Bioss Inc.'s Caspase-10 Polyclonal Antibody, PE Conjugated is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Immunohistochemistry - frozen. The Caspase-10 Polyclonal Antibody, PE Conjugated was generated using CASP10, and Caspase 10 as the antigen and it reacts with Homo Sapiens, and Human.
Description
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-:-AMC and Asp-Glu-Val-Asp-:-AMC. Isoform C is proteolytically inactive