Bioss Inc.'s ASIC1/BNaC2/ASIC1A Polyclonal Antibody, PE Conjugated is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The ASIC1/BNaC2/ASIC1A Polyclonal Antibody, PE Conjugated was generated using ASIC1 as the antigen and it reacts with Homo Sapiens, Human, Mouse, and Rat.
Description
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear