The Anti-RBL1 Antibody, Rabbit Polyclonal from AAA Biotech, LLC is a Rabbit Polyclonal antibody. This antibody recognizes Homo Sapiens, and Human antigen. The Anti-RBL1 Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
RBL1 (RB Transcriptional Corepressor Like 1) is a Protein Coding gene. The RBL1 gene, located on 20q11.23, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, A.thaliana, rice, and frog. The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. Also, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. RB1 is widely expressed in the lymph node, bone marrow, and other tissues. Diseases associated with RBL1 include Retinoblastoma and Bilateral Retinoblastoma