, Wang P, Terp MG, Ditzel HJ, Yu Q.following SDS-PAGE using standard methods. Antibodies used for immunoblotting were KDM4B (Cell Signaling; #8639, 1:1,000 dilution), cleaved PARP (Cell Signaling; #9541, 1:1,000 dilution), ATF4 (Cell Signaling; #11815,

(18) Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recoveryNature communicationsSeptember 28, 2018Hsieh HJ, Zhang W, Lin SH, Yang WH, Wang JZ, Shen J, Zhang Y, Lu Y, Wang H, Yu J, et al.protein G agarose beads for 1 h. The antibodies we used for ChIP-quantitative PCR were rabbit anti-KDM4B (8639S; Cell Signaling Technology), ChIP-grade rabbit anti-H3-trimethyl K9 (H3K9me3; ab8898; Abcam), rabbit

(19) KDM4B histone demethylase and G9a regulate expression of vascular adhesion proteins in cerebral microvesselsScientific ReportsJuly 1, 2017Ji-Young Choi, Sang-Sun Yoon, Sang-Eun Kim, Sangmee Ahn Jopolyclonal,Millipore,07–442 Anti-G9a,Rabbit monoclonal,Cell signaling,3306 Anti-KDM4B,Rabbit monoclonal,Cell signaling,8639 List of antibodies for ChIP assay.

(20) KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damageNucleic acids researchApril 20, 2017Castellini L, Moon EJ, Razorenova OV, Krieg AJ, von Eyben R, Giaccia AJ.(Bio-Rad Laboratories). The following primary antibodies were used to detect specific proteins: JMJD2B (#2898 and #8639, Cell Signaling), p53 (DO-1, Santa Cruz Biotechnology), phospho-p53 S15 (Cell Signaling), p21 (Santa

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JMJD2B (D7E6) Rabbit mAb

JMJD2B (D7E6) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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JMJD2B (D7E6) Rabbit mAb from Cell Signaling Technology

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