IGF-IR (3B7) Antibody sc-462 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemIGF-IR (3B7) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-462
Antibody TypePrimary Antibodies
NCBI Gene AliasesIGFR, D930020L01, IGFIR, A330103N21Rik, CD221, IGF-1R, JTK13, hyft
ApplicationsIP, FCM
Reactivitymouse, rat, human
Clone3B7
Quantity200 µg/ml
ClonalityMonoclonal
FormatPurified
Conjugate/TagUnconjugated
Hostmouse
NCBI Full Gene Nameinsulin like growth factor 1 receptor, insulin-like growth factor I receptor
TargetIGF-IR
IsotypeIgG1

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Synergistic effects through targeting the PI3K and IGFR pathways in treating lung cancer carrying activation alterations along the PI3K pathwayTransl OncolApril 3, 2026Mohamed Abd El-Salam, Wu Chen, Yan Tang, Ting Rao, Xuejia Kang, Lifang Sun, Tiegang Han, Pengyu Chen, Matthew Mossanen, Fan Cheng, et al.anti-caspase-3 (Abcam Cat# ab32351; RRID: AB_725946), mouse anti-IGF-1R (Santa Cruz Biotechnology Cat# sc-462; RRID: AB_627781), HRP-conjugated secondary antibodies (Bio-Rad, Cat #: 12010020). In vitro experiments

(2) Role of the Insulin Receptor in Mediating Cytosolic Delivery of Proteins by a Modified Cell-Penetrating PeptidePharmaceuticals (Basel)December 12, 2025Keito Sugai, Akiko OkudaBlocking One at room temperature; incubated overnight at 4 °C with primary antibodies against IGF1R (3B7, sc-462; Santa Cruz Biotechnology) or INSR (CT3, sc-57342; Santa Cruz Biotechnology) diluted 1:200 in Immuno

(3) Inhibiting SCD expression by IGF1R during lorlatinib therapy sensitizes melanoma to ferroptosisRedox BiologyMay 1, 2023Furong Zeng, Lin Ye, Qian Zhou, Yi He, Yilei Zhang, Guangtong Deng, Xiang Chen, Hong Liu(Santa Cruz, sc-271126), FRK (Santa Cruz, sc-166478), EGFR (Santa Cruz, sc-373746), IGF1R (Santa Cruz, sc-462), TSSK2 (Santa Cruz, sc-100437), JAK2 (Santa Cruz, sc-390539), EPHA1 (Santa Cruz, sc-65993). 4.5 Cell

(4) Macrophage-derived IGF-1 protects the neonatal intestine against necrotizing enterocolitis by promoting microvascular developmentCommunications biologyApril 6, 2022Yan X, Managlia E, Zhao YY, Tan XD, De Plaen IG.was purchased from BD Biosciences (Franklin Lakes, NJ). Anti-IGF-1 Ab (sc-518040), anti-IGF-1R Ab (sc-462) and their isotype controls (for FACS), anti-VEGF-A Ab (sc-7269), and anti-IGF-1Rα Ab (sc-463) for western blotting

(5) Insuline-Like Growth Factor-2 (IGF2) and Hepatocyte Growth Factor (HGF) Promote Lymphomagenesis in p53-null Mice in Tissue-specific and Estrogen-signaling Dependent MannersJournal of CancerJanuary 1, 2021Huang HS, Chu SC, Chen PC, Lee MH, Huang CY, Chou HM, Chu TY.(sc-20047, Santa Cruz), pan-cytokeratin (1:100 dilution) (sc-15367, Santa Cruz), IGF1R (1:200 dilution) (sc-462, Santa Cruz), cMET (1:200 dilution) (bs-0668R, BIOSS), and ERα (1:200 dilution) (#8644, Cell Signaling). Data

(6) IGF-axis confers transformation and regeneration of fallopian tube fimbria epithelium upon ovulationEBioMedicineMarch 1, 2019Hsu CF, Huang HS, Chen PC, Ding DC, Chu TY.(2797–1, Epitomics), anti-NANOG (GTX100863, Genetex), anti-OCT4 (MAB4305, Millipore), anti-IGF-1R (sc-462, Santa Cruz), and anti-CD3 (sc-20047, Santa Cruz). Next, the sections were incubated with the appropriate

(7) Suppression of IGF1R in Melanoma Cells by an Adenovirus-Mediated One-Step Knockdown SystemMolecular therapy. Nucleic acidsSeptember 7, 2018Xin H, Lei M, Zhang Z, Li J, Zhang H, Luo X, Wang A, Deng F.(NP-40) for 5 min, and blocked with 10% BSA. Then, the cells were incubated with antibody against IGF1R (sc-462, Santa Cruz Biotechnology) or cleaved caspase-3 (9661, Cell Signaling Technology) at 4°C for overnight.

