The Bcr Polyclonal Antibody, PE-Cy5 Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to BCR, and BCR activator of RhoGEF and GTPase. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The Bcr Polyclonal Antibody, PE-Cy5 Conjugated has been shown to work in the following applications: Flow Cytometry.
Description
The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling