Topo I (C-21) Antibody sc-32736 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemTopo I (C-21) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-32736
NCBI Gene AliasesTop-1, TOPI, D130064I21Rik
Antibody TypePrimary Antibodies
Quantity200 µg/ml
CloneC-21
Reactivitymouse, rat, human
ApplicationsWB, IP, IF, IHC(P)
FormatPurified
Conjugate/TagUnconjugated
Hostmouse
ClonalityMonoclonal
NCBI Full Gene NameDNA topoisomerase I, topoisomerase (DNA) I
TargetTopo I
IsotypeIgM

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Unraveling the Role of JMJD1B in Genome Stability and the Malignancy of MelanomasInternational Journal of Molecular SciencesOctober 4, 2024Perla Cruz, Diego Peña-Lopez, Diego Figueroa, Isidora Riobó, Vincenzo Benedetti, Francisco Saavedra, Claudia Espinoza-Arratia, Thelma M. Escobar, Alvaro Lladser, Alejandra LoyolaJMJD1B (Cell Signaling Technology, Danvers, MA, USA, 2621S), NASP (Abcam, ab181169), Topo I (Santa Cruz, sc-32736), anti-Mouse IgG HRP (Rockland, Philadelphia, PA, USA, 610-1302), anti-Rabbit IgG HRP (Rockland, 611-1322),

(2) RNA interacts with topoisomerase I to adjust DNA topologyMolecular CellSeptember 5, 2024Mannan Bhola, Kouki Abe, Paola Orozco, Homa Rahnamoun, Pedro Avila-Lopez, Elijah Taylor, Nefertiti Muhammad, Bei Liu, Prachi Patel, John F. Marko, et al.for immunoblotting are as follows: anti-beta-actin (Santa Cruz, sc47778, 1:1000 dilution), anti-TOP1 (Santa Cruz, sc-32736, 1:1000 dilution), anti-FLAG (Sigma, F3165, 1:1000 dilution), anti-Rpb1 NTD (D8L4Y) (Cell Signaling,

(3) Induction of the alternative lengthening of telomeres pathway by trapping of proteins on DNANucleic acids researchJuly 21, 2023Rose AM, Goncalves T, Cunniffe S, Geiller HEB, Kent T, Shepherd S, Ratnaweera M, O'Sullivan RJ, Gibbons RJ, Clynes D.(Santa Cruz, sc-365916, 1:200), rabbit anti-GAPDH (Cell Signaling, 2118, 1:1000), mouse anti-TOP1 (Santa Cruz, sc-32736, 1:500), mouse anti-pADPr (Santa Cruz, sc-56198, 1:100), mouse anti-PARP1 (Santa Cruz, sc-8007, 1:200),

(4) The Interactions of the 70 kDa Fragment of Cell Adhesion Molecule L1 with Topoisomerase 1, Peroxisome Proliferator-Activated Receptor γ and NADH Dehydrogenase (Ubiquinone) Flavoprotein 2 Are Involved in Gene Expression and Neuronal L1-Dependent FunctionsInternational journal of molecular sciencesJanuary 20, 2023Loers G, Kleene R, Bork U, Schachner M.

(5) Mechanism of action of non-camptothecin inhibitor Genz-644282 in topoisomerase I inhibitionCommunications biologySeptember 16, 2022Nishida M, Terabayashi T, Matsuoka S, Okuma T, Adachi S, Tomo T, Kawano M, Tanaka K, Tsumura H, Anai H, et al.Santa Cruz Biotechnology). TOP1 was analysed by western blotting using a mouse anti-Topo I antibody (C-21) (1:10,000, sc-32736; Santa Cruz Biotechnology). Commercial human MUS81 siRNA was used in this study (human MUS81 siRNA,

(6) Modulation of interleukin-36 based inflammatory feedback loop through the hepatocyte-derived IL-36R-P2X7R axis improves steatosis in alcoholic steatohepatitisBritish journal of pharmacologySeptember 1, 2022Shang Y, Yang HX, Li X, Zhang Y, Chen N, Jiang XL, Zhang ZH, Zuo RM, Wang H, Lan XQ, et al.

(7) Chaperone mediated autophagy contributes to the newly synthesized histones H3 and H4 quality controlNucleic acids researchFebruary 28, 2022Hormazabal J, Saavedra F, Espinoza-Arratia C, Martinez NW, Cruces T, Alfaro IE, Loyola A.ab25630), LAMP2A (ThermoFisher Scientific, 512200), LC3B (Cell Signaling, 2775), TopoI (Santa Cruz, sc32736), VDAC (Abcam, ab15895), Alexa 488 goat anti-mouse IgG (H + L) (ThermoFisher Scientific, A11001), anti-Mouse

(8) "MYC assembles and stimulates topoisomerases 1 and 2 in a ""topoisome"""Molecular cellJanuary 6, 2022Das SK, Kuzin V, Cameron DP, Sanford S, Jha RK, Nie Z, Rosello MT, Holewinski R, Andresson T, Wisniewski J, et al.ab109374; RRID: AB_10861978 Mouse monoclonal Anti-Topo I Antibody (C-21),Santa cruz Biotechnology,Cat# sc-32736; RRID: AB_628382 Rabbit monoclonal Anti-Topoisomerase II alpha antibody [EP1102Y],Abcam,Cat# ab52934;

(9) SENP1 participates in Irinotecan resistance in human colon cancer cellsJournal of cellular biochemistryOctober 1, 2021Chen MC, Nhan DC, Hsu CH, Wang TF, Li CC, Ho TJ, Mahalakshmi B, Chen MC, Yang LY, Huang CY.

(10) The benzylisoquinoline alkaloids, berberine and coptisine, act against camptothecin-resistant topoisomerase I mutantsScientific reportsApril 8, 2021Inoue N, Terabayashi T, Takiguchi-Kawashima Y, Fujinami D, Matsuoka S, Kawano M, Tanaka K, Tsumura H, Ishizaki T, Narahara H, et al.Santa Cruz Biotechnology). Topo I was analysed by western blotting using a mouse anti-Topo I antibody (C-21) (1:10,000, sc-32736, Santa Cruz Biotechnology). Commercial MUS81 siRNA was used in this study (human MUS81 siRNA, L-016143–01-0005,

(11) ZNF354C is a transcriptional repressor that inhibits endothelial angiogenic sproutingScientific reportsNovember 5, 2020Oo JA, Irmer B, Günther S, Warwick T, Pálfi K, Izquierdo Ponce J, Teichmann T, Pflüger-Müller B, Gilsbach R, Brandes RP, et al.Novus Biologicals, Cenntenial (USA)), Flag (#F3165-0.2MG, Sigma-Aldrich, Germany), Topoisomerase I (#sc-32736, Santa Cruz Biotechnology, Dallas (USA)) and HSC70/HSP70 (#ADI-SPA-820, Enzo Life Sciences, Lörrach,

(12) A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivoNeoplasia (New York, N.Y.)October 1, 2020Zhao L, Han X, Lu J, McEachern D, Wang S.Systems Biology, Novus Biologicals and Thermo Fisher Scientific, respectively. MAD1 (sc-47746), Topo1 (sc-32736), anti-rabbit IgG (sc-2357) and anti-mouse IgG (sc-516102) antibodies were purchased from Santa Cruz Biotechnology

(13) JMJD1B, a novel player in histone H3 and H4 processing to ensure genome stabilityEpigenetics & chromatinFebruary 18, 2020Saavedra F, Gurard-Levin ZA, Rojas-Villalobos C, Vassias I, Quatrini R, Almouzni G, Loyola A.(Abcam ab283887), JMJD1B (Cell Signaling Technology 2621S), NASP (Dr. Almouzni), Topo I (Santa Cruz sc-32736), SetDB1 (Abcam ab12317). Extract preparation HeLa cells were cultured in Dulbecco’s modified Eagle

(14) DNA topoisomerase 1 and 2A function as oncogenes in liver cancer and may be direct targets of nitidine chlorideInternational journal of oncologyNovember 1, 2018Liu LM, Xiong DD, Lin P, Yang H, Dang YW, Chen G.were used for the tissue microarrays. Mouse monoclonal anti-TOP1 antibody (1:50 dilution; catalog no. sc32736) and monoclonal anti-TOP2A antibody (1:50 dilution; catalog no. sc365916) (both from Santa Cruz Biotechnology, Inc

(15) The NORAD lncRNA assembles a topoisomerase complex critical for genome stabilityNatureSeptember 1, 2018Munschauer M, Nguyen CT, Sirokman K, Hartigan CR, Hogstrom L, Engreitz JM, Ulirsch JC, Fulco CP, Subramanian V, Chen J, et al.

(16) IRF4 haploinsufficiency in a family with Whipple's diseaseeLifeMarch 14, 2018Guérin A, Kerner G, Marr N, Markle JG, Fenollar F, Wong N, Boughorbel S, Avery DT, Ma CS, Bougarn S, et al.

(17) The convergent roles of NF-κB and ER stress in sunitinib-mediated expression of pro-tumorigenic cytokines and refractory phenotype in renal cell carcinomaCell death & diseaseMarch 7, 2018Makhov P, Naito S, Haifler M, Kutikov A, Boumber Y, Uzzo RG, Kolenko VM.ATF4 (#11815) were obtained from Cell Signaling Technology (Beverly, MA). ATF6 (sc-22799), Topo-1 (sc-32736), IκBα (sc-203), β-actin (sc-130300) and HA-probe (sc-7392) antibodies were obtained from Santa Cruz Biotechnology Inc

(18) C9orf72 expansion disrupts ATM-mediated chromosomal break repairNature neuroscienceSeptember 1, 2017Walker C, Herranz-Martin S, Karyka E, Liao C, Lewis K, Elsayed W, Lukashchuk V, Chiang SC, Ray S, Mulcahy PJ, et al.Covalent TOP1–DNA complexes were then detected by immunoblotting with anti-TOP1 polyclonal anti- bodies (sc-32736, Santa Cruz.) and visualised by chemiluminescence. Neutral single-cell agarose gel electrophoresis

(19) Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecanNucleic acids researchFebruary 17, 2017Meisenberg C, Ashour ME, El-Shafie L, Liao C, Hodgson A, Pilborough A, Khurram SA, Downs JA, Ward SE, El-Khamisy SF.overnight with 5% PBST-milk containing antibodies against TDP1 (ab4166; Abcam, Cambridge, UK), TOP1 (SC-32736; Santa Cruz Biotechnologies, California, USA), PARP1 and cleaved PARP1 (A6.4.12, Biorad, Hemel Hempstead,

(20) Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancerNature chemical biologyOctober 1, 2016Pollock JA, Wardell SE, Parent AA, Stagg DB, Ellison SJ, Alley HM, Chao CA, Lawrence SA, Stice JP, Spasojevic I, et al.SC-27316, 1:10,000; 441, SC-7305, 1:10,000), α-tubulin (E-19, SC-27316, 1:10,000), Topoisomerase 1 (C-21, SC-32736, 1:5,000), and HSP90 (F-8, SC-13119, 1:1,000) were purchased from Santa Cruz Biotechnology. Antibody

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Topo I (C-21) Antibody

Topo I (C-21) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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Topo I (C-21) Antibody from Santa Cruz Biotechnology, Inc.

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