Ref-1 (C-4) Antibody sc-17774 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemRef-1 (C-4) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-17774
NCBI Gene AliasesAPE1, APX, Ref-1, APEX, Apex, REF1, HAP1, APEN, APE
Antibody TypePrimary Antibodies
Quantity200 µg/ml
CloneC-4
ApplicationsWB, IP, IF, IHC(P)
Reactivitymouse, rat, human
FormatPurified
Hostmouse
Conjugate/TagUnconjugated
ClonalityMonoclonal
NCBI Full Gene Nameapurinic/apyrimidinic endodeoxyribonuclease 1, apurinic/apyrimidinic endonuclease 1
TargetRef-1
IsotypeIgG2b

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Proinflammatory macrophage secretome enhances temozolomide sensitivity in glioblastoma via pSTAT3-mediated downregulation of DNA repair enzymesScientific ReportsNovember 6, 2025Susana López-López, Beatriz Castro-Robles, Natalia García-Flores, María José M. Díaz-Guerra, Lourdes Arias-Salazar, Hernán Sandoval, Daniel García-Pérez, Christoph J. Klein-Zampaña, Rosa A. Barbella-Aponte, Tomás Segura, et al.and anti-STAT1 (9172 S) from Cell Signaling, anti-MPG (sc-101237), anti-MSH2 (sc-376384), anti-APE1 (sc-17774), anti-PARP-1 (sc-8007), anti-BLC2 (sc-7382), anti-caspase-3 (sc-56053) and anti-β-ACTIN (sc-81178)

(2) RECQ5 mediates pre-rRNA processing in nucleolusNucleic acids researchAugust 11, 2025Ma Y, Yu X.(Ser345) (CST, Rabbit, 2348), anti-TOPBP1 (Santa Cruz, Mouse, sc-271043), anti-APE1 (Santa Cruz, Mouse, sc-17774), VE-821(MCE, HY-14731), RECQ5-IN-1(RECQ5 inhibitor, MCE, HY-145685), BMH-21 (Selleck, S7718), ATP-γ-S

(3) Apex1 safeguards genomic stability to ensure a cytopathic T cell fate in autoimmune disease modelsThe Journal of clinical investigationDecember 31, 2024Xiao X, Du Y, Sun S, Su X, Xing J, Wang G, Elzein SM, Zou D, Minze LJ, Mao Z, et al.by SDS-PAGE, transferred onto an Immobilon membrane, and analyzed by immunoblotting with anti-Apex1 (sc-17774, 1:800, Santa Cruz Biotechnology) and anti–β-actin (12262, 1:2000, Cell Signaling Technology). Horseradish

(4) Predictive and Prognostic Value of TUBB3, RRM1, APE1, and Survivin Expression in Chemotherapy-Receiving Patients with Advanced Non‑Small Cell Lung CancerAsian Pacific Journal of Cancer PreventionSeptember 1, 2023Pritsana Raungrut, Suchanan Tanyapattrapong, Jirapon Jirapongsak, Sarayut Lucien Geater, Paramee ThongsuksaiRRM1 (A-10, mouse monoclonal antibody sc-377415, dilution 1:500), APE1 (C-4, mouse monoclonal antibody sc-17774, dilution 1:10,000), and survivin (D-8, mouse monoclonal antibody sc-17779, dilution 1:100). All antibodies

(5) APE1 recruits ATRIP to ssDNA in an RPA-dependent and -independent manner to promote the ATR DNA damage responseeLifeMay 22, 2023Lin Y, Li J, Zhao H, McMahon A, McGhee K, Yan S.,Santa Cruz Biotechnology,Cat#sc-8036,IB (1:1000) Antibody,Anti-human APE1 (Mouse monoclonal),Santa Cruz Biotechnology,Cat#sc-17774,IB (1:2000) Antibody,Anti-PCNA (Mouse monoclonal),Santa Cruz Biotechnology,Cat#sc-56,IB (1:4000)

(6) HSPs/STAT3 Interplay Sustains DDR and Promotes Cytokine Release by Primary Effusion Lymphoma CellsInternational journal of molecular sciencesFebruary 15, 2023Gonnella R, Arena A, Zarrella R, Gilardini Montani MS, Santarelli R, Cirone M.sc-482), mouse monoclonal anti-APE (Ref-1) (1:500) (Santa Cruz Biotechnology Inc, Dallas, TX, USA, cat n. sc-17774), mouse monoclonal anti-ATM (1:200) (Santa Cruz Biotechnology Inc, Dallas, TX, USA, cat n. sc-135663),

(7) APE1 assembles biomolecular condensates to promote the ATR-Chk1 DNA damage response in nucleolusNucleic acids researchOctober 14, 2022Li J, Zhao H, McMahon A, Yan S.(27–29,60,64). Primary antibodies were purchased from respective vendors: APE1 (Santa Cruz Biotechnology Cat#sc-17774), ATR (Santa Cruz Biotechnology Cat#515173), ATM (GeneTex Cat#GTX70103), ATM phosphorylation at Ser1981

(8) DNA damage through oxidative stress is an important event in oral leukoplakiaArchives of oral biologyMarch 1, 2022Barros CCDS, Freitas RA, Miguel MCDC, Dantas da Silveira ÉJ.

