The c-Ros Polyclonal Antibody, PE Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to ROS1. This antibody recognizes Homo Sapiens, Human, and Rat antigen. The c-Ros Polyclonal Antibody, PE Conjugated has been shown to work in the following applications: Flow Cytometry, and Western Blot.
Description
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2