The ATP7B Antibody from AAA Biotech, LLC is a Rabbit Polyclonal antibody to ATP7B. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The ATP7B Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, Immunocytochemistry, Immunofluorescence, and Immunohistochemistry.
Description
Function: Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
Subunit Structure: Monomer. Interacts with COMMD1/MURR1 (PubMed:12968035, PubMed:17919502). Interacts with DCTN4, in a copper-dependent manner (PubMed:16554302). Interacts with ATOX1 (PubMed:18558714). Interacts (via C-terminus) with ZBTB16/PLZF (PubMed:16676348).
Post-translational Modifications: Isoform 1 may be proteolytically cleaved at the N-terminus to produce the WND/140 kDa form.
Similarity: Each HMA domain can bind a copper ion, they are tightly packed and closely interact with each other. Wild-type ATP7B can usually be loaded with an average 5.5 copper atoms per molecule. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily