TSHR (3B12) Antibody sc-53542 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemTSHR (3B12) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-53542
NCBI Gene AliasesLGR3, pet, hyt, hypothroid, hTSHR-I, CHNG1
Antibody TypePrimary Antibodies
Clone3B12
Quantity200 µg/ml
ApplicationsWB, IP, IF, IHC(P), FCM
Reactivitymouse, rat, human, bovine, porcine, feline, canine
Conjugate/TagUnconjugated
Hostmouse
FormatPurified
ClonalityMonoclonal
NCBI Full Gene Namethyroid stimulating hormone receptor
TargetTSHR
IsotypeIgG1

Questions and Answers

What species can I use this TSHR antibody on for my experiments?

The TSHR (3B12) antibody is reactive with multiple species, including humans, mice, rats, bovines, canines, felines, and porcine. This broad reactivity allows for its application in various animal models.

Has this antibody been used in any specific research studies?

Yes, the TSHR (3B12) antibody has been cited in several scientific articles. For instance, it was utilized in a study investigating the role of fibrocytes in Graves' disease, where it helped demonstrate the expression of TSHR in human CD34+ fibrocytes and their response to TSH, highlighting its relevance in thyroid-associated ophthalmopathy ().

Can this antibody be used for immunohistochemistry applications?

The TSHR (3B12) antibody has been shown to work in immunohistochemistry applications, as indicated by its use in studies examining thyroid function and pathology, including the expression of TSHR in various cell types within the thyroid gland ().

What is the significance of using a monoclonal antibody like this one in my research?

Monoclonal antibodies, such as the TSHR (3B12) antibody, provide high specificity and consistency in binding to their target antigen. This is particularly important in studies where precise detection of TSHR expression is crucial, such as in understanding thyroid dysfunctions and autoimmune conditions.

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Uptake in thyroid Tripterygium glycosides, enhances radioiodine cancer by promoting the expression and function of NISScientific ReportsApril 28, 2026Zhangguo Ying, Wangang Gong, Mengmeng Shi, Yujie Chen, Yalan Daimethodologies25. Antibodies: Sodium iodide symporter antibody (24324-1-AP, Santa Cruz). TSHR antibody (sc-53542, Cell Signaling Technology), Detection System: UltraSensitive™ SP (Mouse/Rabbit) IHC Kit (Cat# KIT-9710,

(2) Expression, immunogenicity and clinical significance analysis of thyroid‑stimulating hormone receptor fusion proteinsMolecular Medicine ReportsJuly 29, 2025Xia Chen, Hui Chenh. The PVDF membrane was then blocked and incubated with antibodies, including TSHR 3B12 (1:1,000; sc-53542; Santa Cruz Biotechnology, Inc.; 4°C; 12 h) and His (1:1,000; 1B7G5; Proteintech Group, Inc.; 4°C; 12

(3) Monoclonal Antibodies to Thyrotropin Receptor With Thyroid-Stimulating Activity Activate the NF-κB Pathway to Induce Chemokine ExpressionJ Cell Mol MedJune 11, 2025Yang Yang, Chen HuiHypoxanthine and Thymidine (HT) Supplement (50×) (11067030, Thermo Fisher Scientific), TSHR antibody (3B12, sc‐53542, Santa Cruz Biotechnology Inc., Dallas, USA) for western blot, rabbit anti‐mouse IgG‐horseradish peroxidase

(4) Orally Administered 6:2 Chlorinated Polyfluorinated Ether Sulfonate (F-53B) Causes Thyroid Dysfunction in RatsToxicsAugust 8, 2020Hong SH, Lee SH, Yang JY, Lee JH, Jung KK, Seok JH, Kim SH, Nam KT, Jeong J, Lee JK, et al.vehicle control and treatment groups [21]. Antibodies for thyroid-stimulating hormone receptor (TSHR; sc-53542) 2.1. Testand Substance thyroperoxidase (TPO; sc-58432) were obtained from Santa Cruz Biotechnology

(5) Papillary Thyroid Cancer Tumor Spheres Cultured by Passaging Without Sorting Exhibit Cancer StemnessAnticancer researchJuly 1, 2020Cho JM, Lee HJ, Chung JH, Kim WY, Kang MH, Ha KS, Woo SU, Lee JB.

(6) Di-2-ethylhexylphthalate promotes thyroid cell proliferation and DNA damage through activating thyrotropin-receptor-mediated pathways in vitro and in vivoFood and chemical toxicology : an international journal published for the British Industrial Biological Research AssociationFebruary 1, 2019Kim S, Park GY, Yoo YJ, Jeong JS, Nam KT, Jee SH, Lim KM, Lee YS.

(7) Slit2 Modulates the Inflammatory Phenotype of Orbit-Infiltrating Fibrocytes in Graves' DiseaseJournal of immunology (Baltimore, Md. : 1950)June 15, 2018Fernando R, Grisolia ABD, Lu Y, Atkins S, Smith TJ.from Life Technologies. Anti-TSHR Ab (3B12) was from Santa Cruz Biotechnology (Dallas, TX) (cat. no. sc-53542). Isotype-matched Downloaded from http://www.jimmunol.org/ by guest on November 16, 2021 FIGURE 1.

(8) In silico and in vitro analysis of cross-reactivity between Yersinia pseudotuberculosis OmpF porin and thyroid-stimulating hormone receptorInternational journal of biological macromoleculesFebruary 1, 2018Portnyagina O, Zelepuga E, Khomenko V, Solov'eva E, Solov'eva T, Novikova O.

(9) Elevated Serum Tetrac in Graves Disease: Potential Pathogenic Role in Thyroid-Associated OphthalmopathyThe Journal of clinical endocrinology and metabolismMarch 1, 2017Fernando R, Placzek E, Reese EA, Placzek AT, Schwartz S, Trierweiler A, Niziol LM, Raychaudhuri N, Atkins S, Scanlan TS, et al.

(10) Hypoxia promotes thyroid differentiation of native murine induced pluripotent stem cellsThe International journal of developmental biologyJanuary 1, 2016Yang Y, Lu Y, Chen T, Zhang S, Chu B, Gong Y, Zhao W, Zhu J, Liu Y.antibody (sc-134515, Santa Cruz Biotechnology, CA, 1:50), monoclonal mouse anti-TSH receptor antibody (sc-53542, Santa Cruz Biotechnology, CA, 1:50), monoclonal rabbit anti-Foxa2 antibody (ab108422, Abcam, 1:350),

(11) CD40 Expression in Fibrocytes Is Induced by TSH: Potential Synergistic Immune ActivationPloS oneJanuary 1, 2016Mester T, Raychaudhuri N, Gillespie EF, Chen H, Smith TJ, Douglas RS.

(12) Teprotumumab, an IGF-1R blocking monoclonal antibody inhibits TSH and IGF-1 action in fibrocytesThe Journal of clinical endocrinology and metabolismSeptember 1, 2014Chen H, Mester T, Raychaudhuri N, Kauh CY, Gupta S, Smith TJ, Douglas RS.

(13) Expression of thyrotropin receptor, thyroglobulin, sodium-iodide symporter, and thyroperoxidase by fibrocytes depends on AIREThe Journal of clinical endocrinology and metabolismJuly 1, 2014Fernando R, Lu Y, Atkins SJ, Mester T, Branham K, Smith TJ.

(14) Communication between the calcium and cAMP pathways regulate the expression of the TSH receptor: TRPC2 in the center of actionMolecular endocrinology (Baltimore, Md.)December 1, 2012Löf C, Sukumaran P, Viitanen T, Vainio M, Kemppainen K, Pulli I, Näsman J, Kukkonen JP, Törnquist K.

(15) Proangiogenic effect of TSH in human microvascular endothelial cells through its membrane receptorThe Journal of clinical endocrinology and metabolismMay 1, 2012Balzan S, Del Carratore R, Nicolini G, Beffy P, Lubrano V, Forini F, Iervasi G.

(16) Thyroid redox imbalance in adult Wistar rats that were exposed to nicotine during breastfeedingScientific reportsJanuary 1, 0001"Miranda RA, de Moura EG, Soares PN, Peixoto TC, Lopes BP, de Andrade CBV, de Oliveira E, Manhães AC, de Faria CC, Fortunato RS, et al."/Santa Cruz Biotechnology MA, USA 1:500 AP106B/Millipore Corporation CA, USA 1:10,000 Anti-goat TSHr sc-53542/Santa Cruz Biotechnology MA, USA 1:500 B8520/Sigma-Aldrich MO, USA 1:10,000 Anti-mouse Cyclophilin #51418/Cell Signaling Technology

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TSHR (3B12) Antibody

TSHR (3B12) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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TSHR (3B12) Antibody from Santa Cruz Biotechnology, Inc.

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