Bioss Inc.'s CDKN1A Polyclonal Antibody, PE-Cy7 Conjugated is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The CDKN1A Polyclonal Antibody, PE-Cy7 Conjugated was generated using CDKN1A, and CDKN1A as the antigen and it reacts with Homo Sapiens, Human, Mouse, and Rat.
Description
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity)