4E-BP1 (P-1) Antibody sc-9977 from Santa Cruz Biotechnology, Inc.

Product Specs
Item4E-BP1 (P-1) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-9977
Antibody TypePrimary Antibodies
NCBI Gene AliasesPHAS-I, BP-1, 4e-bp1, 4EBP1, 4E-BP1
Quantity200 µg/ml
ApplicationsWB, IP, IF, IHC(P), ELISA
Reactivitymouse, rat, human, porcine
CloneP-1
Conjugate/TagUnconjugated
FormatPurified
ClonalityMonoclonal
Hostmouse
NCBI Full Gene Nameeukaryotic translation initiation factor 4E binding protein 1
Target4E-BP1
IsotypeIgG1

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) MAP Kinase Phosphatase-5 Deficiency Improves Endurance Exercise CapacityCellsMarch 11, 2025Jaime A. Perales, Ahmed Lawan, Sudip Bajpeyi, Sung Min Han, Anton M. Bennett, Kisuk Minpurchased from Cell Signaling Technology (Danvers, MA, USA). p38 MAPK (sc-535), JNK (sc-571), 4E-BP1 (sc-9977), PCNA (cs-13110), and GATA4 (sc-25310) were sourced from Santa Cruz Biotechnology (Dallas, TX, USA).

(2) Inhibition of Retinal Neovascularization by BEZ235: Targeting the Akt/4EBP1/Cyclin D1 Pathway in Endothelial CellsInvest Ophthalmol Vis SciJanuary 31, 2025Qi Liu, Ling-Xiao Xia, Wan-Zhao Yi, Ya-Ni Wu, Shuo-Shuo Gu, Jian-Ying Chen, Ting-Ting Liu, Ying-Hui Lu, Yu-Hong Cui, Jing Meng, et al.D1 (sc-8396), Akt1/2/3 (sc-81434), β-actin (sc-81178), S6K1 (sc-8418), 4E-binding protein 1 (4EBP1; sc-9977), CD31 Alexa Fluor 594 (sc-18916 AF594), and their phosphorylated forms, p-Akt1/2/3 (sc-514032), p-S6K1

(3) Metabolic Heterogeneity in Diffuse Large B-Cell Lymphoma Cells Reveals an Innovative Antimetabolic Combination StrategyCancers (Basel)January 24, 2025Leonardo Lordello, Stéphanie Nuan-Aliman, Karoline Kielbassa-Elkadi, Aurélie Montagne, Konstantina Kotta, Isabelle Martins, Eva Pinto Jurado, Cédric Caradeuc, Jacqueline Lehmann-Che, José Ángel Martínez-Climent, et al.antibodies were purchased from Santa Cruz Biotechnology, Dallas, TX, USA (p70 S6 kinase sc-8418; 4EBP1 sc-9977; p38alpha/beta MAPK sc-7972; ERK1/2 sc-514302; β-actin sc-47798; GAPDH sc-32233), Cell Signaling Technology,

(4) HN1 Functions in Protein Synthesis Regulation via mTOR‐RPS6 Axis and Maintains Nucleolar IntegrityCell ProliferationJanuary 13, 2025Gülseren Özduman, Aadil Javed, Azime Akçaöz Alasar, Bünyamin Akgül, Kemal Sami Korkmaz"Santa Cruz—sc‐293,124","1/500, 1/200" Anti‐4EBP1/2/3,IB,"Santa Cruz—sc‐271,947",1/500 Anti‐4EBP1,IB,Santa Cruz—sc‐9977,1/500 Anti‐p‐GSK3β(S9),IB,"Santa Cruz—sc‐11,757",1/500 Anti‐p‐GSK3β (Tyr 216),IB,"Santa Cruz—sc‐135,653",1/500 Anti‐p‐p70S6K1(S434),"IB,

(5) GRP78 inhibitor YUM70 upregulates 4E-BP1 and suppresses c-MYC expression and viability of oncogenic c-MYC tumorsNeoplasiaSeptember 1, 2024Vicky Yamamoto, Dat P. Ha, Ze Liu, Miller Huang, Soma Samanta, Nouri Neamati, Amy S. Lee(1:1000, Santa Cruz Biotechnology, Inc., sc-9976), mouse 4E-BP1 (1:1000, Santa Cruz Biotechnology, Inc., sc-9977), mouse phospho-4E-BP1 (1:1000, Santa Cruz Biotechnology, Inc., sc-293124), mouse elF5A (1:1000, Santa Cruz Biotechnology, Inc

(6) Inhibition of PRL2 Upregulates PTEN and Attenuates Tumor Growth in Tp53-deficient Sarcoma and Lymphoma Mouse ModelsCancer Res CommunJanuary 2, 2024Nguele Meke F, Bai Y, Ruiz-Avila D, Carlock C, Ayub J, Miao J, Hu Y, Li Q, Zhang ZY.(Santa Cruz Biotechnology, catalog no. sc-20044, RRID: AB_627346), 4E-BP1 (Santa Cruz Biotechnology, catalog no. sc-9977, RRID: AB_626621), p-4E-BP1/2/3 (Santa Cruz Biotechnology, catalog no. sc-271947, RRID:AB_10709575),

(7) USP10 Contributes to Colon Carcinogenesis via mTOR/S6K Mediated HIF-1α but Not HIF-2α Protein SynthesisCellsJune 8, 2023Kubaichuk K, Kietzmann T.mTOR (Santa Cruz, sc-517464, 1:500), p-4E-BP 1/2/3 (Santa Cruz, sc-271947, 1:500), 4E-BP1 (Santa Cruz, sc-9977, 1:500), VEGF (Santa Cruz, sc-152, 1:500), Glut1 (Santa Cruz, sc-377228, 1:500), HIF-1α (BD Bioscience,

(8) The curcumin analogue PAC has potent anti-anaplastic thyroid cancer effectsScientific reportsMarch 14, 2023Al-Mohanna M, Alraouji NN, Alhabardi SA, Al-Mohanna F, Al-Otaibi B, Al-Jammaz I, Aboussekhra A.

(9) Carboxyl-terminal modulator protein (CTMP) deficiency mitigates denervation-induced skeletal muscle atrophyBiochemical and biophysical research communicationsFebruary 12, 2023Wang J, Tierney L, Wilson C, Phillips V, Goldman L, Mumaw C, Muang E, Walker CL.

(10) Intranasal Administration of KYCCSRK Peptide Rescues Brain Insulin Signaling Activation and Reduces Alzheimer's Disease-like Neuropathology in a Mouse Model for Down SyndromeAntioxidants (Basel, Switzerland)January 2, 2023Tramutola A, Lanzillotta S, Aceto G, Pagnotta S, Ruffolo G, Cifelli P, Marini F, Ripoli C, Palma E, Grassi C, et al.Name,Code,Company,Dilution 3-NT,SAB5200009,Sigma-Aldrich,1:1000 4-HNE,NB10063093,Novus,1:2000 4EBP1 (P1),sc-9977,SANTA CRUZ,1:1000 Akt,AM-1011,ECM,1:1000 ADAM10,Ab227172,Abcam,1:1500 APP,A8717,Sigma-Aldrich,"1:10,000" APP-C99,MABN380,Sigma-Aldrich,1:1000 ATG5,sc-133158,SANTA CRUZ

(11) Targeting GRP78 suppresses oncogenic KRAS protein expression and reduces viability of cancer cells bearing various KRAS mutationsNeoplasia (New York, N.Y.)November 1, 2022Ha DP, Huang B, Wang H, Rangel DF, Van Krieken R, Liu Z, Samanta S, Neamati N, Lee AS.Santa Cruz Biotechnology, Inc., sc-9976), mouse anti-4E-BP1 (P1) (1:1000, Santa Cruz Biotechnology, Inc., sc-9977), mouse anti-phospho-4E-BP1 (62.Ser 65) (1:1000, Santa Cruz Biotechnology, Inc., sc-293124), rabbit

