Fibronectin (EP5) Antibody sc-8422 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemFibronectin (EP5) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-8422
NCBI Gene AliasesLETS, ED-B, CIG, GFND, FNZ, FN, GFND2, Fn, MSF, FINC, E330027I09, Fn-1, SMDCF
Antibody TypePrimary Antibodies
Reactivitymouse, rat, human
Quantity200 µg/ml
CloneEP5
ApplicationsWB, IP, IF, IHC(P), ELISA
ClonalityMonoclonal
Hostmouse
Conjugate/TagUnconjugated
FormatPurified
NCBI Full Gene Namefibronectin 1
TargetFibronectin
IsotypeIgG1

Questions and Answers

What applications has the Fibronectin (EP5) antibody been used for in scientific research?

The Fibronectin (EP5) antibody has been shown to work in various applications including Western Blotting, ELISA, Immunofluorescence, Immunohistochemistry, and Immunoprecipitation. It has been utilized in studies to assess fibronectin expression in different cellular contexts, such as in the differentiation of HepaRG cells and in cancer research involving epithelial-mesenchymal transition.

Can this antibody be used to study fibronectin's role in cancer metastasis?

Yes, the Fibronectin (EP5) antibody has been referenced in studies investigating its role in cancer metastasis. For instance, it was used in research examining the effects of the p34(SEI-1) oncoprotein on cancer cell migration and invasion, highlighting the importance of fibronectin in these processes ().

Is the Fibronectin (EP5) antibody effective in immunohistochemistry for detecting fibronectin in tissue samples?

The Fibronectin (EP5) antibody has been effectively used in immunohistochemistry to detect fibronectin expression in various tissue samples, including studies that assessed fibronectin levels in the context of drug-induced liver injury and other pathological conditions ().

What species does the Fibronectin (EP5) antibody react with?

The Fibronectin (EP5) antibody is reactive with multiple species, including humans (Homo sapiens), mice (Mus musculus), and rats (Rattus norvegicus), making it versatile for studies across different model organisms.

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Porphyromonas gingivalis secreted factors drive epithelial-mesenchymal transition (EMT) through gingipains and an H2S-mediated bacterial defense systemGut MicrobesDecember 31, 2026Michal Kazelnik, Rana Masri, Michal Caspi, Amnon Wittenstein, Ilan Tsarfaty, Elhanan Borenstein, Tal Caller, Konstantin Shatalin, Evgeny Nudler, Rina Rosin-ArbesfeldVimentin (D21H3) Rabbit Monoclonal Antibody #5741; (1:1000, Cell Signaling), Fibronectin Antibody (EP5): sc-8422 (1:1000, Santa Cruz), Collagen1clone 5D8-G9 #MAB3391 (1:1000), Integrin a5 (C-9): sc-376199 (1:1000,

(2) Thermoreversible cell-derived extracellular matrix only hydrogel (CEOgel): Development, characterization, and applicationsMaterials Today BioJune 1, 2026Byoungha An, Jae Won Kwon, Heejeong Yoon, Tae-Eun Park, Seung Won Yang, Kwideok Park1:500), rabbit polyclonal anti-laminin (L9393, Sigma-Aldrich, 1:100), mouse monoclonal anti-fibronectin (SC-8422; Santa Cruz Biotechnology, 1:200), Alexa Fluor® 488-conjugated goat anti-rabbit IgG (A-11008; Invitrogen,

(3) Targeting FN1 to overcome gemcitabine resistance in gallbladder cancer: Mechanistic insights and an iRGD-modified PEG-PLGA nanoparticle delivery strategyMaterials Today BioApril 1, 2026Maojin Tian, Xiangwei Meng, Weiwei Song, Zhengyu Wu, Yang Liu, Xianing Dong, Shuai Ren, Juan Du, Peiqing ZhaoIgG controls were subjected to SDS-PAGE and WB. Detection antibodies included mouse anti-FN1 (1:1000; sc-8422, Santa Cruz, USA), mouse anti-PI3K p85 (1:1000; ab189403, Abcam, UK), and rabbit anti-AKT (1:1000; 4691,

