IFI-16 (1G7) Antibody from Santa Cruz Biotechnology, Inc.

Yes, the IFI-16 (1G7) antibody has been shown to be effective in studies investigating the role of IFI16 in HIV-1 infections. For instance, it was utilized to demonstrate that an additional NF-κB binding site in the HIV-1 promoter allows subtype C strains to evade restriction by IFI16, highlighting its importance in viral replication and immune evasion mechanisms (bosso2021).

Yes, the IFI-16 antibody has been successfully used in immunofluorescence applications. In one study, it was employed to visualize the colocalization of IFI16 with DNA and the signaling molecule STING in cytokine-stimulated human keratinocytes, indicating its utility in studying innate immune responses (chiliver2014).

The IFI-16 antibody has been used to explore its role in p53-dependent apoptosis. Research indicates that IFI16 can synergistically induce apoptosis in cancer cells, and its degradation by STING negatively regulates this process, suggesting a complex interplay between these proteins in tumorigenesis (li2021).

Yes, the IFI-16 antibody has been utilized in research examining the innate immune response to influenza A virus. It was shown to be essential for activating programmed cell death pathways in infected cells, demonstrating its role as a sensor for viral RNA and its involvement in the antiviral immune response (mishra2022).