(8) MicroRNA‑539 inhibits cell proliferation, colony formation and invasion in pancreatic ductal adenocarcinoma by directly targeting IGF‑1RMolecular medicine reportsAugust 1, 2018Lin Y, Rong L, Zhao J, Lin R, Li S.antibodies used in this study include mouse anti‑human IGF‑1R monoclonal antibody (1:1,000 dilution; cat no. sc‑462; Santa Cruz Biotechnology, Inc., Dallas, TX, USA) and mouse anti‑human GAPDH monoclonal antibody (1:1,000 dilution;

(9) Estradiol-ERβ2 signaling axis confers growth and migration of CRPC cells through TMPRSS2-ETV5 gene fusionOncotargetSeptember 8, 2017Kim H, Datta A, Talwar S, Saleem SN, Mondal D, Abdel-Mageed AB.anti-c-Src (32G6) mAb (#2011; Cell Signaling Technology Inc.; Danvers, MA), or mouse anti-IGF-1R mAb (#sc-462; Santa Cruz Biotechnology, Inc.). Immune complexes were pulled down by protein A/G magnetic beads (0.25

(10) The Progestin Receptor Interactome in the Female Mouse Hypothalamus: Interactions with Synaptic Proteins Are Isoform Specific and Ligand DependenteNeuroSeptember 1, 2017Acharya KD, Nettles SA, Sellers KJ, Im DD, Harling M, Pattanayak C, Vardar-Ulu D, Lichti CF, Huang S, Edwards DP, et al.,BD Biosciences,611806,Mouse AR-441_M_V,BCM,NW-Mab70,Mouse AMPKa(F6)_M_V,CST,2793,Mouse Bcl2(Clone-124)_M_V,Dako,M088729-2,Mouse c-Src(B-12)_M_V,Santa Cruz Biotechnology,sc-8056,Mouse IGF-IR(3B7)_M_V,Santa Cruz Biotechnology,sc-462,Mouse Laminin5_M_V,EMD Millipore,MAB19562,Mouse Aromatase-A(Clone 677H7F10)_M_V,BCM-Mab,in house,Mouse AOX1(cloneAO15)_M_V,Sigma-Aldrich,SAB4200562,Mouse IDH2_M_V,Abcam,ab55271,Mouse SCD1

(11) Disrupted TSH Receptor Expression in Female Mouse Lung Fibroblasts Alters Subcellular IGF-1 Receptor DistributionEndocrinologyDecember 1, 2015Atkins SJ, Lentz SI, Fernando R, Smith TJ.

(12) microRNA-99a is downregulated and promotes proliferation, migration and invasion in non-small cell lung cancer A549 and H1299 cellsOncology lettersMarch 1, 2015Chen C, Zhao Z, Liu Y, Mu D.(sc-7939, rabbit, IgG), γ-catenin (sc-30997, goat, IgG), insulin-like growth factor 1 receptor (IGF-1R; sc-sc462, mouse, IgG1) or β-actin (sc-1616, goat, IgG) (Santa Cruz Biotechnology, Dallas, TX, USA). The antibodies

(13) A molecular model for the mechanism of acquired tamoxifen resistance in breast cancerEur J CancerNovember 1, 2014Fan P, Agboke FA, Cunliffe HE, Ramos P, Jordan VC.(San Diego, CA). Sources of antibodies for Western blot were as follows: ERα (sc-544), mouse IGF-1Rβ (sc-462), and rabbit IGF-1Rβ (sc-713) antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA). Total

(14) Effects of the masticatory demand on the rat mandibular developmentJournal of oral rehabilitationAugust 1, 2014Hichijo N, Kawai N, Mori H, Sano R, Ohnuki Y, Okumura S, Langenbach GE, Tanaka E.

(15) Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptorPloS oneJanuary 1, 2014Li J, Kang Y, Wei L, Liu W, Tian Y, Chen B, Lin X, Li Y, Feng GS, Lu Z.levels were determined by Western blot analysis. The antibodies to ERα (mc20, SC-542), IGF-1R (3B4, SC-462), Cyclin D1 (sc-753), Akt1 (B-1, SC-5298), p-Akt (Ser 473) (SC-798512), Erk (C-16, SC-16982), p-Erk

(16) Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasisPloS oneJanuary 1, 2013Saldana SM, Lee HH, Lowery FJ, Khotskaya YB, Xia W, Zhang C, Chang SS, Chou CK, Steeg PS, Yu D, et al.AlexaFluor 647 mouse anti-IGF-1 Receptor (pY1131; #558588, BD Biosciences) or anti-IGF-IR-PE (3B7; #sc-462, Santa Cruz Biotechnology) and analyzed using the BC Gallios flow cytometer. Unstained cells were used

(17) Inhibition of hepatocellular carcinoma cell growth by an anti-insulin-like growth factor-I receptor monoclonal antibodyOncology reportsOctober 1, 2012Yue L, Wang Y, Wang H, Gao H, Liang J, Sui A, Xiang J, Zhou F, Xu C, Zhao W, et al.

(18) Green tea (-)-epigallocatechin gallate inhibits IGF-I and IGF-II stimulation of 3T3-L1 preadipocyte mitogenesis via the 67-kDa laminin receptor, but not AMP-activated protein kinase pathwayMolecular nutrition & food researchApril 1, 2012Ku HC, Liu HS, Hung PF, Chen CL, Liu HC, Chang HH, Tsuei YW, Shih LJ, Lin CL, Lin CM, et al.

(19) Evaluation of a novel hexavalent humanized anti-IGF-1R antibody and its bivalent parental IgG in diverse cancer cell linesPloS oneJanuary 1, 2012Chang CH, Wang Y, Trisal P, Li R, Rossi DL, Nair A, Gupta P, Losman M, Cardillo TM, Rossi EA, et al.

(20) Amphioxus IGF-like peptide induces mouse muscle cell development via binding to IGF receptors and activating MAPK and PI3K/Akt signaling pathwaysMolecular and cellular endocrinologyAugust 22, 2011Liu M, Zhang S.

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IGF-IR (3B7) Antibody

IGF-IR (3B7) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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IGF-IR (3B7) Antibody from Santa Cruz Biotechnology, Inc.

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