Bioss Inc.'s EGFR (Tyr1068) Polyclonal Antibody, RBITC Conjugated is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunofluorescence. The EGFR (Tyr1068) Polyclonal Antibody, RBITC Conjugated was generated using EGFR, and epidermal growth factor receptor as the antigen and it reacts with Homo Sapiens, Human, Mouse, and Rat.
Description
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma