Cdk5 (J-3) Antibody sc-6247 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemCdk5 (J-3) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-6247
Antibody TypePrimary Antibodies
NCBI Gene AliasesPSSALRE, Crk6, LIS7
ApplicationsWB, IP, IF, ELISA
CloneJ-3
Quantity200 µg/ml
Reactivitymouse, rat, human
ClonalityMonoclonal
Hostmouse
Conjugate/TagUnconjugated
FormatPurified
NCBI Full Gene Namecyclin dependent kinase 5
TargetCdk5
IsotypeIgG2b

Questions and Answers

What applications has the Cdk5 (J-3) Antibody been used for in research?

The Cdk5 (J-3) Antibody has been shown to work in various applications including Western Blotting, ELISA, Immunofluorescence, and Immunoprecipitation, as evidenced by its use in multiple scientific studies.

Can this antibody be used in studies related to neurodegenerative diseases?

Yes, the Cdk5 (J-3) Antibody has been utilized in research focusing on neurodegenerative diseases. For instance, it was involved in studies examining the role of Cdk5 in neuronal apoptosis and excitotoxicity, highlighting its significance in neurodegenerative processes ().

Is the Cdk5 (J-3) Antibody effective in cancer research?

The Cdk5 (J-3) Antibody has been employed in cancer research, particularly in studies investigating the downregulation of PD-L1 in tumor cells through CRISPR-Cas9 technology, which enhances antitumor immunity ().

What species does the Cdk5 (J-3) Antibody react with?

The Cdk5 (J-3) Antibody is reactive with multiple species, including humans, mice, and rats, making it versatile for various experimental models in neuroscience and cancer research.

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) IL-18 binding protein attenuates neuroinflammation and cognitive decline in Alzheimer’s diseaseJournal of NeuroinflammationFebruary 27, 2026Dae Ki Hong, Seung Hoon Jeon, Minwoo Kang, Sowon Lee, Xia Liu, Eun Hee Ahn, Seong Su Kang,Santa Cruz,"SC-373,727",Anti-Mouse-IgG Anti-β-actin,Sigma-Aldrich,A1978,Anti-Mouse-IgG Anti-MAP-2,Sigma-Aldrich,M9942,Anti-Mouse-IgG Anti-GFAP,Millipore,MAB3402,Anti-Mouse-IgG Anti-Iba-1,Abcam,ab178846,Anti-Rabbit-IgG Anti-CDK-5,Santa Cruz,SC-6247,Anti-Mouse-IgG Anti-Cleaved caspase-3,Cell signaling,9661 S,Anti-Rabbit-IgG Anti-Caspase-1,AdipoGen,AG-20B-0042-C100,Anti-Mouse-IgG Anti-NLRP3,AdipoGen,AG-20B-0014-C100,Anti-Mouse-IgG Anti-MAO-A,Invitrogen,PA5-79623,Anti-Rabbit-IgG Anti-NeuN,Thermo

(2) The G2019S LRRK2 mutation exacerbates α-synuclein and tau neuropathology through divergent pathways in Parkinson's disease modelsActa neuropathologicaNovember 11, 2025Tsafaras G, Cabezudo D, Wetzels L, Tsakogias I, Abey A, Bentea E, Sanchiz-Calvo M, Van den Haute C, Wade-Martins R, Baekelandt V.phospho-GSK3β (Ser9) (rabbit, Cell Signalling, 9331S, 1:1000); Cdk5 (mouse, Santa Cruz Biotechnology, sc6247, 1:1000); PHF1 (mouse, provided by Peter Davis, 1:500); mc1 (mouse, provided by Peter Davis, 1:100);

(3) A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug ScreeningAdvanced Healthcare MaterialsOctober 9, 2025Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, et al.including rabbit anti‐p16‐INK4A polyclonal antibody (1:200) (Proteintech), mouse anti‐p21 antibody (1:100) (sc‐6247, Santa Cruz Biotechnology, TX, USA), rabbit anti‐Lamin B1 polyclonal antibody (1:1000) (12987‐1‐AP,

(4) Targeting a Tau Kinase Cdk5, Cyclin-Dependent Kinase: A Blood-Based Diagnostic Marker and Therapeutic Earmark for Alzheimer’s DiseaseBiomoleculesSeptember 26, 2025Sakshi Kumari, Abhinay Kumar Singh, Mukesh Kumar, Rashmita Pradhan, Abhijith R. Rao, Yudhishthir Yadav, Pramod Kumar, Partha Haldar, Punit Kaur, Sharmistha Deyantibodies, mouse IgG against human Cdk5 (Santa Cruz Biotechnology Inc., Dallas, TX, USA, cat. no. Sc6247) and rabbit IgG against human Mcl1 (Cell Signaling Technologies, cat. no. CST-45725), were immobilized

(5) Activity-dependent phosphorylation of CDYL by CDK5 regulates fear memory in miceTransl PsychiatryAugust 30, 2025Na-Yun Lyu, Guo-Guang Xie, Zhi-Wen Hu, Tian-Jie Lyu, Rui Qin, Lu Chen, Yun Wangcommercial antibodies were anti-β-actin (ZSGB-BIO, #TA09, Beijing, China), anti-CDK5 (Santa Cruz, #sc-6247, CA, USA), anti-CDYL (ABclonal, #WG-03686, Wuhan, China), anti-CDYL (Proteintech, #17763-1-AP, IL, USA),

(6) CDK5-mediated hyperphosphorylation of Tau217 impairs neuronal synaptic structure and exacerbates cognitive impairment in Alzheimer’s diseaseTransl PsychiatryAugust 21, 2025Kangyue Fu, Nan Lin, Yiwen Xu, En Huang, Raoli He, Zhixin Wu, Dianbo Qu, Xiaochun Chen, Tianwen Huangsc-820, Santa Cruz Biotechnology, USA), Anti-FLAG M2 (1:1000, CAT#: F1804, Sigma), Cdk5 (1:1000, CAT#: sc-6247, Santa Cruz Biotechnology), Drebrin (1:1000, CAT#: ab60933; Abcam), PSD95 (1:1000, CAT#: ab18258; Abcam)

(7) Engineering a Cell-Based Orthogonal Ubiquitin Transfer Cascade for Profiling the Substrates of RBR E3 ParkiniScienceJuly 18, 2025Shuai Fang, Li Zhou, Geng Chen, Jing Zhang, Xiaoyu Wang, In Ho Jeong, Savannah E. Jacobs, Bradley R. Kossmann, Wei Wei, Shu Liu, et al.RESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies ,, anti-CDK5 antibody,Santa Cruz Biotechnology,Cat# sc-6247 anti-myc antibody,Santa Cruz Biotechnology,Cat# sc-40 anti-Rab5a antibody,Santa Cruz Biotechnology,Cat#

(8) A new pathway for neuroprotection against tau hyperphosphorylation via δ-opioid receptor initiated inhibition of CDK5 and AMPK signalingFrontiers in Aging NeuroscienceJune 24, 2025Jiahui Li, Yuan Xu, Gianfranco Balboni, Ying Xia#14220, Cell Signaling Technology), β-actin (1:2000, #4970, Cell Signaling Technology), CDK5 (1:2000, sc-6247, Santa Cruz), CyclinD1 (1:2000, sc-8396, Santa Cruz), and CyclinB1 (1:2000, sc-245, Santa Cruz). After

(9) CDK5–cyclin B1 regulates mitotic fidelityNatureSeptember 26, 2024Xiao-Feng Zheng, Aniruddha Sarkar, Humphrey Lotana, Aleem Syed, Huy Nguyen, Richard G. Ivey, Jacob J. Kennedy, Jeffrey R. Whiteaker, Bartłomiej Tomasik, Kaimeng Huang, et al.for IB; rabbit CDK5 [EP715Y] Abcam ab40773 1:200 for IF; 1:1,000 for IB; mouseCDK5 (J-3) Santa Cruz sc-6247 1:500 for IB; mouse CDK5 (DC 17) Santa Cruz sc-249 AC, 25μL slurry used per mg of lysate for IP; human

(10) Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in miceiScienceFebruary 16, 2024Takahiro Eguchi, Tohru Tezuka, Yuji Watanabe, Akane Inoue-Yamauchi, Hiroshi Sagara, Manabu Ozawa, Yuji Yamanashianti-GAPDH,Cell Signaling Technology,Cat# 2118; RRID:AB_561053 Mouse anti-Cdk5,Santa Cruz Biotechnology,Cat# sc-6247; RRID:AB_627241 Rabbit Anti-p35/25,Cell Signaling Technology,"Cat# 2680, RRID:AB_1078214" Mouse Anti-FLAG,Merck,"Cat#

(11) Regulation of interferon alpha production by the MAGUK-family protein CASK under H5N1 infectionFrontiers in immunologyJanuary 1, 2024Huang JY, Sung PS, Hsieh SL.PAB27198 (for IP)" Anti-HCK,mouse,3D12E10,"Santa Cruz, 101428 (for IF)" Anti-CDK5,mouse,J3,"Santa Cruz, sc-6247 (for IP)" Anti-GFP,rabbit,polyclonal,"Abcam, ab290 (for IP)" Anti-GAPDH,mouse,6C5,"Sigma, MAB374 (for WB

(12) CDK5 promotes apoptosis and attenuates chemoresistance in gastric cancer via E2F1 signalingCancer Cell InternationalNovember 21, 2023Long-Long Cao, Yu-Kai Wu, Tong-Xin Lin, Mi Lin, Yu-Jing Chen, Ling-Qian Wang, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, et al.(Thermo Scientific, Waltham, MA, USA). The following primary antibodies were used: mouse anti-CDK5 (1:1000; sc-6247) and mouse anti-DP1 (1:1000; sc-53,642), purchased from Santa Cruz Biotechnology (Dallas, TX, USA).

(13) NPC1-dependent alterations in K(V)2.1-Ca(V)1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C diseaseNature communicationsJuly 28, 2023Casas M, Murray KD, Hino K, Vierra NC, Simó S, Trimmer JS, Dixon RE, Dickson EJ.(NeuroMab, K89/34), CaV1.2 at 1:250 (Alomone Labs, acc-003), CDK5 at 1:100 (Santa Cruz Biotechnology, Cat #sc-6247), p35 at 1:100 (Cell Signaling Technology, Cat #C64B10), p39 at 1:100 (Santa Cruz Biotechnology, Cat

(14) Phosphorylation of the Human DNA Glycosylase NEIL2 Is Affected by Oxidative Stress and Modulates Its ActivityAntioxidants (Basel, Switzerland)February 2, 2023Myrup Holst C, Brøndum Andersen N, Thinggaard V, Tilken M, Lautrup S, Tesauro C, Stevnsner T.

(15) New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217)International journal of molecular sciencesJanuary 12, 2023Li S, Han LL, Huang KP, Ma YH, Guo LL, Guo Y, Ran X, Yao YG, Hao XJ, Luo R, et al.antibodies were BACE1 (Cell Signaling Technology, 5606, Danvers, MA, USA), CDK5 (Santa Cruz Biotechnology, sc-6247, Dallas, TX, USA), GSK3β (D5C5Z) (Cell Signaling Technology, 12456), GAPDH (glyceraldehyde-3-phosphate

(16) APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic miceFrontiers in cellular neuroscienceJanuary 1, 2023Baltissen D, Bold CS, Rehra L, Banićević M, Fricke J, Just J, Ludewig S, Buchholz CJ, Korte M, Müller UC.

(17) Role of cyclin-dependent kinase 5 in psychosis and the modulatory effects of cannabinoidsNeurobiology of diseaseJanuary 1, 2023Barrera-Conde M, Veza-Estévez E, Gomis-Gonzalez M, Garcia-Quintana J, Trabsa A, Martínez-Sadurní L, Pujades M, Perez V, de la Torre R, Bergé D, et al.

(18) Monoterpenoid indole alkaloid dimers from Kopsia arborea inhibit cyclin-dependent kinase 5 and tau phosphorylationPhytochemistryNovember 1, 2022Chen C, Liu JW, Guo LL, Xiong F, Ran XQ, Guo YR, Yao YG, Hao XJ, Luo RC, Zhang Y.

(19) Crry silencing alleviates Alzheimer's disease injury by regulating neuroinflammatory cytokines and the complement systemNeural regeneration researchAugust 1, 2022Zhu XC, Liu L, Dai WZ, Ma T.monoclonal,sc-293136,"Santa Cruz Biotechnology, Santa Cruz, CA, USA" CDK5,1:1000,AB_627241,Mouse monoclonal,sc-6247,"Santa Cruz Biotechnology, Santa Cruz, CA, USA" Synaptophysin,1:1000,AB_2286949,Rabbit monoclonal,ab32127,"Abcam,

(20) Somatic Genetics Analysis of Sleep in Adult MiceThe Journal of neuroscience : the official journal of the Society for NeuroscienceJuly 13, 2022Wang G, Li Q, Xu J, Zhao S, Zhou R, Chen Z, Jiang W, Gao X, Zhou S, Chen Z, et al.commercial sources: anti-CREB (CST, 9197S), anti-CRTC1 (CST, C71D11), anti-CDK5 (Santa Cruz Biotechnology, sc-6247), anti-NeuN (Milipore, ABN78), anti-β-actin (Beyotime, AF003), anti-tubulin J (CST, 5568), anti-GFP

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Cdk5 (J-3) Antibody

Cdk5 (J-3) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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Cdk5 (J-3) Antibody from Santa Cruz Biotechnology, Inc.

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