The Histone H2A.X (Ser140) Antibody, PE-Cy7 Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to H2A.X variant histone, and H2AX. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The Histone H2A.X (Ser140) Antibody, PE-Cy7 Conjugated has been shown to work in the following applications: Flow Cytometry, and Western Blot.
Description
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation