AAA Biotech, LLC's Anti-UPF3B/RENT3B Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
Mutation in the UPF3B gene on chromosome X is implicated in neurodevelopmental disorders including intellectual disability (ID) and is strongly associated with autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and schizophrenia (SCZ). The protein UPF3B is involved in the nonsense-mediated mRNA decay pathway (NMD) that controls mRNA stability and functions in the prevention of the synthesis of truncated proteins. UPF3B is a core member of the NMD pathway that functions to rapidly degrade transcripts with premature termination codons (PTCs). In mammals, Up-frameshift proteins (UPFs) form a surveillance complex that interacts with the exon junction complex (EJC) to elicit NMD. UPF3b is the component of the surveillance complex that bridges the interaction with the exon junction complex (EJC)