(9) Active demethylation upregulates CD147 expression promoting non-small cell lung cancer invasion and metastasisOncogeneMarch 1, 2022Liao CG, Liang XH, Ke Y, Yao L, Liu M, Liu ZK, He L, Guo YX, Bian H, Chen ZN, et al.used are shown in Supplementary Table 4. AID, APE-1, DNA Ligase, and DNA pol β antibodies (sc-14680, sc-17774, sc-47703, and sc-48810, respectively) were purchased from Santa Cruz Biotechnology. Co-immunoprecipitation (co-IP

(10) Mitotic Activation Around Wound Edges and Epithelialization Repair in UVB-Induced Capsular CataractsInvestigative ophthalmology & visual scienceDecember 1, 2021Wei Z, Hao C, Srinivasagan R, Wu H, Chen JK, Fan X.purchased from Cell Signaling Technology (Danvers, MA, USA). Apurinic/apyrimidinic endonuclease 1 (APE1; Sc-17774) used for immunofluorescence staining and APE1 (Sc-55498) used for immunoblot were purchased from Santa Cruz Biotechnology

(11) Chlorine, chromium, proteins of oxidative stress and DNA repair pathways are related to prognosis in oral cancerScientific reportsNovember 16, 2021de Assis ALEM, Archanjo AB, Maranhão RC, Mendes SO, de Souza RP, de Cicco R, de Oliveira MM, Borçoi AR, de L Maia L, Nunes FD, et al.with Antibody Diluent (Catalog no. ADS-125, Spring Bioscience, Canada), anti-Ref-1 was diluted 1:400 (SC-17774, Santa Cruz), anti-OGG1/2 was diluted 1:100 (SC-376935, Santa Cruz Biotechnology) and anti-Trx was diluted

(12) APE1 may influence CD4+ naïve T cells on recurrence free survival in early stage NSCLCBMC cancerMarch 6, 2021Li Y, Zhao X, Xiao H, Yang B, Liu J, Rao W, Dai X, Li M, Dai N, Yang Y, et al.The sections were then washed in PBS and incubated overnight at 4 °C with a primary antibody: APE1 (SC-17774, Santa Cruz Biotechnology Inc.), CD4 (ZA-0519, ZSGB-BIO). After washing with PBS, the sections were

(13) ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cellsNature cell biologyFebruary 1, 2021Verma P, Zhou Y, Cao Z, Deraska PV, Deb M, Arai E, Li W, Shao Y, Puentes L, Li Y, et al.

(14) Chemical Inhibition of Apurinic-Apyrimidinic Endonuclease 1 Redox and DNA Repair Functions Affects the Inflammatory Response via Different but Overlapping MechanismsFrontiers in cell and developmental biologyJanuary 1, 2021Oliveira TT, Fontes-Dantas FL, de Medeiros Oliveira RK, Pinheiro DML, Coutinho LG, da Silva VL, de Souza SJ, Agnez-Lima LF.Scientific Ltd.). Further, DNA protein complexes were immunoprecipitated with ChIP quality Abs (APE1/Ref-1, sc-17774, Santa Cruz Biotechnology) using the Chromatin Immunoprecipitation Assay kit (Merck Millipore). The

(15) XPA deficiency affects the ubiquitin-proteasome system functionDNA repairOctober 1, 2020de Sousa Leal AM, de Azevedo Medeiros LB, Muñoz-Cadavid CO, de Paula Oliveira R, de Souza Timóteo AR, de Oliveira AHS, Luis Fonseca Faustino A, da Silva VL, de Souza SJ, Braz Petta Lajus T, et al.

(16) Mitochondrial APE1 promotes cisplatin resistance by downregulating ROS in osteosarcomaOncology reportsAugust 1, 2020Liu Y, Zhang Z, Li Q, Zhang L, Cheng Y, Zhong Z.

(17) APE1 Promotes Pancreatic Cancer Proliferation through GFRα1/Src/ERK Axis-Cascade Signaling in Response to GDNFInternational journal of molecular sciencesMay 19, 2020Choi YD, Jung JY, Baek M, Khan S, Song PI, Ryu S, Koo JY, Chauhan SC, Tsin A, Choi C, et al.

(18) Clinical Significance of Jagged-1 Activated by APEX1 as a Chemoresistance Factor in Advanced Gastric CancerAnticancer researchApril 1, 2020Kim HB, Lee HJ, Kim GB, Lim HJ, Park JH, Park SG.

(19) APEX1 is a novel diagnostic and prognostic biomarker for hepatocellular carcinomaAgingMarch 13, 2020Cao L, Cheng H, Jiang Q, Li H, Wu Z.(http://www. proteinatlas.org) database [48]. Immunohistochemical staining was performed using the anti-APEX1 antibody (Cat. No. sc-17774; Santa Cruz, USA). Gene set enrichment analysis (GSEA) Real-time quantitative PCR (qPCR) We performed

(20) Immunoexpression of DNA base excision repair and nucleotide excision repair proteins in ameloblastomas, syndromic and non-syndromic odontogenic keratocysts and dentigerous cystsArchives of oral biologyFebruary 1, 2020Santos HBP, Morais EF, Cavalcante RB, Nogueira RLM, Nonaka CFW, Souza LB, Freitas RA.

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Ref-1 (C-4) Antibody

Ref-1 (C-4) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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Ref-1 (C-4) Antibody from Santa Cruz Biotechnology, Inc.

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