(4) Disrupting the TGF-β-regulated epithelial-mesenchymal transition, apoptotic and autophagic phenotypes of 3D glioblastoma spheroids via glycolytic inhibitionExploration of Targeted Anti-tumor TherapyMarch 30, 2026Maellis Payet-Desruisseaux, Alain Zgheib, Bogdan Alexandru Danalache, Michel Desjarlais, Borhane AnnabiPierce (Rockford, IL, USA). The rabbit polyclonal antibody against GRP78 (SC-13968) and fibronectin (SC-8422) was from Santa Cruz Biotechnology (Dallas, TX, USA). Polyclonal antibodies against TGF-β (56E4, 3709

(5) Targeting CRBN With Thalidomide Suppresses Fibrosis After Glaucoma Drainage Surgery Through NF-κB Pathway InhibitionInvest Ophthalmol Vis SciMarch 20, 2026Lijun Wang, Hongsong Li, Lei Xiong, Chao Sun, Jianming Wanganti-PCNA (1:500, sc-56; Santa Cruz Biotechnology, Dallas, TX, USA), anti-fibronectin (FN) (1:200, sc-8422; Santa Cruz Biotechnology), anti-P65 (1:1000, no. 4764; Cell Signaling Technology, Danvers, MA, USA),

(6) Metabolomics Reveals the Anti-hepatic Fibrosis Mechanisms of Pueraria lobata (Willd.) Ohwi Extract and Potential Metabolites AlterationsInternational Journal of Medical SciencesMarch 17, 2026Yu-Ju Chen, Lo-Yun Chen, Ngoc-Thac Pham, John Louie Dela Vega, Federica Fulgheri, Ching-Chiung Wang, Maria Letizia Manca, Chia-Jung Leepreviously established protocol. The antibodies employed in this study included Fibronectin (Santa Cruz, sc-8422), Collagen Type I (Proteintech, 14695-1-AP), α-SMA (Proteintech, 14395-1-AP), MMP-3 (Santa Cruz, sc-21732),

(7) Sildenafil suppresses the activation of hypertrophic scar fibroblasts by promoting the KLF15-mediated inhibition of LOXL1 transcriptionThe Korean Journal of Physiology & PharmacologyMarch 1, 2026Caihua Li, Yi Xu, Bin Cao, Ye Fan, Jie Bin, Xiuping Wang, Churuo Zengfrom Thermo Fisher Scientific; Collagen I (1:1,000, Cat# sc-293182), and fibronectin (1:1,000, Cat# sc-8422) were purchased from Santa Cruz Biotechnology. p-SMAD2 (1:1,000, ser465/467, Cat# 3108), p-SMAD3 (1:1,000,

(8) Transglutaminase 2 exacerbates ovarian cancer survival by directly inactivating GSK3βCell Death DisFebruary 2, 2026Ho Lee, Joon Hee Kang, Hyun Jung Kim, Kyun Heo, Mi Kyung Park, Jeong Hwan Park, Byung Il Lee, Jong In Yook, Soo-Youl Kimpurchased from Thermo Scientific; anti-β-actin (#sc-47778), anti-N-cadherin (#sc-7939), anti-Fibronectin (#sc-8422), anti-Vimentin (#sc-6260) and anti-HA-tag (#sc-7392) were from Santa Cruz Biotechnology (Dallas, TX,

(9) Dynamic profiling of BMSC-dECM reveals accumulation of core matrisome proteins suppresses osteogenic differentiation and bone regenerationJournal of Advanced ResearchFebruary 1, 2026Mei Li, Weilai Zhu, Mingyu Hu, Xufeng Mao, Bowen Weng, Jing Peng, Shuishui Yin, Haijiao Mao, Jiyuan ZhaoPBS) at room temperature for 1 h. The following primary antibodies were diluted in 1 % BSA/PBS: FN (SC-8422, Santa Cruz Biotechnology, Shanghai, China) (1:50); COL1A1 (A16891, ABclonal, Wuhan, China) (1:100);

