The Cryopyrin Polyclonal Antibody, RBITC Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to NLRP3. This antibody recognizes Homo Sapiens, Human, Mouse, Rat, and Canine antigen. The Cryopyrin Polyclonal Antibody, RBITC Conjugated has been shown to work in the following applications: Immunofluorescence, and Western Blot.
Description
May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18