The Sclerostin Polyclonal Antibody, PE-Cy7 Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to sclerostin, and SOST. This antibody recognizes Homo Sapiens, Human, Mouse, Rat, Canine, and Porcine antigen. The Sclerostin Polyclonal Antibody, PE-Cy7 Conjugated has been shown to work in the following applications: Western Blot.
Description
Negative regulator of bone growth.Sclerostin (SOST) is a bone morphogenetic protein (BMP) antagonist, leading to the activation of BMP signaling. It negatively regulates the formation of bone by repressing the differentiation and/or function of osteoblasts induced by BMPs. It has been shown that Sclerostin binds BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity. The noggin-sclerostin protein complex represents a novel mechanism for the fine-tuning of BMP activity in bone homeostasis. Evidence is accumulating that one of the important mechanisms of bone regulation by sclerostin is the modulation of Wnt/Beta-catenin signaling. Sclerostin also rapidly activated ERK-1/2 MAPK signaling, indicating the involvement of additional signaling pathways