Anti-SNPH Antibody, Rabbit Polyclonal from AAA Biotech, LLC

Syntaphilin (SNPH) inhibits the movement of mitochondria in tumor cells, preventing their accumulation at the cortical cytoskeleton and limiting the bioenergetics of cell motility and invasion. Syntaphilin (SNPH) is a major mitochondrial anchoring protein targeted to axons and excluded from dendrites. SNPH may function as a unique, ubiquitination-regulated suppressor of metastasis. SNPH associates with multiple regulators of ubiquitin-dependent responses and is ubiquitinated by the E3 ligase CHIP (or STUB1) on Lys111 and Lys153 in the microtubule-binding domain. SNPH ubiquitination did not result in protein degradation, but instead anchored SNPH on tubulin to inhibit mitochondrial motility and cycles of organelle fusion and fission, that is dynamics. Although considered neuronal-specific, SNPH is, in fact, broadly expressed in cancer, suppresses mitochondrial trafficking to the cortical cytoskeleton, and restricts tumor cell movements and metastasis, in vivo. In addition, SNPH is progressively downregulated or lost during tumor progression, correlating with worse disease outcome