The AIM2 Polyclonal Antibody, PE-Cy7 Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to absent in melanoma 2, and AIM2. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The AIM2 Polyclonal Antibody, PE-Cy7 Conjugated has been shown to work in the following applications: Flow Cytometry, and Western Blot.
Description
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8