AAA Biotech, LLC's Anti-Dppa2 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunofluorescence, and Immunohistochemistry. The Anti-Dppa2 Antibody, Rabbit Polyclonal was generated using DPPA2 as the antigen and it reacts with Homo Sapiens, and Human.
Description
The assembly of the spherical nucleus depends on a critical balance of microtubule dynamics, which is regulated by the chromatin-binding protein Developmental pluripotency-associated 2 (Dppa2). Whereas microtubules normally promote sperm pronuclear expansion, in Dppa2-depleted Xenopus egg extracts excess microtubules cause pronuclear assembly defects, leading to abnormal morphology and disorganized DNA replication. Dppa2 inhibits microtubule polymerization in vitro, and Dppa2 activity is needed at a precise time and location during nascent pronuclear formation. The developmental pluripotency-associated 2 (Dppa2), which regulates chromatin structures, plays important roles in the maintenance of pluripotency and proliferation of embryonic stem cells