(10) Delactylase effects of SIRT3 on a positive feedback loop involving the RUNX1-glycolysis-histone lactylation in diabetic kidney diseaseInternational Journal of Biological SciencesJanuary 15, 2026Siman Shen, Chen Ying, Xinglin Fu, Xiaobian Zeng, Xiuli Guo, Han Wu, Liangqing Zhang, Li XuRUNX1 (sc-365644, Santa Cruz Biotechnology), HK1 (ab150423, Abcam), SLC2A1 (MAB1418, R&D Systems), FN (sc-8422, Santa Cruz Biotechnology), αSMA (NB300-978, Novus Biologicals) then incubated with the secondary antibodies

(11) Integrating Network Pharmacology, Machine Learning, and Experimental Validation to Elucidate the Mechanism of Cardamonin in Treating Idiopathic Pulmonary FibrosisInternational Journal of Molecular SciencesDecember 25, 2025Wenyue Zhang, Yi Guo, Qiushi Wang, Kai Wang, Huning Zhang, Sirong Chang, Anning Yang, Zhihong Liu, Yue SunAnti-α-SMA (ab5694, abcam, Cambridge, UK) for detection of α-smooth muscle actin (IF). Anti-fibronectin (sc-8422, Santa Cruz Biotechnology, Dallas, TX, USA) for detection of fibronectin (IF). Anti-E-cadherin (20874-1-AP,

(12) Extracellular ERp57 promotes fibronectin fibril formation during matrix assembly of articular cartilageiScienceDecember 19, 2025Yvonne Rellmann, Elco Eidhof, Uwe Hansen, Sandra Schulte, Sina Stücker, Thomas Pap, Rita Dreierdiluted in 2 % BSA/PBS. To analyze FN1 in the newly generated ECM, antibodies against fibronectin (sc-8422, monoclonal, from mouse, Santa Cruz, Dallas, USA, 1:50 or F3648, polyclonal, from rabbit, Merck Darmstadt,

(13) The Therapeutic Effect of a Biodegradable Long-Acting Intravitreal Implant Containing CGK012 on Neovascular Age-Related Macular Degeneration by Promoting β-Catenin DegradationPharmaceuticals (Basel)December 12, 2025Seoyoung Park, Jihyun Won, Jong Beom Heo, Juhyung Kang, Ye Woon Oh, Geunji Park, Giseong Lee, Jee-Hyun Lee, Gyu-Yong Song, Wonku Kang, et al.Technology), anti-vimentin (sc-7557, 1:1000; Santa Cruz Biotechnology, Dallas, TX, USA) and anti-fibronectin (sc-8422, 1:1000; Santa Cruz Biotechnology). Anti-VEGF (A5708, 1:1000), anti-NF-κB (p65) (A2547, 1:1000), anti-TNF-α

(14) Extracellular Domain Shedding of TROP2 Activates EGFR Signaling to Drive Prostate Cancer MetastasisCancer researchDecember 1, 2025Liu S, Hsu EC, Aslan M, Garcia-Marques F, Shen M, Hartono AB, Solano F, Le K, Hwang H, Lee CS, et al.(Cell Signaling Technology Cat# 12698, RRID:AB_2744546, 1:100); anti-Fibronectin (Santa Cruz Biotechnology Cat# sc-8422, RRID:AB_627598, 1:100); anti-COL1A1 (Santa Cruz Biotechnology Cat# sc-293182, RRID:AB_2797597, 1:100)]

(15) Aloe‐Emodin Targeting FOXC2 Disrupts NETs Formation and EMT‐Driven Postoperative Peritoneal Adhesion Through TGF‐β1‐Smad2/3 PathwayAdvanced ScienceOctober 13, 2025Lili Yang, Yunda Fang, Yuheng Lian, Ziyang Kong, Jia Miao, Yanqi Chen, Wen Li, Feiyan Chen, Bin Zhang, Yao Chen, et al.purchased from Yuanye Co., Ltd. The primary antibodies, such as α‐SMA (bs‐10196R, Bioss), Fibronectin (sc‐8422, Santa Cruz), FOXC2 (sc‐515472, Santa Cruz; 23066‐1‐AP, Proteintech), E‐cadherin (bs‐1519R, Bioss),

(16) Revisiting IGF2BP1 in Endometrial Cancer: Ethnic-Specific Prognostic Implications and Association with Caspase-3 and pSTAT3Journal of CancerSeptember 29, 2025Hua Ho, Ching-Yu Shih, Chiao-Yin Cheng, Yao-Jen Liang, Yen-Lin Chen250590), E-cadherin (Abcam, UK, ab40772), N-cadherin (Abcam, UK, ab76011), Fibronectin (Santa Cruz, USA, SC-8422), pAkt (GeneTex, USA, GTX11901), pErk (R&D Systems, USA, AF1018), pStat3 (Abcam, UK, ab76315), and pAMPK

(17) SDC2 and FN as cargo proteins in circulating extracellular vesicles in obese breast cancer patients with lymph node metastasisScientific ReportsSeptember 12, 2025Liali Yousef Talat, Ghada Mohamed, Maher H. Ibraheem, Amr Ahmed WalyEldeen, Hebatallah Hassan, Sherif Abdelaziz Ibrahim(Santa-Cruz (H-70): sc-11397), Syndecan-2 (Santa-Cruz (M-140): sc-15348) and Fibronectin (Santa-Cruz (EP5): sc-8422). After washing two times for 5 min and one time for 20 min with TBST, the membranes were incubated

(18) Attenuation of Pulmonary Fibrosis by the MyD88 Inhibitor TJ-M2010-5 Through Autophagy Induction in MiceBiomedicinesSeptember 10, 2025Yang Yang, Zeyang Li, Minghui Zhao, Yuanyuan Zhao, Zhimiao Zou, Yalong Xie, Limin Zhang, Dunfeng Du, Ping Zhouwere incubated with primary antibodies against α-SMA (#19245, CST, Beverly, MA, USA), fibronectin (FN, sc-8422, Santa Cruz Biotechnology, Santa Cruz, CA, USA), and COL1A1 (A16891, Abclonal, Wuhan, China); a detailed

(19) β-Caryophyllene Ameliorates Thioacetamide-Induced Liver Fibrosis in Rats: A Preventative ApproachInternational Journal of Molecular SciencesSeptember 1, 2025Lujain Bader Eddin, Amar Mahgoub, Saeeda Almarzooqi, Ernest Adeghate, Sandeep B. Subramanya, Shreesh OjhaAntibody,Dilution Ratio,Company and Catalog Number Fibronectin,1:50,Santa Cruz Biotechnology (sc-8422) E-cadherin,1:50,Santa Cruz Biotechnology (sc-52751) α-SMA,1:50,Cell Signaling Technology (14968s) Vimentin,1:50,Cell Signaling Technology

(20) Midkine promotes PDGF-BB-induced proliferation, migration, and glycolysis of airway smooth muscle cells via the PI3K Akt pathwayPhysiological reportsSeptember 1, 2025Xu Y, Li W, Shi J, Guo Y.rabbit polyclonal, Abcam), Collagen I (1:800, ab255809, rabbit monoclonal, Abcam), Fibronectin (1:600, sc‐8422, mouse monoclonal, Santa Cruz), TNF‐α (1:500, sc‐52746, mouse monoclonal, Santa Cruz), IL‐1β (1:400,

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Fibronectin (EP5) Antibody

Fibronectin (EP5) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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Fibronectin (EP5) Antibody from Santa Cruz Biotechnology, Inc.

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