Anti-RIL/PDLIM4 Antibody, Rabbit Polyclonal from AAA Biotech, LLC

PDZ/LIM genes encode a group of proteins that play very important, but diverse, biological roles. Several recently identified PDZ-LIM proteins have been suggested to participate in many fundamental biological processes such as cytoskeleton organization, neuronal signaling, cell-lineage specification, and organ development as well as pathological processes like oncogenesis. Ten genes have been reported that encode for a PDZ domain and one or several LIM domains: four genes of the ALP subfamily (ALP, Elfin, Mystique, and PDLIM4), three of the Enigma subfamily (Enigma, Enigma Homolog, and ZASP), the two LIM kinases (LIMK1 and LIMK2), and the LIM only protein 7 (LMO7). Functionally, all PDZ and LIM-domain proteins share an important trait, i.e., they can associate with and/or influence the actin cytoskeleton. PDZ-LIM proteins act as adapters recruiting signaling molecules to the actin cytoskeleton. They associate with the actin cytoskeleton via their PDZ domains, and with kinases via their LIM domains. The LIM-domain proteins have been found to be expressed in prostatic epithelial cells as well as cancerous cells including ARA55/Hic5, FHL2, PCD1, TES, and PINCH. LIM-domain genes that have been proposed to be tumor suppressors include TES, LIMD1, Limatin, and EPLIN. Both TES and EPLIN were shown to be associated with actin and capable of suppressing cell motility or anchorage independent growth of transformed cells. The PDLIM4 LIM domain can interact with PDZ domains in the protein tyrosine phosphatase PTP-BL, and with the PDZ domain of PDLIM4 itself. Besides, the PDZ domain of PDLIM4 was shown to interact with the second LIM domain, TRIP6, a protein containing three C-terminal LIM domains