The Anti-LRRC8B Antibody, Rabbit Polyclonal from AAA Biotech, LLC is a Rabbit Polyclonal antibody to LRRC8B. This antibody recognizes Homo Sapiens, and Human antigen. The Anti-LRRC8B Antibody, Rabbit Polyclonal has been shown to work in the following applications: Precipitation, Immunoprecipitation, and Western Blot.
Description
Leucine-rich repeat-containing 8 (LRRC8) proteins are evolutionarily originated from the combination of the channel protein pannexin, and a leucine-rich repeat (LRR) domain. Five paralogs of LRRC8, namely LRRC8A, LRRC8B, LRRC8C, LRRC8D and LRRC8E have been reported. LRRC8A has been shown to be instrumental in cell swelling. LRRC8B is a key player in the cellular Ca2+ signaling network. LRRC8B participates in intracellular Ca2+ homeostasis by acting as a leak channel in the endoplasmic reticulum (ER)