Bcl-2 (C-2) Antibody sc-7382 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemBcl-2 (C-2) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-7382
Antibody TypePrimary Antibodies
NCBI Gene AliasesC430015F12Rik, D830018M01Rik, Bcl-2, PPP1R50, D630044D05Rik
ApplicationsWB, IP, IF, IHC(P), FCM
Reactivitymouse, rat, human
Quantity200 µg/ml
CloneC-2
Hostmouse
FormatPurified
ClonalityMonoclonal
Conjugate/TagUnconjugated
NCBI Full Gene NameBCL2 apoptosis regulator, B cell leukemia/lymphoma 2
TargetBcl-2
IsotypeIgG1

Questions and Answers

What applications has the Bcl-2 (C-2) antibody been used for in scientific research?

The Bcl-2 (C-2) antibody has been shown to work in various applications including Western Blotting, Flow Cytometry, Immunofluorescence, Immunohistochemistry, and Immunoprecipitation, as evidenced by its use in multiple studies (, ).

Can this antibody be used to study apoptosis in cancer cells?

Yes, the Bcl-2 (C-2) antibody is relevant for studying apoptosis, particularly in cancer cells. It has been utilized in research examining the balance of pro-apoptotic and pro-survival proteins, which are critical in determining cell fate during apoptosis ().

Is the Bcl-2 (C-2) antibody effective in different species?

The Bcl-2 (C-2) antibody is reactive with multiple species, including humans, mice, and rats, making it versatile for comparative studies across different model organisms ().

How has the Bcl-2 (C-2) antibody been utilized in the context of cancer treatment research?

The Bcl-2 (C-2) antibody has been employed in studies investigating the effects of various treatments on apoptosis in cancer cells, such as the modulation of caspase activity and the impact of chemotherapeutic agents on Bcl-2 expression levels (, ).

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) QW-5-70 targets the colchicine site and demonstrates antitumor activity in P-gp-overexpressing cancer modelsMol Cancer TherApril 22, 2026Yang Xie, Ruida Hou, Najah Albadari, Hao Chen, Darcie J. Miller, Judith Quadrozzi Quadrozzi Gruntz, Michael L. Oldham, Mir Shahriar Kamal, Jianxiong Jiang, Zhongzhi Wu, et al.conjugate (CST, #3683, RRID: AB_1642205), CDK1 (Proteintech, #19532, RRID: AB_2934935), Bcl-2 (Santa Cruz, #sc-7382, RRID: AB_626736) antibodies. Membranes were washed with PBS and incubated with HRP-conjugated secondary

(2) Targeting the ROS-JNK/p38 Axis: Schisandrin A as a Novel Therapeutic Candidate for Esophageal Squamous Cell CarcinomaJ Microbiol BiotechnolApril 17, 2026Minjun Lee, Sang Hoon Joo, Yung Hyun Choi, Goo Yoon, Jin Woo Park, Jung-Hyun ShimBiosesang (Republic of Korea). Primary antibodies against Mcl-1 (sc-12756), Bcl-xL (sc-8392), Bcl-2 (sc-7382), BID (sc-56025), Bad (sc-8044), Apaf-1 (sc-33870), caspase-3 (sc-7148), cyclin D1 (sc-20044), Cdk4

(3) Consumption of Cashew Nuts on Oxidative Stress and Neuroinflammation Markers in Methionine-Induced Hyperhomocysteinemia in RatsFood Sci NutrApril 9, 2026Rosalba Siracusa, Alessia Arangia, Regina Aparo, Marika Cordaro, Roberta Fusco, Giuseppina Mandalari, Salvatore Cuzzocrea, Daniela Impellizzeri, Rosanna Di Paola, Ramona D'Amico(sc‐365949, Santa Cruz Biotechnology (SCB); 1:500), anti‐HO‐1 (sc‐136,960, SCB; 1:500), anti‐Bcl‐2 (sc‐7382, SCB; 1:500), anti‐Bax (sc‐7480, SCB; 1:500), in phosphate‐buffered saline at 4°C overnight. As controls,

(4) Protective Effect of Silymarin Against Paclitaxel-Induced CardiotoxicityFood Sci NutrApril 2, 2026Tuğçe Tutar, Seda Yakut, Adem Kara, Aykut Ulucan, Cüneyt Çağlayanfor 90 min. Primary antibodies (IL‐1β [sc‐52,012], TNF‐α [sc‐52,746], Caspase‐3 [sc‐56,053], Bcl‐2 [sc‐7382], NF‐κB‐p65 [sc‐109], and beta‐actin [sc‐47,778], Santa Cruz Biotechnology, USA; P2X7R [11144–1‐AP],

(5) Endogenous promoter G-quadruplexes scaffold apurinic/apyrimidinic endonuclease (APE1) to drive gene expressionNucleic Acids ResApril 2, 2026Yingling Chen, Bhopal Mohapatra, Suravi Pramanik, Mason Tarpley, Achyuth Kalluchi, Sutapa Ray, Kyle Hewitt, M Jordan Rowley, Vimla Band, Kishor K Bhakatincluded anti-G4 (Sigma, Cat# MABE1126), anti-APE1 [35], and anti-Bcl-2 (Santa Cruz Biotechnology, Cat# sc-7382). Images were captured using a Zeiss confocal microscope and processed with ZEN 2.3 SP1 software. Chromatin immunoprecipitation

(6) Targeting ST18-mediated pathomechanism in pemphigus vulgaris through voltage-dependent anion channel inhibitionSkin Health and DiseaseMarch 31, 2026Sari Assaf, Ofer Sarig, Rawaa Ishtewy, Yazeed Zoabi, Yarden Feller, Kiril Malovitski, Janan Mohamad, Shir Bergson, Carmel Bilu, Varda Shoshan-Barmatz, et al.antibody [diluted 1:200; ab15895 (Abcam)] or mouse monoclonal anti-Bcl-2 Antibody (C-2) [diluted 1:50 (sc-7382; Santa Cruz Biotechnology, Santa Cruz, CA, USA)]. Secondary antibody staining was carried out for 1

(7) PROTAC-Mediated Targeted Degradation of MDM2 Induces Tumor-Suppressive Signaling in Osteosarcoma CellsCellsMarch 5, 2026Yeongji Kim, Jin-Woo Kim, Junwon Choi, Jinhyeong Kim, Soyeon Park, Wonji Choi, Hyunju An, Jinman Kim, Minsup Kim, Sujin Choi, et al.p-AKT (cat. no. sc-293125), BAX (cat. no. sc-23959), β-actin (cat. no. sc-47778), and BCL-2 (cat. no. sc-7382) were acquired from Santa Cruz Biotechnology Inc. (Dallas, TX, USA) Additionally, the antibody against

(8) Antidepressant and Cognitive-Enhancing Effects of Stewartia pseudocamellia Maxim. Leaves in Chronic Unpredictable Mild Stress-Induced Mice Through HPA Axis Regulation and the BDNF/TrkB PathwayPharmaceuticals (Basel)February 25, 2026Yu Mi Heo, Hyo Lim Lee, Hye Ji Choi, Yeong Hyeon Ju, Hwa Rang Na, Ho Jin HeoUSA)",ACTH,sc-57018 "Santa Cruz Biotech (Dallas, TX, USA)",β-actin,sc-69879 "Santa Cruz Biotech (Dallas, TX, USA)",BCl-2,sc-7382 "Santa Cruz Biotech (Dallas, TX, USA)",BAX,sc-7480 "Santa Cruz Biotech (Dallas, TX, USA)",Caspase-1,sc-392736 "Santa Cruz

(9) Modulation of Wnt/β-Catenin Pathway by Aesculus hippocastanum Extract Enhances Temozolomide Sensitivity in Glioblastoma CellsJ Cell Mol MedFebruary 16, 2026Sarah Adriana Scuderi, Alessio Ardizzone, Deborah Mannino, Nicoletta Palermo, Fabiola De Luca, Antonio Catalfamo, Michela Campolo, Emanuela Esposito, Irene PaternitiInvitrogen, Waltham, USA, Cat. No. 36‐5800), Bcl‐2 (1:500, Santa Cruz Biotechnology, Dallas, TX, USA; sc‐7382), p53 (1:500, Santa Cruz Biotechnology, Dallas, TX, USA; sc‐126), and Bax (1:1000, Invitrogen, Cat.

(10) Insights into the olaparib-mediated cell death mechanisms in canine hematological malignancies: a different fate for CLBL-1 and GL-1 cell linesFrontiers in Veterinary ScienceFebruary 6, 2026Greta Mucignat, Ewa Dejnaka, Marianna Pauletto, Rosa Maria Lopparelli, Mery Giantin, Aleksandra Pawlak, Mauro Dacastoprimary antibody (54H6, 2764) was obtained from Cell Signaling Technology (Danvers, MA, USA), anti-Bcl-2 (sc-7382), and anti-β-actin clone C4 (sc-47778) antibodies from Santa Cruz Biotechnology (Santa Cruz, CA, USA).

(11) Lupeol restores dopaminergic function by suppressing glial activation in a Parkinson's disease mouse modelFront ImmunolFebruary 2, 2026Riaz Ahmad, Kyonghwan Choe, Hyun Young Park, Waqas Ahmad, Tae Ju Park, Myeong Ok Kim"Santa Cruz Biotechnology, United States",SC23959,1:1000 Bcl-2,Mouse,WB,"Santa Cruz Biotechnology, United States",SC7382,1:1000 Cyto-C,Mouse,WB,"Santa Cruz Biotechnology, United States",SC13156,1:1000 Casp-3,Rabbit,WB/IF,Cell Signaling

(12) The novel IDO-1 inhibitor 3-047 combined with icaritin ameliorates neuroinflammation and diabetes-associated cognitive dysfunction with suppression of TLR4/MyD88/NF-κB signalingFrontiers in ImmunologyJanuary 26, 2026Tingmei Mo, Xia Zhuang, Wenxue Zhao, Baohua Wang, Yuting Wang, Wenjie Ji, Dongguang Liu, Guimin Zhang, Ru Yao, Yan Xu, et al.(12912) were purchased from Cell Signaling Technology (Danvers, MA, USA). TLR4 (sc-293072) and Bcl-2 (sc-7382) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA). 2.2 Animals and groups Seven-week-old

(13) The critical role of GRP78/BiP MARylation in ER stress of KRAS-mutant colorectal cancerJCI InsightJanuary 23, 2026Shuxian Zhang, Xiaodan Chen, Qian Gong, Jing Huang, Yi Tang, Ming Xiao, Ming Li, Qingshu Li, Yalan Wang(all Cell Signaling Technology); GRP78/BiP (catalog sc-13539), HSC70 (catalog sc-24), Bcl2 (catalog sc-7382) (all Santa Cruz Biotechnology); p-IRE1α (catalog ab124945), XBP1u/s (catalog ab220783) (both Abcam);

(14) Targeting ST18-mediated pathomechanism in pemphigus vulgaris through voltage-dependent anion channel inhibitionSkin Health and DiseaseJanuary 19, 2026Sari Assaf, Ofer Sarig, Rawaa Ishtewy, Yazeed Zoabi, Yarden Feller, Kiril Malovitski, Janan Mohamad, Shir Bergson, Carmel Bilu, Varda Shoshan-Barmatz, et al.antibody [diluted 1:200; ab15895 (Abcam)] or mouse monoclonal anti-Bcl-2 Antibody (C-2) [diluted 1:50 (sc-7382; Santa Cruz Biotechnology, Santa Cruz, CA, USA)]. Secondary antibody staining was carried out for 1

(15) Nivolumab and bevacizumab attenuate cisplatin-induced hepatic inflammation and apoptosis in ratsHepatology ForumJanuary 15, 2026Ogur Karhan, Sibel Turedisc-52746), IL-6 (Cat. No. sc-28343), VEGF (Cat. No. sc-7269), Bax (Cat. No. sc-7480), Bcl-2 (Cat. No. sc-7382), and Caspase-3 (Cat. No. sc-56053)—were diluted 1:100 and applied to the sections, which were then

(16) Bromo- and chloro-substituted flavones induce apoptosis and modulate cell death pathways in canine lymphoma and leukemia cells - a comparative in vitro studyFrontiers in Molecular BiosciencesJanuary 12, 2026Anita Dudek, Ewa Dejnaka, Joanna Sulecka-Zadka, Martyna Perz, Agnieszka Krawczyk-Łebek, Edyta Kostrzewa-Susłow, Hanna Pruchnik, Aleksandra Pawlakanti-β-actin clone C4 (sc47 778; Santa Cruz Biotechnology, California, USA), dilution 1:2000 and anti-Bcl-2 (sc-7382; Santa Cruz Biotechnology, California, USA), dilution 1:1000. One rabbit monoclonal primary antibody

(17) The PI3K Inhibitor HCD Promotes Caspase Activation in Head and Neck Squamous Cells by Upregulating the Extrinsic and Intrinsic Apoptosis PathwaysJournal of Oral Pathology & MedicineJanuary 1, 2026Leong‐Perng Chan, Ya‐Ping Tseng, Hui‐Ching Wang, Chen‐Yu Chien, Che‐Wei Wu, Ling‐Feng Wang, Tung‐Wen Yen, Po‐Chun Wang, Chih‐Chuang Liaw, Chia‐Hua LiangBax (Santa Cruz Biotechnology, sc‐20067, RRID: AB_626726, 1:200), Bcl‐2 (Santa Cruz Biotechnology, sc‐7382, RRID: AB_626736, 1:200), TNF‐α (Santa Cruz Biotechnology, sc‐33639, RRID: AB_628371, 1:200), TNF‐R1

(18) Monomethyl fumarate confers cardioprotection after myocardial infarction via HCAR2-dependent activation of PI3K/Akt signalingCell Death DiscoveryDecember 30, 2025Yifeng Zhang, Yu Gui, Darrell Belke, Xiaopu Wang, Wen Su, Maojun Liu, Binjie Yan, Jiaxing Sun, Xinqun Hu, Xi-Long Zheng1:1000, Cell Signaling Technology; #9272), Bcl-2 (mouse polyclonal, 1:200, Santa Cruz Biotechnology; #sc-7382), Bax rabbit monoclonal, (1:1000, Cell Signaling Technology; #2772), caspase-3 (full-length, rabbit

(19) Seasonal impact of PM2.5 on pro-oncogenic drivers among participants of a thermal power plant in IndiaScientific ReportsDecember 30, 2025Sukanya Ghosh, Rupa Chaudhuri, Meghna Mukherjee, Lucas Henneman, Priyanka Saha, Anurima Samanta, Subhabrata Dey, Mita Ray Sengupta, Dona Sinha(sc-390916), AKT1/2/3 (sc-81434), EGFR (sc-373746), pPI3K p85αTyr508 (sc-12929), Cyclin D1 (sc-8396), Bcl-2 (sc-7382), VEGF (sc-57496), and PTEN (sc-7974; all from Santa Cruz Biotechnology; 1:1000 dilution), as well as

(20) Effects of Carvacrol on Oxidative Stress and Fibrosis in Streptozotocin-Induced Diabetic Nephropathy: Histological, Gene Expression, and Biochemical InsightsInternational Journal of Molecular SciencesDecember 27, 2025Halime Tuba Canbaz, Mehmet Enes Sozen, Ilknur Cinar Ayan, Hasan Basri Savas, Furkan Adem Canbaz, Gokhan Cuce, Serpil Kalkansections were incubated overnight with Anti-B-cell lymphoma 2 (Bcl-2) (1:500; mouse monoclonal antibody, sc-7382, Santa Cruz Biotechnology, Dallas, TX, USA) and Anti-Bcl-2-associated X protein (Bax) (1:100; mouse

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Bcl-2 (C-2) Antibody

Bcl-2 (C-2) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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Bcl-2 (C-2) Antibody from Santa Cruz Biotechnology, Inc.

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