Podocin Polyclonal Antibody bs-6597R from Bioss Inc.

Product Specs
ItemPodocin Polyclonal Antibody
CompanyBioss Inc.
Price $375.00Supplier Page View Company Product Page
Catalog Numberbs-6597R
ImmunogenKLH conjugated peptide, human Podocin
ReactivityHuman, Mouse, Rat, Rat, Human
ClonalityPolyclonal
HostRabbit
TargetPodocin
IsotypeIgG
Molecular Weight42kDa
Quantity100ul, 20uL
ApplicationsWB, FCM, WB, ELISA, FCM, IHC-P, IHC-F, IF(IHC-P), IF(IHC-F), IF(ICC), IHC-P, Others
Format0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol
Conjugate/TagUnconjugated
Concentration1ug/ul
Antibody TypePrimary Antibody
NCBI Gene AliasesSRN1, PDCN
NCBI Full Gene NameNPHS2 stomatin family member, podocin
TissueKidney

Questions and Answers

Can this antibody be used to study podocyte injury in diabetic nephropathy models?

Yes, the Podocin Polyclonal Antibody has been utilized in studies investigating podocyte injury, particularly in diabetic nephropathy models. For instance, in a study examining the effects of rosmarinic acid on podocyte detachment in STZ-induced diabetic rats, the antibody was employed to assess podocin expression through immunofluorescence staining, demonstrating its relevance in this context ().

What species can this antibody react with, and is it suitable for human studies?

The Podocin Polyclonal Antibody is reactive with mouse, rat, and human tissues, making it suitable for studies involving these species, including human research on glomerular diseases. Its application in human studies is supported by its use in characterizing glomerular barrier dysfunction in glomerulonephritis models ().

How has this antibody been applied in immunofluorescence assays?

The Podocin Polyclonal Antibody has been effectively used in immunofluorescence assays to visualize podocin expression in cultured podocytes. In a study, cells were fixed, permeabilized, and then incubated with the antibody to assess podocin levels, highlighting its utility in examining podocyte integrity and function ().

Is there any evidence of this antibody being used in research related to glomerular filtration barrier studies?

Yes, the Podocin Polyclonal Antibody has been cited in research focused on glomerular filtration barrier studies. It was used to evaluate podocyte-specific markers in a microfluidic glomerulus-on-a-chip model, which aims to replicate the physiological environment of the glomerular filtration barrier, thus providing insights into glomerular diseases ().

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(1) MYO1C is a urinary extracellular vesicle biomarker and mediator of podocyte injury in diabetic nephropathyJCI InsightMarch 9, 2026Zihao Zhao, Qianqian Yan, Sijie Zhou, Fengxun Liu, Yong Liu, Jingjing Ren, Shaokang Pan, Zhenjie Liu, Dongwei Liu, Zhangsuo Liu, et al.(ab263019, Abcam), Alix (ab275377, Abcam), TSG 101 (ab125011, Abcam), Calnexin (ab133615, Abcam), NPHS2(BS6597R, Bioss), SYNPO(21064-1-AP, Proteintech), WT-1(sc7385, Santa), TNF-α(A0277, ABclonal), cleaved caspased-3

(2) Hyperoside ameliorates lupus nephritis by suppressing AKT1-mediated PANoptosis in podocytes: integrating network pharmacology and experimental validationFrontiers in PharmacologyJanuary 7, 2026Lili Cheng, Zhongfu Tang, Ming Li, Chuanbing HuangProteintech, USA), nephrin (bs-10233R, Bioss, China), podocalyxin (bs-1345R, Bioss, China), and podocin (bs-6597R, Bioss, China); immunofluorescence (IF) staining was used to detect NLRP3 (DF7438, Affinity, UK), RIPK3

(3) Characterizing Glomerular Barrier Dysfunction with Patient-Derived Serum in Glomerulus-on-a-Chip Models: Unveiling New Insights into GlomerulonephritisInternational Journal of Molecular SciencesMay 8, 2024Shin Young Kim, Yun Yeong Choi, Eun Jeong Kwon, Seungwan Seo, Wan Young Kim, Sung Hyuk Park, Seokwoo Park, Ho Jun Chin, Ki Young Na, Sejoong Kimwith PBS and incubated with primary antibodies for podocin (1:200, Bioss antibodies, Woburn, MA, USA, #bs-6597R), nephrin (1:50, Bioss antibodies, Woburn, MA, USA, #bs-10233R-FITC), and Wilms’ tumor 1 (WT1) (1:100,

(4) DLBS3233 enhances nephrin and podocin expression also reduces oxidative stress marker and insulin receptor serine diabetic rats’ podocytesAnnals of Medicine & SurgeryMarch 14, 2023Chandra Irwanadi Mohani, Achmad Rudijanto, Aulanni’am Aulanni’am, Setyawati SoehartoRT). Podocin expression was assessed using a rabbit antiNPHS2/podocin polyclonal antibody (cat. no. bs-6597R) from BIOSS Inc. The nephrin (G-8) HRP mouse monoclonal IgG2a (cat. no. sc-376522) from Santa Cruz Biotechnology,

(5) cGAS-STING activation contributes to podocyte injury in diabetic kidney diseaseiScienceOctober 21, 2022Zang N, Cui C, Guo X, Song J, Hu H, Yang M, Xu M, Wang L, Hou X, He Q, et al.AB_2070042 Anti-PARP,CST,Cat#9542; RRID: AB_2160739 Anti-Cleaved-PARP,CST,Cat#9548; RRID: AB_2160592 Anti-Podocin,Bioss,Cat#bs-6597R; RRID: AB_11103353 Anti-Nephrin,Bioss,Cat#bs-4866R Anti-Nephrin,Santa Cruz,Cat#sc-377246 Anti-synaptopodin,Protech,Cat#21064-1-AP;

(6) Effect of shenyan xiaobai granule on nephrin and podocin of adriamycin-induced renal injury: A randomised controlled trialJournal of ethnopharmacologyNovember 15, 2019Cao S, Huang W, Yu Z, Yang X, Liu N, Ma T, Tang S, Wang L.

(7) Rosmarinic acid monotherapy is better than the combination of rosmarinic acid and telmisartan in preventing podocyte detachment and inhibiting the progression of diabetic nephropathy in ratsBiologics : targets & therapyJanuary 1, 2019Samsu N, Soeharto S, Rifai M, Rudijanto A.whereas podocin expression was determined by by rabbit anti-NPHS2/Podocin polyclonal antibody (cat. no. bs-6597R) from BIOSS Inc. (Woburn, MA, USA). Animals Adult male Wistar rats (7–9 weeks; 150–170 g) obtained

(8) CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney diseaseThe Journal of clinical investigationAugust 1, 2018Maeda K, Otomo K, Yoshida N, Abu-Asab MS, Ichinose K, Nishino T, Kono M, Ferretti A, Bhargava R, Maruyama S, et al.

(9) GSK-3β inhibitor attenuates urinary albumin excretion in type 2 diabetic db/db mice, and delays epithelial-to-mesenchymal transition in mouse kidneys and podocytesMolecular medicine reportsAugust 1, 2016Wan J, Li P, Liu DW, Chen Y, Mo HZ, Liu BG, Chen WJ, Lu XQ, Guo J, Zhang Q, et al.follows: Rabbit polyclonal anti‑podocin (dilution, 1:1,000; Bioss, Inc., Woburn, MA, USA; cat. no. bs6597R) rabbit polyclonal anti‑nephrin (dilution, 1:1,000; cat. no. ab58968), rabbit polyclonal anti‑synaptopodin

(10) Specific renal parenchymal-derived urinary extracellular vesicles identify age-associated structural changes in living donor kidneysJournal of extracellular vesiclesJanuary 1, 2016Turco AE, Lam W, Rule AD, Denic A, Lieske JC, Miller VM, Larson JJ, Kremers WK, Jayachandran M.

(11) Extracellular vesicles in urine of women with but not without kidney stones manifest patterns similar to men: a case control studyBiology of sex differencesJanuary 1, 2015Jayachandran M, Lugo G, Heiling H, Miller VM, Rule AD, Lieske JC.

(12) Vitamin D prevents podocyte injury via regulation of macrophage M1/M2 phenotype in diabetic nephropathy ratsEndocrinologyDecember 1, 2014Zhang XL, Guo YF, Song ZX, Zhou M.