The Copper Transporting ATPase 2 Antibody: RPE from AAA Biotech, LLC is a Mouse Monoclonal antibody to ATP7B. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The Copper Transporting ATPase 2 Antibody: RPE has been shown to work in the following applications: Precipitation, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Background Info: Detects ~160kDa in rat brain membrane preparations
Scientific Background: The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7b is an important protein for copper transport and elimination of excess copper from the body. ATP7b transports metals in and out of cells using ATP. There are 3 known isoforms of the ATP7b gene; A is found in the liver, kidney, and brain, the shorter form B is found in brain tissue, and the third isoform, known as WND/140 KDA is found in mitochondria. Mutations in the ATP7b gene can cause Wilson's disease, an inherited disorder causing copper poisoning in the brain and liver, characterized by neurological symptoms and hepatic damage