FANCD2 (FI17) Antibody sc-20022 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemFANCD2 (FI17) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-20022
NCBI Gene AliasesFA-D2, FA4, FACD, FAD, FAD2, FANCD
Antibody TypePrimary Antibodies
Reactivityhuman
CloneFI17
Quantity200 µg/ml
ApplicationsWB, IP, IF, IHC(P)
FormatPurified
ClonalityMonoclonal
Conjugate/TagUnconjugated
Hostmouse
NCBI Full Gene NameFA complementation group D2
TargetFANCD2
IsotypeIgG1

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) The DNA helicase HELQ promotes replication fork reversal in coordination with BRCA2- and FANCD2-mediated repair pathwaysNucleic Acids ResApril 29, 2026Yerkin Dunbayev, Yen-Ju Chen, Lorenzo Sassi, Eun A Lee, Jae Sun Ra, Moonjung Choi, Anirban Mukherjee, Karen M Vasquez, Vincenzo Costanzo, Peter Chi, et al.Santa Cruz Biotechnology, 1:200), BRCA2 (ab9143, Abcam, 1:1000), ZRANB3 (23111-1-AP, Proteintech, 1:500), FANCD2 (sc20022, Santa Cruz, 1:1000), α-Tubulin (T5168, Sigma–Aldrich, 1:5000), Vinculin (sc-73614, Santa Cruz, 1:5000),

(2) Inhibition of NAMPT targets DNA damage response to sensitize alkylating chemotherapy in TP53 mutant mantle cell lymphoma∗Blood AdvancesMarch 10, 2026Na Li, Yicen Liu, Linna Zhang, Saisai Guo, Zhihao Wu, Yan Xu, Ming Yang, Jixia Kong, Yuxuan Che, Kun Shao, et al.protein and phospho-specific isoforms using the following antibodies: FANCD2 (Santa Cruz Biotechnology, sc-20022), RAD51 (Santa Cruz Biotechnology, sc-398587), PBEF (Santa Cruz Biotechnology, sc-166946), cleaved Caspase3

(3) RNF20-mediated H2B monoubiquitination protects stalled forks from degradation and promotes fork restartEMBO ReportsJune 10, 2025Debanjali Bhattacharya, Harsh Kumar Dwivedi, Ganesh Nagaraju2348S Anti-CHK2 pT68 (for WB),Cell Signaling Technology,Cat# 2197 Anti-FANCD2 (for IF),Santa Cruz,Cat# sc20022 Anti-RPA32 pS4/8 (for WB),Bethyl,Cat# A300-245A Anti-SMARCAL1 (for WB),Abcam,Cat# ab-154226 Anti-ZRANB3

(4) PP2A licenses the FANCD2/FANCI complex for chromosome loadingCell ReportsNovember 12, 2024Di Yang, Fengxiang Bai, David Lopez Martinez, Hannan Xu, Ai Johjima-Murata, Lily Jiaqi Cao, Martin A. Cohnanalyzed by BD CellQuest. Antibodies Antibodies used were as follows: anti-FANCD2, 1:100 dilution (sc-20022, Santa Cruz Biotechnology); anti-FANCI, 1:500 dilution (FARF); anti-Flag, 1:1,000 dilution (M5, F4042,

(5) Contribution of p53-dependent and -independent mechanisms to upregulation of p21 in Fanconi anemiaPLOS GeneticsNovember 7, 2024Xavier Renaudin, Baraah Al Ahmad Nachar, Benedetta Mancini, Anna Gueiderikh, Noémie Louis-Joseph, Frédérique Maczkowiak-Chartois, Filippo Rosselliconducted 72 h later. Antibodies We used the following antibodies: mouse anti-FANCD2 (Santa Cruz; sc-20022), rabbit anti-p21 (Cell Signaling Technology; CST2947), FITC-conjugated anti-p21 (Cell Signaling Technology;

(6) The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistanceCellOctober 17, 2024Justin L. Engel, Xiao Zhang, Mingming Wu, Yan Wang, Jose Espejo Espejo Valle-Inclán, Qing Hu, Kidist S. Woldehawariat, Mathijs A. Sanders, Agata Smogorzewska, Jin Chen, et al.hr at RT or overnight at 4°C: anti-FANCD2 1:1,000 (Novus NB100-182), anti-FANCD2 1:100 (Santa Cruz sc-20022), anti-phospho-histone H2A.X (Ser139) 1:1,000 (Cell Signaling 2577), anti-phospho-histone H2A.X (Ser139)

(7) Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscapeMolecular CellApril 18, 2024Prajwal C. Boddu, Abhishek K. Gupta, Rahul Roy, Bárbara De La Peña Avalos, Anne Olazabal-Herrero, Nils Neuenkirchen, Joshua T. Zimmer, Namrata S. Chandhok, Darren King, Yasuhito Nannya, et al.antibody,Abcam,Cat#ab220827 Rabbit polyclonal FANCD2 antibody,Bethyl,Cat#A302-174A Mouse monoclonal FANCD2 antibody,Santa Cruz,Cat#sc-20022 Rabbit polyclonal UAP56/DDX39B antibody,Protein tech,Cat#14798-1-AP Rabbit polyclonal anti-ATR antibody,Bethyl,Cat#A300-137A Rabbit

(8) The Fanconi anemia core complex promotes CtIP-dependent end-resection to drive homologous recombination at DNA double-strand breaksbioRxivNovember 20, 2023Bert van de Kooij, Fenna J. van der Wal, Magdalena B. Rother, Pau Creixell, Merula Stout, Wouter Wiegant, Brian A. Joughin, Julia Vornberger, Marcel A.T.M. van Vugt, Matthias Altmeyer, et al.Target,Species,Company,Cat. No.,Application and dilution Ube2T,Rabbit,Abcam,ab140611,WB (1:1000) FANCD2,Mouse,Santa Cruz,sc-20022,IF (1:100) and WB (1:1000) Tubulin,Mouse,Sigma Aldrich,"T6199, clone DM1A",WB (1:5000) gH2AX,Mouse,Millipore,"#05-636,

(9) The abscission checkpoint senses chromatin bridges through Top2α recruitment to DNA knotsThe Journal of cell biologyNovember 6, 2023Petsalaki E, Balafouti S, Kyriazi AA, Zachos G.(G10; sc-390293), RFC4 (C-9; sc-28301), RFC5 (F9; sc-376528), TopBP1 (B-7; sc-271043), FANCD2 (FI17; sc-20022), and phospho-ATM-Ser1981 (10H11.E12; sc-47739) were from Santa Cruz Biotechnology. Rabbit polyclonal

(10) Mitotic DNA Synthesis in Untransformed Human Cells Preserves Common Fragile Site Stability via a FANCD2-Driven Mechanism That Requires HELQJournal of Molecular BiologyNovember 1, 2023Emma L. Traband, Sarah R. Hammerlund, Mohammad Shameem, Ananya Narayan, Sanjiv Ramana, Anika Tella, Alexandra Sobeck, Naoko ShimaPrimary antibodies for immunoblotting were used at the following dilutions; anti-FANCD2 (Santa Cruz sc-20022, 1:500), anti-FANCI (Millipore Sigma ABE1817, 1:500), anti-FANCL (proteintech, 66639-1-Ig, 1:1,000),

(11) The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflictsNature CommunicationsOctober 28, 2023Aleix Bayona-Feliu, Emilia Herrera-Moyano, Nibal Badra-Fajardo, Iván Galván-Femenía, María Eugenia Soler-Oliva, Andrés Aguileraincubated overnight at 4 °C with anti-γH2AX (Abcam ab2893, 1:1000) or anti-FANCD2 (Santa Cruz Biotechnlogy sc-20022, 1:100) in blocking solution, washed, and incubated again with the corresponding secondary antibodies

(12) FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stressMolecular cellOctober 19, 2023Brunner A, Li Q, Fisicaro S, Kourtesakis A, Viiliäinen J, Johansson HJ, Pandey V, Mayank AK, Lehtiö J, Wohlschlegel JA, et al.polyclonal FANCD2,Cell Signaling Technology,16323 Mouse monoclonal FANCD2,Santa Cruz Biotechnology,sc-20022 Rabbit polyclonal FANCI,Cell Signaling Technology,14657 Mouse monoclonal CYCLIN E,Santa Cruz Biotechnology,sc-247 Mouse

(13) Crosstalk of ferroptosis regulators and tumor immunity in pancreatic adenocarcinoma: novel perspective to mRNA vaccines and personalized immunotherapyApoptosis : an international journal on programmed cell deathOctober 1, 2023Shi Y, Wang Y, Dong H, Niu K, Zhang W, Feng K, Yang R, Zhang Y.confirmed by two pathologists independently. Regents as following: FANCD2: Santa Cruz Biotechnology Cat#sc-20022, RRID:AB_2278211, dilution 1:10. Western blotting Cells lysates and protease inhibitors lysed all

(14) Actionable loss of SLF2 drives B-cell lymphomagenesis and impairs the DNA damage responseEMBO molecular medicineSeptember 11, 2023Zhang L, Wirth M, Patra U, Stroh J, Isaakidis K, Rieger L, Kossatz S, Milanovic M, Zang C, Demel U, et al.,Cell Signaling,14475,"1:2,000" AURKB,Cell Signaling,3094,"1:2,000" PTTG‐1,Santa Cruz,sc‐56207,"1:1,000" FANCD2,Santa Cruz,sc‐20022,"1:1,000" SMC5,Invitrogen,PA5‐63037,"1:3,000" UbP4D1,Santa Cruz,sc‐8017,"1:1,000" SAE1,Abcam,ab185949,"1:1,000" SAE2,Abcam,ab185955,"1:1,000" ß‐Actin,SigmaAldrich,A1978,"1:5,000" ß‐Tubulin,DSHB,E7,0.4

(15) Comprehensive laboratory diagnosis of Fanconi anaemia: comparison of cellular and molecular analysisJournal of Medical GeneticsAugust 1, 2023Gaurav Joshi, Nancy Beryl Janet Arthur, Thenral S Geetha, Phaneendra Venkateswara Rao Datari, Kirti Modak, Debanjan Roy, Anurag Dutta Chaudhury, Prasanth Sundaraganesan, Sweety Priyanka, Fouzia NA, et al.Western blot was carried out using standard protocols using a FANCD2 antibody (Santa Cruz Biotechnology; sc-20022) to detect the presence or absence of FANCD2 monoubiquitination. Next-generation sequencing to identify

(16) Phosphorylation by ATR triggers FANCD2 chromatin loading and activates the Fanconi anemia pathwayCell reportsJuly 25, 2023Kupculak M, Bai F, Luo Q, Yoshikawa Y, Lopez-Martinez D, Xu H, Uphoff S, Cohn MA.crystal violet in methanol. Antibodies Antibodies used were as follows: anti-FANCD2, 1:100 dilution (sc-20022, Santa Cruz Biotechnology); anti-FANCI, 1:500 dilution (FARF); anti-Flag, 1:1,000 dilution (M5, F4042,

(17) Combinations of ivermectin with proteasome inhibitors induce synergistic lethality in multiple myelomaCancer lettersJuly 1, 2023Luo H, Feng Y, Wang F, Lin Z, Huang J, Li Q, Wang X, Liu X, Zhai X, Gao Q, et al.

(18) Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapyClinical and translational medicineMay 1, 2023Shapiro DD, Zacharias NM, Tripathi DN, Karki M, Bertocchio JP, Soeung M, He R, Westerman ME, Gao J, Rao P, et al.anti‐actin (Santa Cruz Biotechnology; sc‐47778), mouse monoclonal anti‐FANCD2 (Santa Cruz Biotechnology; sc‐20022) and mouse monoclonal anti‐ERCC1 (Santa Cruz Biotechnology; sc‐17809). Quantification of protein expression

(19) Differences of ferroptosis-related genes between White and Asian patients with liver cancerAmerican journal of cancer researchJanuary 1, 2023Xia P, Wen GM, Zheng XH, Zhao ZY.

(20) Fanconi anemia pathway regulation by FANCI in prostate cancerFrontiers in oncologyJanuary 1, 2023Kaljunen H, Taavitsainen S, Kaarijärvi R, Takala E, Paakinaho V, Nykter M, Bova GS, Ketola K.in a blocking buffer. For anti-FANCI (Cat. no. PA5-59014, Invitrogen) and for anti-FANCD2 (Cat. no. sc-20022, Santa Cruz Biotechnology, Dallas, TX, USA), dilution ratio 1:500 was used; for anti-FANCB (Cat. no.

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FANCD2 (FI17) Antibody

FANCD2 (FI17) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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FANCD2 (FI17) Antibody from Santa Cruz Biotechnology, Inc.

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