ORC2 (3G6) Antibody sc-32734 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemORC2 (3G6) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-32734
Antibody TypePrimary Antibodies
NCBI Gene AliasesORC2L
Quantity200 µg/ml
Clone3G6
Reactivityhuman
ApplicationsWB, IP
FormatPurified
ClonalityMonoclonal
Conjugate/TagUnconjugated
Hostrat
NCBI Full Gene Nameorigin recognition complex subunit 2
TargetORC2
IsotypeIgG2a

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) RNAs anchoring replication complex control initiation and firing of DNA replicationNature CommunicationsMay 27, 2026Simone Ummarino, Larysa Poluben, Alexander K. Ebralidze, Ida Autiero, Lucrezia Rinaldi, Theodore Paniza, Madhura Deshpande, Nicholas H. Mandel, Johnathan D. Lee, Yanzhou Zhang, et al.Anti-Cdc6 N-terminal (abcam Catalog No. ab188423); ORC2 (3G6) (Santa Cruz Biotechnology Catalog No. sc-32734). Recombinant proteins Recombinant human origin recognition complex subunit 1 (ORC1) (Cusabio Catalog

(2) Regulation of epigenetics and chromosome structure by human ORC2Cell ReportsJune 24, 2025Zhangli Su, Mengxue Tian, Etsuko Shibata, Yoshiyuki Shibata, Tianyi Yang, Zhenjia Wang, Fulai Jin, Chongzhi Zang, Anindya DuttaAntibodies used include α-ORC1 (cell signaling technology, no. 4731), α-ORC2 (Santa Cruz Biotechnology, no. sc-32734), α-ORC3 (Santa Cruz Biotechnology, no. sc-23888), α-ORC4, α-ORC5, α-ORC6 (home-made56), α-HSP90 (Santa Cruz Biotechnology

(3) Specific origin selection and excess functional MCM2-7 loading in ORC-deficient cellsNucleic Acids ResJune 18, 2025Yoshiyuki Shibata, Mihaela Peycheva, Etsuko Shibata, Daniel Malzl, Rushad Pavri, Anindya Duttaand sonicated (P3). Antibodies used were as follows: ORC1 (4731, Cell Signaling Technology), ORC2 (sc-32734, Santa Cruz Biotechnology or generous gift from Bruce Stillman, Cold Spring Harbor Laboratory), ORC3

(4) Identification of ATP-Competitive Human CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome FunctionMolecular cancer therapeuticsNovember 4, 2024Xiang S, Craig KC, Luo X, Welch DL, Ferreira RB, Lawrence HR, Lawrence NJ, Reed DR, Alexandrow MG.RRID:AB_2142526), anti-Mcm6 (sc55577, RRID:AB_831540), anti-Mcm7 (sc9966, RRID:AB_627235), anti-Orc2 (sc32734, RRID:AB_2157726), anti-Cdt1 (sc28262, RRID:AB_2076885), anti-Cdc6 (sc9964, RRID:AB_627236), antiphospho-Ser54-Cdc6

(5) NFIB facilitates replication licensing by acting as a genome organizerNat CommunAugust 21, 2023Wenting Zhang, Yue Wang, Yongjie Liu, Cuifang Liu, Yizhou Wang, Lin He, Xiao Cheng, Yani Peng, Lu Xia, Xiaodi Wu, et al.BrdU (anti-CldU, ab6326) from Abcam; MCM2 (3619, 1:1000 for WB) from Cell Signaling Technology; ΟRC2 (sc-32734, 1:500 for WB), Geminin (sc-74456, 1:1000 for WB), POLD1 (sc-17776, 1:1000 for WB) and β-actin (sc-47778,

(6) Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cellseLifeJuly 18, 2023Harada Y, Mizote Y, Suzuki T, Hirayama A, Ikeda S, Nishida M, Hiratsuka T, Ueda A, Imagawa Y, Maeda K, et al.

(7) Bromodomain protein BRD8 regulates cell cycle progression in colorectal cancer cells through a TIP60-independent regulation of the pre-RC complexiScienceApril 21, 2023Yamaguchi K, Nakagawa S, Saku A, Isobe Y, Yamaguchi R, Sheridan P, Takane K, Ikenoue T, Zhu C, Miura M, et al.

(8) Chromatin loading of MCM hexamers is associated with di-/tri-methylation of histone H4K20 toward S phase entryNucleic acids researchDecember 2, 2021Hayashi-Takanaka Y, Hayashi Y, Hirano Y, Miyawaki-Kuwakado A, Ohkawa Y, Obuse C, Kimura H, Haraguchi T, Hiraoka Y.

(9) Cockayne syndrome group A and ferrochelatase finely tune ribosomal gene transcription and its response to UV irradiationNucleic acids researchNovember 8, 2021Lanzafame M, Branca G, Landi C, Qiang M, Vaz B, Nardo T, Ferri D, Mura M, Iben S, Stefanini M, et al.

(10) SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibitionNature communicationsOctober 1, 2021Ma J, Shi Q, Cui G, Sheng H, Botuyan MV, Zhou Y, Yan Y, He Y, Wang L, Wang Y, et al.1:500), MCM7 (Santa Cruz, # sc-9966, 1:500), Cdc6 (Santa Cruz, # sc-9964, 1:500), ORC2 (Santa Cruz, # sc-32734, 1:500), HA.11 (Covance, #MMS-101R, 1:1000), BRD4 (Abcam, # ab1228874, 1:1000), SPOP (Proteintech Group,

(11) The presence of extra chromosomes leads to genomic instabilityNature communicationsFebruary 15, 2016Passerini V, Ozeri-Galai E, de Pagter MS, Donnelly N, Schmalbrock S, Kloosterman WP, Kerem B, Storchová Z.CDC6 (1:1,000; Santa Cruz sc-9964), ORC6 (1:1,000, Santa Cruz sc-32735), ORC2 (1:1,000, Santa Cruz sc-32734), RFC4 (1:1,000; Santa Cruz sc-20996), RFC5 (1:1,000; Bethyl A300-146A), PCNA (1:1,000; Chromotek 16d10)

(12) A Role of hIPI3 in DNA Replication Licensing in Human CellsPloS oneJanuary 1, 2016Huang Y, Amin A, Qin Y, Wang Z, Jiang H, Liang L, Shi L, Liang C.Anti-MCM4 (Santa Cruz, sc-9840, 1:1,500), Anti-MCM6 (Santa Cruz, sc-9845, 1:1,500), Anti-ORC2 (Santa Cruz, sc-32734, 1:1,500), Anti-ORC3 (Santa Cruz, sc-21862, 1:2,000), Anti-ORC4 (Santa Cruz, sc-19725, 1:2,000), Anti-Histone

(13) Suppression of the DHX9 helicase induces premature senescence in human diploid fibroblasts in a p53-dependent mannerThe Journal of biological chemistryAugust 15, 2014Lee T, Di Paola D, Malina A, Mills JR, Kreps A, Grosse F, Tang H, Zannis-Hadjopoulos M, Larsson O, Pelletier J.

(14) Ku protein levels, localization and association to replication origins in different stages of breast tumor progressionJournal of CancerJanuary 1, 2013Abdelbaqi K, Di Paola D, Rampakakis E, Zannis-Hadjopoulos M.following antibodies were used: anti-Ku70 (sc-1486), anti-Ku86 (sc-9034), anti-Orc1 (sc-23887), anti-Orc2 (sc-32734), anti-Orc3 (sc-21862), anti-Orc4 (sc-20634), anti-Orc5 (sc-19728), anti-Orc6 (sc-32735), anti-MCM7

(15) Comparative analysis of pre-replication complex proteins in transformed and normal cellsJournal of cellular biochemistryApril 1, 2012Di Paola D, Zannis-Hadjopoulos M.

(16) Differential chromatin structure encompassing replication origins in transformed and normal cellsGenes & cancerFebruary 1, 2012Di Paola D, Rampakakis E, Chan MK, Zannis-Hadjopoulos M.nonspecific adsorption to the beads, incubated for 6 hours with either 20 µg of anti-ORC2 (Santa Cruz, sc-32734)/(gift from Dr. Anindya Dutta), anti-Cdc6 (Santa Cruz, sc-8341), anti-Cdt1 (Santa Cruz, sc-28262), anti-histone H3

(17) Phosphorylation of SRSF1 is modulated by replicational stressNucleic acids researchFebruary 1, 2012Leva V, Giuliano S, Bardoni A, Camerini S, Crescenzi M, Lisa A, Biamonti G, Montecucco A.

(18) Increased origin activity in transformed versus normal cells: identification of novel protein players involved in DNA replication and cellular transformationNucleic acids researchApril 1, 2010Di Paola D, Rampakakis E, Chan MK, Arvanitis DN, Zannis-Hadjopoulos M.non-specific adsorption to the beads, incubated for 6 h with either 20 µg of anti-ORC2 (Santa Cruz, sc-32734), anti-cdc6 (Santa Cruz, sc-8341), anti-cdt1 (Santa Cruz, sc-28262), anti-EEF1D (gift from Dr. William

(19) The minimal replicator element of the Kaposi's sarcoma-associated herpesvirus terminal repeat supports replication in a semiconservative and cell-cycle-dependent mannerJournal of virologyApril 1, 2007Verma SC, Choudhuri T, Robertson ES.

(20) Latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus interacts with origin recognition complexes at the LANA binding sequence within the terminal repeatsJournal of virologyMarch 1, 2006Verma SC, Choudhuri T, Kaul R, Robertson ES.

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ORC2 (3G6) Antibody

ORC2 (3G6) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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ORC2 (3G6) Antibody from Santa Cruz Biotechnology, Inc.

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