The ATP7B Antibody from AAA Biotech, LLC is a Rabbit Polyclonal antibody to ATP7B. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The ATP7B Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, Immunohistochemistry, and Western Blot.
Description
Description: This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).
Function: Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
Subunit Structure: Monomer. Interacts with COMMD1/MURR1 (PubMed:12968035, PubMed:17919502). Interacts with DCTN4, in a copper-dependent manner (PubMed:16554302). Interacts with ATOX1 (PubMed:18558714). Interacts (via C-terminus) with ZBTB16/PLZF (PubMed:16676348).
Post-translational Modifications: Isoform 1 may be proteolytically cleaved at the N-terminus to produce the WND/140 kDa form.
Similarity: Each HMA domain can bind a copper ion, they are tightly packed and closely interact with each other. Wild-type ATP7B can usually be loaded with an average 5.5 copper atoms per molecule. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily