Bioss Inc.'s IL-1R1 (Tyr496) Polyclonal Antibody, PE-Cy7 Conjugated is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Flow Cytometry, and Western Blot. The IL-1R1 (Tyr496) Polyclonal Antibody, PE-Cy7 Conjugated was generated using IL1R1 as the antigen and it reacts with Homo Sapiens, Human, and Mouse.
Description
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex