The AKT1/2/3 (Ser472/Ser473/Ser474) Antibody, RBITC Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to AKT1. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The AKT1/2/3 (Ser472/Ser473/Ser474) Antibody, RBITC Conjugated has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, Immunohistochemistry - frozen, and Western Blot.
Description
AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation