The Lamin B Receptor Polyclonal Antibody, RBITC Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to Lamin B Receptor, and LBR. This antibody recognizes Homo Sapiens, Human, and Mouse antigen. The Lamin B Receptor Polyclonal Antibody, RBITC Conjugated has been shown to work in the following applications: Flow Cytometry, and Western Blot.
Description
Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization. Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. The cleavage of lamins results in nuclear disregulation and cell death