Bcl-2 (100) Antibody sc-509 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemBcl-2 (100) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-509
NCBI Gene AliasesBcl-2, PPP1R50
Antibody TypePrimary Antibodies
ApplicationsWB, IP, IF, IHC(P), FCM
Quantity200 µg/ml
Clone100
Reactivityhuman
FormatPurified
ClonalityMonoclonal
Hostmouse
Conjugate/TagUnconjugated
NCBI Full Gene NameBCL2 apoptosis regulator
TargetBcl-2
IsotypeIgG1

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Cathepsin A deficiency exacerbates LPS-induced inflammatory liver injury and apoptosisAnim Cells Syst (Seoul)May 21, 2026Hee Young Chae, Ji Yeong Park, Hyejin Hyung, Jiwon Ko, Su-Geun Lim, Young Jin Lee, Myoung Ok Kim, Song Park, Dong Kyu Choi, Soyoung Jang, et al.(1:2000, Santa Cruz Biotechnology, Dallas, TX, USA, sc-7480), Bcl-2 (1:2000, Santa Cruz Biotechnology, sc-509), STAT3 (1:2000, Cell Signaling Technology, 4904), p-STAT3 (1:2000, Cell Signaling Technology, 9145),

(2) Pseudo-senescence induced by palbociclib does not sensitise pleural mesothelioma cells to combinations with senolyticsCell Death DisApril 10, 2026Iswarya Sreeram, Sílvia Plans-Marin, Mabel Cruz-Rodríguez, Elisabet Aliagas, Didac Palau-Gallinat, Cristina Muñoz-Pinedo, Ernest NadalBcl-xL (#2764) and Bcl-W (#2724) were purchased from Cell Signalling Technology (Danvers, MA). Bcl-2 (sc509) and Mcl-1 (sc819) are from Santa Cruz Biotechnology (Dallas, TX) and β-Actin (MAB1501R) was obtained

(3) Pentraxin 3 ameliorates glucocorticoid-induced osteonecrosis of the femoral head via TLR4/NF-κB/FGF21 signaling axisCommunications BiologyDecember 2, 2025Jinxu Li, Zhonghua Zhou, Yan Kong, Yang Li, Zhe Wang, Yongkang Yang, Jingyi Wang, Tianyi Liu, Xinyu Wang, Dan Luo, et al.M20005F, Abmart), PTX3 (1:1000, 13797-1-AP, Proteintech), Bax (1:1000, T40051, Abmart), Bcl-2 (1:500, sc-509, Santa Cruz Biotechnology), Osteocalcin (1:1000 dilution, DF12303, Affinity), ALP (1:1000 dilution,

(4) Therapeutic Effects of Cephalotaxus harringtonia Leaf Extract on Hepatocellular Carcinoma via Regulation of the Intrinsic Apoptosis Pathway and Cell CycleCurrent Issues in Molecular BiologyNovember 27, 2025Dae-Han Park, Sonny C. Ramos, Hyun Bo Sim, Ju-Bin Lee, Ho-Yeol Jang, Beom-Gyun Jeong, Kyung-Wuk Park, Kyung-Yun Kang, Jong-Jin Kim(clone B-9; Santa Cruz Biotechnology, Santa Cruz, CA, USA); and PE-conjugated anti-BCL-2 antibody (clone SC-509; Santa Cruz Biotechnology, Santa Cruz, CA, USA). The following cell lines were used in this study: human

(5) Growth Hormone Effects on Hypoxia-Induced Neuroinflammation in the Developing CerebellumInternational Journal of Molecular SciencesNovember 1, 2025Rosario Baltazar-Lara, Martha Carranza, Carlos G. Martínez-Moreno, José Ávila-Mendoza, Carlos Arámburo, Maricela Luna,Cell Signaling,9106S pAkt,Rabbit/monoclonal,1:1000 WB,Cell Signaling,92715 Bcl-2,Mouse/monoclonal,1:1000 WB,Santa Cruz,Sc-509 pNFkB,Rabbit/monoclonal,1:1000 WB,Cell Signaling,3033S CD86,Rabbit/polyclonal,1:1000 WB,Abcam,Ab112490 CD206,Rabbit/polyclonal,1:1000

(6) KLHL5 Contributes to Colorectal Cancer Cell Survival by Promoting Cell Cycle Progression and Suppressing Apoptotic Cell DeathCancer ScienceSeptember 1, 2025Kyosuke Habu, Yosuke Matsuoka, Hiromi Hiyoshi, Jun Nakayama, Katsuya Watanabe, Sota Tate, Tomohisa Sakaue, Junko Murai, Konomu Uno, Hirotada Nishie, et al.anti‐KLHL5 (1:2000 dilution for western blotting; sc‐515745, #1516) and mouse anti‐Bcl‐2 (1:3000 dilution; sc‐509, #E1005) and rabbit anti‐Vimentin (1:500 dilution; sc‐7557‐R) antibodies were purchased from Santa Cruz Biotechnology

(7) p53 Protein Stability Plays a Crucial Role in NaB-Mediated Apoptosis in Colorectal Cancer CellsCurrent Issues in Molecular BiologyJuly 22, 2025Jeong Yeon Lee, Hyunju Kimanti-caspase 3 (Cell Signaling, Danver, MA, USA, cs-9662, 1:200), anti-Bcl-2 (Santa Cruz Biotechnology, sc-509, 1:500), anti-Bax (Santa Cruz Biotechnology, sc-7480, 1:500), anti-γ-H2AX (Santa Cruz Biotechnology,

(8) The cancer-associated SF3B1K700E spliceosome mutation confers enhanced sensitivity to BV-6-induced cytotoxicityCell Death DisJuly 1, 2025Lydia E. Roets, Jaine K. Blayney, Hayley P. McMillan, Patrick J. Preston, Alexander M. Mutch, Ken I. Mills, Kienan I. Savage, Katrina M. Lappin(Thermo Fisher Scientific) and blotted using the following antibodies: NF-κB2 p52/p100 (sc-7386), BCL-2 (sc-509), and β-actin (sc-47778) from Santa Cruz Biotechnology; Caspase-8 (ALX-804-242-C100, Enzo); cIAP1 (10022-1-AP,

(9) Targeting the p53/xCT/GSH Axis with PRIMA-1Met Combined with Sulfasalazine Shows Therapeutic Potential in Chronic Lymphocytic LeukemiaInt J Mol SciJune 10, 2025Martina Pasino, Andrea Speciale, Silvia Ravera, Giovanna Cutrona, Rosanna Massara, Nadia Bertola, Maurizio Viale, Irena Velkova, Andrea Nicola Mazzarello, Franco Fais, et al.Santa Cruz Biotechnology), anti-P21 Waf1/Cip1 (DCS60 #2946 Cell Signaling Technology, Danvers, MA, USA), anti-Bcl-2 (sc-509, Santa Cruz Biotechnology) anti-cystine/glutamate transporter (SLC7A11/xCT; Clone D2M7A, #12691 Cells

(10) Synurus deltoides Alleviates Anti-Depressive Like Behavior Dysfunction Induced by Chronic Unpredictable Mild Stress via Stress-Related CRF/TLR PathwayJ Microbiol BiotechnolMay 15, 2025Seung Gyum Joo, Jong Min Kim, Hyo Lim Lee, Min Ji Go, Tae Yoon Kim, Ju Hui Kim, Han Su Lee, Hyun Ji Eo, Hyun-Jin Kim, Ho Jin Heo(USA) TNF-α,sc-33639,1:1000,"Santa Cruz Biotechnology, Inc." IL-1β,sc-515598,1:500,"Santa Cruz Biotechnology, Inc." BCl-2,sc-509,1:1000,"Santa Cruz Biotechnology, Inc." Bax,sc-7480,1:2000,"Santa Cruz Biotechnology, Inc." Caspase-3,CSB-PA05689A0Rb,1:1000,"Cusabio

(11) ob/ob obese mice promote tumorigenesis of endometrial cancer associated with Pten deficiencyEndocrine-Related CancerMay 1, 2025Keun Cheon Kim, Amanda Hull, Eric Johannsen, Mark I. Hunter, Tae Hoon Kim, Jae-Wook JeongPhospho-Akt (Ser473) (pAKT)(CS-4060, Cell Signaling), 1:200 for B-cell leukemia / lymphoma 2 (BCL2)(SC-509, Santa Cruz Biotechnology, Dallas, TX), 1:500 for insulin receptor substrate 1 (IRS1) (ab131487, Abcam),

(12) Salinomycin and oxaliplatin synergistically enhances cytotoxic effect on human colorectal cancer cells in vitro and in vivoSci RepApril 23, 2025Fang Liu, Rongbin Lv, Xiaowen Qiao, Geng Lv, Haipeng Yuan, Jianguo Han, Xiaohong Wang, Jie Wan, Min Wangantibody (MA5‑15173) was obtained from Invitrogen. Antibodies against cytochrome c (sc-13561), Bcl-2 (sc-509) and Bax (sc-20067) were obtained from Santa Cruz. An Annexin V‑fluorescein isothiocyanate (FITC)/propidium

(13) Methyl alcohol extract of marine green alga Enteromorpha linza (Linnaeus) J. Agardh. induces reactive oxygen species-dependent growth arrest and apoptosis in human hepatocellular carcinoma Hep3B cellsNutr Res PractMarch 31, 2025Eun Ok Choi, Gi-Young Kim, Hye-Jin Hwang, Yung Hyun Choi,Santa Cruz Biotechnology,sc-8007,"1:1,000" Bax,"Proteintech Group, Inc.",50599-2-Ig,"1:1,000" Bcl-2,Santa Cruz Biotechnology,sc-509,"1:1,000" Cytochrome c,Cell Signaling Technology,4280S,1:500 COX IV,Santa Cruz Biotechnology,sc-517553,"1:1,000" Actin,BioWorld

(14) ob/ob obese mice promote tumorigenesis of endometrial cancer associated with Pten deficiencyEndocr Relat CancerMarch 27, 2025Keun Cheon Kim, Amanda Hull, Eric Johannsen, Mark I. Hunter, Tae Hoon Kim, Jae-Wook JeongPhospho-Akt (Ser473) (pAKT)(CS-4060, Cell Signaling), 1:200 for B-cell leukemia / lymphoma 2 (BCL2)(SC-509, Santa Cruz Biotechnology, Dallas, TX), 1:500 for insulin receptor substrate 1 (IRS1) (ab131487, Abcam),

(15) Cepharanthine hydrochloride: a novel ferroptosis-inducing agent for prostate cancer treatmentFrontiers in PharmacologyFebruary 24, 2025Jing-Song Guan, Jing Jia, Ze-Xiu Huang, Yu-Qing Zhou, Jing-Jie Zheng, Qi-Man Lin, Yi-Fei Wang, Jiang-Lin Fan, Yao WangCell Signaling Technology (Bost on, MA, United States). PARP (sc-8007), cleaved-PARP (sc-56196), Bcl-2 (sc-509), Caspase-3 (sc-56053), P62 (sc-28359), ATG5 (sc-133158), FSP1 (sc-377120), GPX4 (sc-166570), and AR

(16) Implication of endoplasmic reticulum stress and mitochondrial perturbations in remote liver injury after renal ischemia/reperfusion in rats: potential protective role of azilsartanRedox ReportDecember 31, 2024Rania A. Elrashidy, Esraa M. Zakaria, Rehab A. Hasan, Asmaa M. Elmaghraby, Dina A. Hassan, Ranya M. Abdelgalil, Shaimaa R. Abdelmohsen, Amira M. Negm, Azza S. Khalil, Ayat M. S. Eraque, et al.immunohistochemical staining using mouse monoclonal antibodies (dilution 1:100; Santa Cruz Biotechnology Inc, Texas, USA; # sc-509 and sc-7480, respectively). Briefly, the slides were deparaffinized followed by antigen retrieval. To

(17) A novel role for nonactin: interfering with G-quadruplex in RET-driven medullary thyroid cancerBMC CancerDecember 23, 2024Tariq Alqahtani, Arwa Alsubait, Meshari Aloumi, Abdulrahman Alamer, Ghala Alomari, Osama I. Alwassil, Ahmad J. Obaidullah, Sahar S. AlghamdiCell Signaling, Beverly, MA, USA; anti-cyclin E (sc-247), E2F1 (sc-56661), cyclin D (sc-20044), and BCL-2 (sc-509), from Santa Cruz Biotechnology; Additionally, anti-actin (ab8227) was purchased from Abcam. As secondary

(18) BH3-mimetics or DNA-damaging agents in combination with RG7388 overcome p53 mutation-induced resistance to MDM2 inhibitionApoptosisDecember 1, 2024N. V. Pervushin, D. K. Nilov, S. V. Pushkarev, V. O. Shipunova, A. S. Badlaeva, M. A. Yapryntseva, D. V. Kopytova, B. Zhivotovsky, G. S. Kopeinaantibodies were used: anti-poly (ADP-ribose)-polymerase (PARP, ab137653) (Abcam, Cambridge, UK), anti-Bcl-2 (sc-509) (Santa Cruz Biotechnology, Dallas, TX, USA), anti-p53 (P6874-200UL, Sigma, Saint Louis, MO, USA), anti-PARP

(19) TAp73 regulates mitochondrial dynamics and multiciliated cell homeostasis through an OPA1 axisCell death & diseaseNovember 8, 2024Buckley NA, Craxton A, Sun XM, Panatta E, Pinon LG, Beier S, Kalmar L, Llodrá J, Morone N, Amelio I, et al.TotalOXPHOS Cocktail,Abcam,Ab110411,Mouse,1:1000 MCL-1,Rockland,600-401-394,Rabbit,1:1000 BCL2,Santa-Cruz,Sc-509,Mouse,1:200 BCL-xL,Genetex,GTX100064,Rabbit,1:1000 Vinculin,Abcam,Ab18058,Mouse,1:5000 A list of

(20) Saikosaponin‐b2 Regulates the Proliferation and Apoptosis of Liver Cancer Cells by Targeting the MACC1/c‐Met/Akt Signalling PathwayAdvances in Pharmacological and Pharmaceutical SciencesNovember 6, 2024Yanxue Zhu, Xingzhi Lv, Ruifang Li, Zihan Gao, Chanhao Lei, Lan Wang, Sanqiang Lixenograft mice. 2. Materials and Methods 2.1. Antibodies and Reagents Antibodies against Bcl-2 (sc-509), Bax (sc-7480), Cyt-c (sc-13156), cleaved caspase 9 (sc-17784) and cleaved caspase 3 (sc-271759) were

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Bcl-2 (100) Antibody

Bcl-2 (100) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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Bcl-2 (100) Antibody from Santa Cruz Biotechnology, Inc.

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