The Rb/p105-Rb(Ser780) Polyclonal Antibody, Cy5 Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to RB1. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The Rb/p105-Rb(Ser780) Polyclonal Antibody, Cy5 Conjugated has been shown to work in the following applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, Immunohistochemistry - frozen, and Western Blot.
Description
Nuclear Marker.The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma