Bioss Inc.'s SREBP-2 Polyclonal Antibody, Cy5.5 Conjugated is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunofluorescence. The SREBP-2 Polyclonal Antibody, Cy5.5 Conjugated was generated using SREBF2 as the antigen and it reacts with Homo Sapiens, Human, Mouse, and Rat.
Description
Under basal conditions SREBP is bound to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active forms (50-68 kDa) and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol. ab30682 detects both precursor and active forms of SREBP2 in tissues and cells such as liver, brown fat, testis, HepG2 cells, and human fibroblast. The apparent molecular weight on SDS-PAGE may be higher than the calculated molecular weight (about 126 kDa) due to glycosylation of the protein