Jak3 (D7B12) Rabbit mAb 8863S from Cell Signaling Technology

Product Specs
ItemJak3 (D7B12) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number8863S
ClonalityMonoclonal
NCBI Full Gene NameJanus kinase 3
Research AreaImmunology and Inflammation
IsotypeIgG
CloneD7B12
Molecular Weight115
ReactivityHu, Ms, Rt
ApplicationsWestern Blot (WB)
NCBI Gene AliasesJAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
HostRabbit
TargetJak3
Quantity100 µl

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) The E3 ligases Itch and WWP2 regulate autoimmune neuroinflammation by controlling TH2 to TH17 cell conversion via interleukin-4-STAT5 axis in miceNature CommunicationsJanuary 23, 2026Mei Zhao, Chao Zhang, Xin Zhang, Qingdian Mu, Qian Li, Yun-Cai Liu1:2000), Jak3 phosphorylated at Tyr980 and Tyr981 (clone D44E3, #5031, 1:1000), Jak3 (clone D7B12, #8863, 1:2000), p44/42 MAPK (Erk1/2) phosphorylated at Thr202 and Tyr204 (clone D13.14.4E, #4370, 1:1000),

(2) Myeloid-specific HNRNPA2B1 deficiency disrupts macrophage function and in vivo responsesThe Journal of ImmunologyAugust 1, 2025Mays Mohammed Salih, Chi G Weindel, Eric Malekos, Lisa Sudek, Sol Katzman, Cory J Mabry, Morgan J Chapman, Aja K Coleman, Sikandar Azam, Robert O Watson, et al.,Santa Cruz Biotechnology,Sc-374053 pSTAT3,Cell Signaling,9138S STAT3,Cell Signaling,9139S pJAK3,Cell Signaling,5031S JAK3,Cell Signaling,8863S Horseradish peroxidase–conjugated β-actin,Santa Cruz Biotechnology,Sc-47778 HNRNPL,Santa Cruz Biotechnology,Sc-32317 GAPDH,Santa Cruz Biotechnology

(3) RAB32 promotes glioma cell progression by activating the JAK/STAT3 signaling pathwayJournal of International Medical ResearchDecember 4, 2024Sinan Zhang, Xudong Jiang, Qing Wei, Liji Huang, Zhuoyan Huang, Lina Zhang(HA721182, Haobio, 1:1000), STAT3 (9139S, CST, MA, USA, 1:2000), p-STAT3 (5031S, CST, 1:2000), JAK3 (8863S, CST, 1:1000), p-JAK3 (5031S, CST, 1:1000), and GAPDH (TA-08, Zsbio, Beijing, China, 1:1000). Subsequently,

(4) Bmal1 haploinsufficiency impairs fear memory and modulates neuroinflammation via the 5-HT2C receptorFrontiers in PharmacologyNovember 14, 2024Weifen Li, Shengnan Mou, Tahir Ali, Tianxiang Li, Yan Liu, Shupeng Li, Xiaoming Yu, Zhi-Jian Yu,Cell Signaling Technology,#3230,1:1000 p-JAK3,Cell Signaling Technology,#5031,1:1000 JAK3,Cell Signaling Technology,#8863,1:1000 p-STAT1(Ser727),Cell Signaling Technology,#8826,1:1000 STAT1,Proteintech,10144-2-AP,1:1000 p-STAT3(Ser705),Cell Signaling Technology

(5) Rhoifolin Attenuates Concanavalin A-Induced Autoimmune Hepatitis in Mice via JAKs/STATs Mediated Immune and Apoptotic ProcessesACS OmegaOctober 22, 2024Ge Zhao, Hu Qi, Minghua Liu, Ting Zhou, Li Chen, Chunhong Wu, Xiongwei Zhang, Nan Zeng, Yue Tongthe antibodies specific to cleaved caspase-3 (#9664), cleaved caspase-9 (#9509), JAK2 (#3230), JAK3 (#8863), and BNIP3 (#3769) were obtained from Cell Signaling Technology (MA, USA). STAT1 (#AF6300), p-STAT1

(6) Cannabidiol Alleviates Imiquimod-Induced Psoriasis by Inhibiting JAK2–STAT3 in a Mouse ModelBiomedicinesSeptember 12, 2024Min-Seo Kim, Ji-Hyun Lee, Sae-Woong Kim, Chul-Hwan Bang,Cell Signaling Technology® WB/IHC,P-STAT3,1:1000/1:200,#9145,Cell Signaling Technology® WB/IHC,JAK2,1:1000,#3230,Cell Signaling Technology® WB,JAK3,1:1000,#8863,Cell Signaling Technology® WB,Goat Anti-Mouse IgG antibody (HRP),1:4000,GRX213111-01,GeneTex WB,Goat

(7) Loss of tumor suppressors promotes inflammatory tumor microenvironment and enhances LAG3+T cell mediated immune suppressionNature communicationsJuly 12, 2024Zahraeifard S, Xiao Z, So JY, Ahad A, Montoya S, Park WY, Sornapudi T, Andohkow T, Read A, Kedei N, et al.9361S), STAT6 (Cell Signaling, #9362S), pJAK3 (Cell Signaling, #5031S, D44E3), JAK3 (Cell Signaling, #8863S, D7B12), or β-actin (Santa Cruz, sc-69879, AC-15). Primary antibodies were diluted in 1:1000. Secondary

