POL H (B-7) Antibody sc-17770 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemPOL H (B-7) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-17770
Quantity200 µg/ml
ApplicationsWB, IP, IF, IHC(P), ELISA
Reactivityhuman
Conjugate/TagUnconjugated
FormatPurified
Antibody TypePrimary Antibodies
CloneB-7
Hostmouse
TargetPOL H
IsotypeIgG1
NCBI Gene AliasesXP-V, RAD30, XPV, RAD30A
ClonalityMonoclonal
NCBI Full Gene NameDNA polymerase eta

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Translesion-synthesis-mediated bypass of DNA lesions occurs predominantly behind replication forks restarted by PrimPolCell reportsMarch 25, 2025Dhoonmoon A, Ambrose JR, Garg S, Lascarez-Espana C, Rebok A, Spratt TE, Moldovan GL, Nicolae CM.Bethyl Laboratories A150–109A); Polκ (Santa Cruz Biotechnology sc-166667), Polη (Santa Cruz Biotechnology sc-17770), Ubiquityl-PCNA Lys164 (Cell Signaling Technology 13439); REV1 (Santa Cruz Biotechnology sc-393022),

(2) Chromatin assembly factor 1 subunit A promotes TLS pathway by recruiting E3 ubiquitin ligase RAD18 in cancer cellsCell Death DisMarch 1, 2025Bing Wen, Hai-Xiang Zheng, Jing-Hua Heng, Qian Tang, Dan-Xia Deng, Zhi-Da Zhang, Lian-Di Liao, Li-Yan Xu, En-Min Limouse monoclonal anti-REV1 (sc-393022, Santa Cruz Biotechnology; 1:1000), mouse monoclonal anti-Pol η (sc-17770, Santa Cruz Biotechnology; 1:1000), mouse monoclonal anti-His Antibody (HT501, TransGen Biotech; 1:5000),

(3) HPV 16 E7 alters translesion synthesis signalingVirology journalOctober 20, 2022Wendel SO, Stoltz A, Xu X, Snow JA, Wallace N.TopBP1 (Santa Cruz Biotechnology, catalog no. sc-271043), POLη (Santa Cruz Biotechnology, catalog no., sc-17770), GAPDH (Santa Cruz Biotechnology, catalog no. sc-47724), Nucleolin (Santa Cruz Biotechnology, catalog

(4) Changes in the architecture and abundance of replication intermediates delineate the chronology of DNA damage tolerance pathways at UV-stalled replication forks in human cellsNucleic acids researchSeptember 23, 2022Benureau Y, Pouvelle C, Dupaigne P, Baconnais S, Moreira Tavares E, Mazón G, Despras E, Le Cam E, Kannouche PL.#A301-975A), rabbit anti-polη (Abcam #ab17725, Bethyl #A301-231A), mouse anti-polη (B-7, Santa Cruz #sc-17770), rabbit anti-PrimPol (kind gift from L. Blanco), rabbit anti-RAD51 (Calbiochem #PC130-100UL), mouse

(5) DNA polymerase η is a substrate for calpain: a possible mechanism for pol η retention in UV-induced replication fociJournal of cell scienceJuly 1, 2021Nettersheim JA, Janel-Bintz R, Kuhn L, Cordonnier AM.proximity ligation assay (PLA) between pol η and CAPNS1 was performed using the mouse anti-pol η (B7; sc-17770; Santa Cruz Biotechnology; 1:100), the rabbit antiCAPNS1 (HPA006872; Sigma-Aldrich; 1:3000) and the

(6) Age and insulin-like growth factor-1 impact PCNA monoubiquitination in UVB-irradiated human skinThe Journal of biological chemistryJanuary 1, 2021Hutcherson RJ, Gabbard RD, Castellanos AJ, Travers JB, Kemp MG.against ubiquityl-PCNA (Lys 164; Cell Signaling #13439), PCNA (Santa Cruz sc-56), Pol eta (Santa Cruz sc-17770), Pol iota (GeneTex GTX112137), and Rev1 (Santa Cruz sc-393022). After washing, the blots were probed

(7) DNA polymerase ι compensates for Fanconi anemia pathway deficiency by countering DNA replication stressProceedings of the National Academy of Sciences of the United States of AmericaDecember 29, 2020Wang R, Lenoir WF, Wang C, Su D, McLaughlin M, Hu Q, Shen X, Tian Y, Klages-Mundt N, Lynn E, et al.ABclonal), CDK4 (12790; Cell Signaling Technology), Pol κ (A301-977A; Bethyl Laboratories), Pol η (sc-17770; Santa Cruz Biotechnology), phosphor-ATR (GTX128145; GeneTex), phosphor-ATM (ab81292; Abcam), SMC1 (A300-055A;

(8) High Risk α-HPV E6 Impairs Translesion Synthesis by Blocking POLη InductionCancersDecember 23, 2020Wendel SO, Snow JA, Bastian T, Brown L, Hernandez C, Burghardt E, Kahn A, Murthy V, Neill D, Smith ZC, et al.(Calbiochem, OP43100UG), PCNA (Cell Signaling Technologies 2586S), POLη (Santa Cruz Biotechnologies sc-17770), POLκ (Abcam ab57070), Rad18 (abcam ab57447), Rad6 (abcam ab31917), RPA70 (Cell Signaling Technologies

(9) Insulin-like Growth Factor-1 Impacts p53 Target Gene Induction in UVB-irradiated Keratinocytes and Human SkinPhotochemistry and photobiologyNovember 1, 2020Alkawar AMM, Castellanos AJ, Carpenter MA, Hutcherson RJ, Madkhali MAO, Johnson RM, Bottomley M, Kemp MG.probed with 1:2000 or 1:5000 dilutions of antibodies against actin (Bethyl A300-485), pol η (Santa Cruz sc-17770 or Bethyl A301-231), XPC (Santa Cruz sc-74410), p21 (Santa Cruz sc-2646), sc-DDB2 (Cell Signaling 5416)

(10) β-HPV 8E6 Attenuates ATM and ATR Signaling in Response to UV DamagePathogens (Basel, Switzerland)November 26, 2019Snow JA, Murthy V, Dacus D, Hu C, Wallace NA.(D5C7P) (13439S, Cell Signaling), PCNA (PC10) (2586S, Cell Signaling), POLκ (ab57070, Abcam), POLη (B-7) (sc-17770, Santa Cruz, Dallas, TX), pRPA32/RPA2 (Ser8) (83745S, Cell Signaling), RPA32/RPA2 (52448S, Cell Signaling),

(11) DNA Polymerase Eta Prevents Tumor Cell-Cycle Arrest and Cell Death during Recovery from Replication StressCancer researchDecember 1, 2018Barnes RP, Tsao WC, Moldovan GL, Eckert KA.

(12) Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recoveryeLifeNovember 13, 2018Tonzi P, Yin Y, Lee CWT, Rothenberg E, Huang TT.(1:200) Antibody,Mouse anti-POLK,Santa Cruz,Cat. #: sc-166667,WB (1:1000) Antibody,Mouse anti-POLH,Santa Cruz,Cat. #: sc-17770,WB (1:1000) Antibody,Rabbit anti-POLI,Bethyl,Cat. #: A301-304A,WB (1:5000) Antibody,Rabbit anti-MCM2,Bethyl,Cat.

(13) Polη, a Y-family translesion synthesis polymerase, promotes cellular tolerance of Myc-induced replication stressJournal of cell scienceJune 25, 2018Kurashima K, Sekimoto T, Oda T, Kawabata T, Hanaoka F, Yamashita T.

(14) A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor CellsBiochemistryFebruary 20, 2018Zafar MK, Maddukuri L, Ketkar A, Penthala NR, Reed MR, Eddy S, Crooks PA, Eoff RL.probing the membranes with the following antibodies: anti-hpol η antibody (Santa Cruz; catalog no. sc-17770) and anti-phosphorylated-histone H2AX (S139; Abcam catalog no. ab81299). Dilution of the primary antibody

(15) Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cellsNucleic acids researchFebruary 17, 2017Lerner LK, Francisco G, Soltys DT, Rocha CR, Quinet A, Vessoni AT, Castro LP, David TI, Bustos SO, Strauss BE, et al.were performed as previously described (30). The antibodies that were used were mouse anti-POLH (B-7 sc-17770, Santa Cruz, Dallas, TX, USA) or rabbit anti-POLH (A301-231A, Bethyl, Montgomery, TX, USA), rabbit anti-p21 (C-19

(16) Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNANature communicationsNovember 4, 2016Despras E, Sittewelle M, Pouvelle C, Delrieu N, Cordonnier AM, Kannouche PL.(rabbit, Abcam #ab17725, 1/1,000; rabbit H-300, Santa Cruz #sc-5592, 1/2,000; mouse B-7, Santa Cruz #sc-17770, 1/500; rabbit, Bethyl #A301-231A, 1/1,000), Rad18 (mouse, Abcam #ab57447; rabbit, Bethyl #A301-340A,

(17) Both high-fidelity replicative and low-fidelity Y-family polymerases are involved in DNA rereplicationMolecular and cellular biologyFebruary 1, 2015Sekimoto T, Oda T, Kurashima K, Hanaoka F, Yamashita T.instructions (Invitrogen). Antibodies. The antibodies used in this study were as follows: mouse monoclonal anti-Pol ␩ (sc-17770; Santa Cruz Biotechnology), rabbit polyclonal anti-Pol ␩ (sc-5592; Santa Cruz Biotechnology), rabbit

(18) Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosminNature communicationsNovember 25, 2014Ziv O, Zeisel A, Mirlas-Neisberg N, Swain U, Nevo R, Ben-Chetrit N, Martelli MP, Rossi R, Schiesser S, Canman CE, et al.

(19) Three school-age cases of xeroderma pigmentosum variant typePhotodermatology, photoimmunology & photomedicineJune 1, 2013Ono R, Masaki T, Takeuchi S, Shimizu A, Tanioka M, Kambe N, Matsue H, Kamide R, Nishigori C.

(20) DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicityNucleic acids researchJanuary 1, 2012Diamant N, Hendel A, Vered I, Carell T, Reissner T, de Wind N, Geacinov N, Livneh Z.described (8,22). Sources of antibodies were as follows: mouse monoclonal anti-polη antibody (B-7): sc-17770 (used at a dilution of 1:200 in western blot, Santa Cruz Biotechnology); rabbit polyclonal anti-pol

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POL H (B-7) Antibody

POL H (B-7) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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POL H (B-7) Antibody from Santa Cruz Biotechnology, Inc.

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