(12) Mitochondria-targeted anti-oxidant AntiOxCIN(4) improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systemsRedox biologySeptember 1, 2022Amorim R, Simões ICM, Teixeira J, Cagide F, Potes Y, Soares P, Carvalho A, Tavares LC, Benfeito S, Pereira SP, et al.mice groups. Then we perform Western blotting with antibodies against the denatured form of 4E-BP1 (sc9977, Santa Cruz Biotechnology), AKT (#4691, Cell Signaling), LC3 (#12741, Cell Signaling,USA), mTOR (#2972,

(13) Cryptolepine suppresses breast adenocarcinoma via inhibition of HIF-1 mediated glycolysisBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapieSeptember 1, 2022Zheng Z, Xu T, Liu Z, Tian W, Jiang ZH, Zhu GY, Li T, Gao J, Bai LP.

(14) Glutamate-aspartate transporter 1 attenuates oxygen-glucose deprivation-induced injury by promoting glutamate metabolism in primary cortical neuronsJournal of cellular physiologyJuly 1, 2022Zhao YZ, Wei J, Song KX, Zhou C, Chai Z.

(15) Calcium fructoborate regulate colon cancer (Caco-2) cytotoxicity through modulation of apoptosisJournal of biochemical and molecular toxicologyMay 1, 2022Kisacam MA, Ambarcioglu P, Yakan A.

(16) Acute Manganese Exposure Modifies the Translation Machinery via PI3K/Akt Signaling in Glial CellsASN neuroJanuary 1, 2022Soto-Verdugo J, Siva-Parra J, Hernández-Kelly LC, Ortega A.(Cat# sc-81434, RRID:AB_1118808), anti-p4E-BP1 (Cat# sc-23768-R, RRID: AB_2095599), anti-4E-BP1 (Cat# sc-9977, RRID:AB_626621) were purchased from Santa Cruz Biotechnology (Dallas, TX, USA); anti-pAMPK (Cat# 2535,

(17) Hormetic effect of low doses of rapamycin triggers anti-aging cascades in WRL-68 cells by modulating an mTOR-mitochondria cross-talkMolecular biology reportsJanuary 1, 2022Mahalakshmi R, Priyanga J, Bhakta-Guha D, Guha G.

(18) The female syndecan-4(-/-) heart has smaller cardiomyocytes, augmented insulin/pSer473-Akt/pSer9-GSK-3β signaling, and lowered SCOP, pThr308-Akt/Akt and GLUT4 levelsFrontiers in cell and developmental biologyJanuary 1, 2022Støle TP, Lunde M, Shen X, Martinsen M, Lunde PK, Li J, Lockwood F, Sjaastad I, Louch WE, Aronsen JM, et al.United States) anti-pThr70-4E-BP1 (1:1000, 5% BSA, #9455, Cell Signaling), anti-4E-BP1 (1:500, 5% BSA, sc-9977, Santa Cruz), anti-c-SRC (1:250, 1 × casein, sc-8056, Santa Cruz), anti-integrin-β1 (1:1000, 5% milk,

(19) UCH-L1 and UCH-L3 regulate the cancer stem cell-like properties through PI3 K/Akt signaling pathway in prostate cancer cellsAnimal cells and systemsJanuary 1, 2021Lee JE, Lim YH, Kim JH.follows. OCT4 (sc-9081), BMI1 (sc-390443), SOX2 (sc-17320), Nanog (sc-134218), AKT (sc-8312), 4EBP1 (sc-9977), p70 S6 kinase (sc-8418), and UCH-L1 (sc-58593) were purchased from Santa Cruz. KLF4 (ab151733), phospho-AKT

(20) Ascofuranone inhibits epidermal growth factor-induced cell migration by blocking epithelial-mesenchymal transition in lung cancer cellsEuropean journal of pharmacologyAugust 5, 2020Kim HW, Jeong YJ, Hwang SK, Park YY, Choi YH, Kim CH, Magae J, Chang YC.

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4E-BP1 (P-1) Antibody

4E-BP1 (P-1) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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4E-BP1 (P-1) Antibody from Santa Cruz Biotechnology, Inc.

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