The EGFR (Tyr845) Polyclonal Antibody, RBITC Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to EGFR, and epidermal growth factor receptor. This antibody recognizes Homo Sapiens, and Human antigen. The EGFR (Tyr845) Polyclonal Antibody, RBITC Conjugated has been shown to work in the following applications: Flow Cytometry, and Western Blot.
Description
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma