The PI3 kinase p85 alpha + gamma (Tyr467 + Tyr199) antibody, RBITC Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to PIK3R1. This antibody recognizes Homo Sapiens, Human, and Rat antigen. The PI3 kinase p85 alpha + gamma (Tyr467 + Tyr199) antibody, RBITC Conjugated has been shown to work in the following applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, Immunohistochemistry - frozen, and Western Blot.
Description
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p11 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling