GADD 45α (C-4) Antibody sc-6850 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemGADD 45α (C-4) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-6850
NCBI Gene AliasesDDIT1, GADD45, Ddit1
Antibody TypePrimary Antibodies
ApplicationsWB, IP, IF, FCM, ELISA
Quantity200 µg/ml
CloneC-4
Reactivitymouse, rat, human
Hostmouse
FormatPurified
ClonalityMonoclonal
Conjugate/TagUnconjugated
NCBI Full Gene Namegrowth arrest and DNA damage inducible alpha, growth arrest and DNA-damage-inducible 45 alpha
TargetGADD 45alpha
IsotypeIgG1

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Genotype-Encoded UV Sensitivity in iPSC-Derived Human Melanocytes Reveals MX2 as a Physiological Amplifier of p53/p38-Mediated DNA Damage SignalingInt J Mol SciMarch 12, 2026Eric Ramirez-Salazar, Ana Slipicevic, Marina Juraleviciute, Ling Li, Mark Harland, Sally O'Shea, Sinead Field, Julia Newton-Bishop, Meenhard Herlynphospho-p38 MAPK thr180/tyr182 (#4631) 1:1000; Santa Cruz Biotechnology (Dallas, TX, USA): GADD45α (sc-6850) 1:1000, p53 (sc-126); Novus Biologicals (Littleton, CO, USA): MX2 (NBP1-81018) 1:2000; Abcam (Cambridge,

(2) Sappanchalcone suppresses NSCLC by oxidative stress-driven DNA damage and ER stress activation through PIEZO1 modulationiScienceDecember 19, 2025Weiyu Wu, Ren Zhang, Geer Chen, Ziyu Chen, Zicong Lin, Yin Chen, Jiaqi Li, Weilin Liao, Junyi Wang, Xiaoxuan Wang, et al.,Santa Cruz,Cat#sc-517348; RRID: AB_2783871 anti-p21,Santa Cruz,Cat#sc-817; RRID: AB_2783871 anti-GADD45α,Santa Cruz,Cat#sc-6850; RRID: AB_627653 anti-GAPDH,Santa Cruz,Cat#sc-47724; RRID: AB_627678 anti-CDC2,Cell Signaling Technology,Cat#9116;

(3) GADD45A is Essential for Granulosa Cells Differentiation and Ovarian Reserve in Human and MiceJournal of Cellular and Molecular MedicineSeptember 7, 2025Juncen Guo, Yuanyuan Hu, Qi Cao, Ying Zhang, Yihe Jia, Lan Liu, Yanru Zeng, Xiao Wu, Yuelin Song, Maosen Yang, et al.in 5% milk for 1 h at room temperature, then washed and incubated with primary antibodies (GADD45A (sc‐6850, Santa Cruz Biotechnology, Santa Cruz, USA), FSHR (340,416, Zenbio, Chengdu, China), CYP19A1 (R381716,

(4) Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128Neural regeneration researchNovember 1, 2024Bellver-Sanchis A, Ávila-López PA, Tic I, Valle-García D, Ribalta-Vilella M, Labrador L, Banerjee DR, Guerrero A, Casadesus G, Poulard C, et al.USA/574597/AB_2255005",1:1000 GSH,Rabbit,"Abcam, Waltham, MA, USA/ab124811/AB_10973222",1:1000 GADD45a,Mouse,"Santa Cruz Biotechnology, TX, USA/sc-6850/AB_627653",1:500 BCL-2,Rabbit,Cell Signaling Technology/2870/AB_2290370,1:1000 BAX,Rabbit,Cell Signaling Technology

(5) Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian InsufficiencyAging DisApril 1, 2024Feiyan Zhao, Long Yan, Xuehan Zhao, Jiaqi Wu, Ying Fang, Zhimin Xin, Hongmei Wang, Xiaokui Yang(1:200; ab27591; Abcam), Foxl2 (1:100; ab5096; Abcam), γ-H2A.X (1:200; ab81299; Abcam), GADD45A (1:100; sc-6850, Santa Cruz Biotech) overnight at 4°C. After PBS washes, they were incubated with corresponding secondary

(6) Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian Insufficiencyaging and diseaseApril 1, 2024Feiyan Zhao, Long Yan, Xuehan Zhao, Jiaqi Wu, Ying Fang, Zhimin Xin, Hongmei Wang, Xiaokui Yang(1:200; ab27591; Abcam), Foxl2 (1:100; ab5096; Abcam), γ-H2A.X (1:200; ab81299; Abcam), GADD45A (1:100; sc-6850, Santa Cruz Biotech) overnight at 4°C. After PBS washes, they were incubated with corresponding secondary

(7) RGC-specific ATF4 and/or CHOP deletion rescues glaucomatous neurodegeneration and visual functionMolecular therapy. Nucleic acidsSeptember 12, 2023Fang F, Liu P, Huang H, Feng X, Li L, Sun Y, Kaufman RJ, Hu Y.were as follows: anti-RBPMS at 1:4,000 (Custom made at ProSci) and anti-GADD45a at 1:200 (Santa Cruz, sc-6850). Secondary antibodies were then applied (1:200; Jackson ImmunoResearch, West Grove, Pennsylvania) and

(8) Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathwayChinese journal of natural medicinesJanuary 1, 2023Wang M, Tian B, Shen J, Xu S, Liu C, Guan L, Guo M, Dou J.

(9) NF-κB1 p50 stabilizes HIF-1α protein through suppression of ATG7-dependent autophagyCell death & diseaseDecember 27, 2022Zhu J, Huang S, Li Y, Xu J, Chen R, Guo M, Qian X, Li T, Tian Z, Jin H, et al.purchased from Novus Biologicals, Inc. (Littleton, CO) (APR07745G); The antibodies against GADD45α (sc-6850), p65 (sc-8008), p50 (sc-8414), NCL (sc-55486), Sp1 (sc-420) were obtained from Santa Cruz Biotechnology Inc

(10) BCAS3 accelerates glioblastoma tumorigenesis by restraining the P53/GADD45α signaling pathwayExperimental cell researchAugust 15, 2022Wang Y, Li Y, Sun Q, Yuan F, Xu Y, Tong S, Li Y, Yi S, Yan T, Chen Q, et al.

(11) miR-1307 promotes hepatocarcinogenesis by CALR-OSTC-endoplasmic reticulum protein folding pathwayiScienceNovember 19, 2021Xie S, Jiang X, Qin R, Song S, Lu Y, Wang L, Chen Y, Lu D.

(12) Hydrogen sulfide suppresses the proliferation of intestinal epithelial cells through cell cycle arrestArchives of biochemistry and biophysicsNovember 15, 2021Xu W, Watanabe K, Mizukami Y, Yamamoto Y, Suzuki T.

(13) PB01 suppresses radio-resistance by regulating ATR signaling in human non-small-cell lung cancer cellsScientific reportsJune 8, 2021Kim TW, Hong DW, Hong SH.eIF2ɑ (Santa Cruz, 1:1000, sc-133132), JNK (Santa Cruz, 1:1000, sc-7345), GADD45ɑ (Santa Cruz, 1:1000, sc-6850), BAX (Santa Cruz, 1:1000, sc-7480), VDAC (Santa Cruz, 1:1000, sc-390996), and GRP78 (Santa Cruz, 1:1000,

(14) Aegle marmelos extract rich in marmelosin exacted ameliorative effect against chromium-induced oxidative stress and apoptosis through regulation of Gadd45 in HepG2 cell lineJournal of food biochemistryApril 1, 2021Katram N, Garlapati PK, Yadavalli C, Methal RE, Rajappa SBG, Raghavan AK.

(15) Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiationNature communicationsFebruary 16, 2021Dobersch S, Rubio K, Singh I, Günther S, Graumann J, Cordero J, Castillo-Negrete R, Huynh MB, Mehta A, Braubach P, et al.

(16) Function of DHX33 in promoting Warburg effect via regulation of glycolytic genesJournal of cellular physiologyFebruary 1, 2021Peng C, Hou ST, Deng CX, Zhang Y.

(17) GADD45α drives brown adipose tissue formation through upregulating PPARγ in miceCell death & diseaseJuly 27, 2020You W, Xu Z, Sun Y, Valencak TG, Wang Y, Shan T.

(18) DHX33 Recruits Gadd45a To Cause DNA Demethylation and Regulates a Subset of Gene TranscriptionMolecular and cellular biologyJune 15, 2020Feng W, Chen S, Wang J, Wang X, Chen H, Ning W, Zhang Y.(A300-800A); anti-pPOL II (phosphorylation on S2, for ChIP analysis), Abcam (ab-5095); anti-Gadd45a (sc-6850, for Western blotting and immunoprecipitation), Santa Cruz Biotechnology; anti-Gadd45a (ab180768, for

(19) A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injuryNature communicationsApril 21, 2020Kim JY, Bai Y, Jayne LA, Hector RD, Persaud AK, Ong SS, Rojesh S, Raj R, Feng MJHH, Chung S, et al.

(20) Cyclin D1 depletion interferes with oxidative balance and promotes cancer cell senescenceJournal of cell scienceJune 25, 2018Laphanuwat P, Likasitwatanakul P, Sittithumcharee G, Thaphaengphan A, Chomanee N, Suppramote O, Ketaroonrut N, Charngkaew K, Lam EW, Okada S, et al.antiHSP90 (sc-13119), mouse anti-total p38 (sc-535), mouse anti-total cJUN (sc-74543), mouse anti-GADD45 (sc-6850), and mouse anti-Cdk2 (sc6248) were purchased from Santa Cruz Biotechnology. Rabbit antiFOXO3a (07-702),

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GADD 45α (C-4) Antibody

GADD 45α (C-4) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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GADD 45α (C-4) Antibody from Santa Cruz Biotechnology, Inc.

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