Beclin 1 (E-8) Antibody from Santa Cruz Biotechnology, Inc.

The Beclin 1 (E-8) antibody is reactive with mouse, human (Homo sapiens), and rat species, making it suitable for a variety of biological studies across these organisms.

Yes, the Beclin 1 antibody has been shown to work in several applications, including Western blotting, immunofluorescence, and immunohistochemistry, as evidenced by its use in studies such as those investigating the interaction between Beclin 1 and Na+,K+-ATPase during stress conditions (fernande2020).

In studies utilizing the Beclin 1 antibody, it was found that Beclin 1 interacts with Na+,K+-ATPase during stress conditions, which plays a role in autophagy and cell death mechanisms. For instance, starvation increased this interaction in cultured cells, and cardiac glycosides were shown to block this interaction, highlighting the antibody's relevance in autophagy research (fernande2020).

The Beclin 1 antibody has been utilized in research to elucidate the role of autophagy in various diseases, such as in the context of silicosis where autophagy was linked to macrophage activation and apoptosis. The antibody's application in these studies helps clarify the mechanisms by which autophagy contributes to disease progression (liu2017).