AAA Biotech, LLC's Anti-ASTL Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry.
Description
SAS1B (sperm acrosomal SLLP1 binding protein; aka ovastacin, ASTL, GenBank ID NM_001002036.3) is an oocyte membrane-associated zinc metalloprotease binding partner for a sperm ligand which contributes to fertilization and also plays a role in the block to polyspermy. SAS1B, a 46 kDa protein, is comprised of a signal peptide at the N-terminus, pro-peptide, proteinase domain containing a Hex-box catalytic site, and a unique C-terminal domain. Among normal tissues, SAS1B expression is limited to the ovary, specifically to oocytes at or beyond the secondary follicle stage, and is absent in the quiescent ovarian reserve. In addition to localization within the ovary, SAS1B has also been shown to be expressed in a majority uterine tumors (66-85%). SAS1B represents one of the first defined antigens in a new class of cancer-oocyte antigens