The TNF Receptor I Polyclonal Antibody, Cy3 Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to TNFRSF1A. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The TNF Receptor I Polyclonal Antibody, Cy3 Conjugated has been shown to work in the following applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase