Description
Product Characteristics: Name/Gene ID: RASA3
Synonyms: RASA3, GAPIII, GAP1(IP4BP), GTPase activating protein III, Ins(1,3,4,5)P4-binding protein, GAP1IP4BP, Ins P4-binding protein, RAS p21 protein activator 3
Target Information: The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane. [provided by RefSeq, Jul 2008]