(8) TCF-1 regulates NKG2D expression on CD8 T cells during anti-tumor responsesCancer immunology, immunotherapy : CIIJune 1, 2023Harris R, Mammadli M, Hiner S, Suo L, Yang Q, Sen JM, Karimi M.(Cell Signaling Technology #9107), JAK 2(Cell Signaling Technology # 3230), JAK3 (Cell Signaling Technology #8863), STAT3 (Cell Signaling Technology #9139), p65-Rela (Cell Signaling Technology #4764), AKT (Cell Signaling Technology

(9) A Rapid Translational Immune Response Program in CD8 Memory T LymphocytesThe Journal of ImmunologySeptember 15, 2022Darin Salloum, Kamini Singh, Natalie R. Davidson, Linlin Cao, David Kuo, Viraj R. Sanghvi, Man Jiang, Maria Tello Lafoz, Agnes Viale, Gunnar Ratsch, et al.Notch-1(3608S), Stat6 (5397S), Shmt2 (33443), eEf2 (2332S), phosphor-Jak family Ab sampler Kit (97999T), Jak3 (8863S) purchased from Cell Signaling Technology, Il2rb (PA5–86323), Ifngr1 (PA5–96413) purchased from ThermoFisher,

(10) Inhibitory effects of superoxide dismutase 3 on IgE production in B cellsBiochemistry and biophysics reportsMarch 1, 2022Agrahari G, Sah SK, Lee MJ, Bang CH, Kim YH, Kim HY, Kim TY.P-JAK1 (3331S, Cell Signaling), JAK1 (3332S, Cell Signaling), P-JAK3 (5031S, Cell Signaling), JAK3 (8863S, Cell Signaling) P-STAT6 (9361S, Cell Signaling), STAT6 (9362S, Cell Signaling), p-NF-κBp65 (SC-136548,

(11) Therapeutic siRNAs Targeting the JAK/STAT Signalling Pathway in Inflammatory Bowel DiseasesJournal of Crohn's and ColitisFebruary 23, 2022Flora Clément et al.#9175" JAK2,1:1000,Cell Signaling Technology,#3229 JAK3,1:1000,Cell Signaling Technology,"#3775, #5481, #8863s" TYK2,1:1000,Cell Signaling Technology,#9312s P-STAT1,1:1000,Cell Signaling Technology,#9167 P-STAT2,1:1000,Cell Signaling Technology

(12) Suppression of NLRP3 Inflammasome by Dihydroarteannuin via the HIF-1α and JAK3/STAT3 Signaling Pathway Contributes to Attenuation of Collagen-Induced Arthritis in MiceFrontiers in pharmacologyJanuary 1, 2022Zhang M, Wu D, Xu J, Liu L, Jiao W, Yu J, Chen G.The primary antibodies against STAT3 (Cat. No. 9139), Phospho-STAT3 (Cat. No. 9145), JAK3 (Cat. No. 8863), Phospho-JAK3 (Cat. No. 5031), and GAPDH (Cat. No. 2858) were purchased from Cell Signaling Technology.

(13) Mannan-Binding Lectin Regulates the Th17/Treg Axis Through JAK/STAT and TGF-β/SMAD Signaling Against Candida albicans InfectionJournal of inflammation researchJanuary 1, 2022Wang F, Yang Y, Li Z, Wang Y, Zhang Z, Zhang W, Mu Y, Yang J, Yu L, Wang M.(5339S), p-SMAD2Ser465+467 (3108S), SMAD3 (9523S), p-SMAD3Ser423+Ser425 (9520S), JAK2 (3230S), JAK3 (8863S), and p-JAK3Tyr980/981 (5031S) were purchased from Cell Signaling Technology; the antibody against SMAD7

(14) A piggyBac-based platform for genome editing and clonal rhesus macaque iPSC line derivationScientific reportsJuly 29, 2021Rodriguez-Polo I, Mißbach S, Petkov S, Mattern F, Maierhofer A, Grządzielewska I, Tereshchenko Y, Urrutia-Cabrera D, Haaf T, Dressel R, et al.(Cell Signalling OCT4-A C52G3, 1:1000), NANOG (Cell Signalling D73G4, 1:400), TRA-1-60 (eBioscience 14-8863, 1:50) and LIN28 (Cell Signalling A177, 1:100) primary antibodies were used for the detection of undifferentiated

(15) Boundary layer structure characteristics under objective classification of persistent pollution weather types in the Beijing areaAtmospheric Chemistry and PhysicsJune 11, 2021Zhaobin Sun, Xiujuan Zhao, Ziming Li, Guiqian Tang, Shiguang Miaofield among the four types can be summarized as follows. The average relahttps://doi.org/10.5194/acp-21-8863-2021 tive humidity below 1000 m is higher than that above 1000 m. The inverse relative humidity structure

(16) Janus Kinase 3 Deficiency Promotes Vascular Reendothelialization-Brief ReportArteriosclerosis, thrombosis, and vascular biologyJune 1, 2021Wang YC, Cai D, Cui XB, Chuang YH, Fay WP, Chen SY.(R&D, 220-BB). Antibodies Antibodies were obtained from the following sources: JAK3 (Cell Signaling, #8863), phospho-JAK3 (Santa Cruz, sc-16567), SMMHC (Abcam, ab53219), α-SMA (Abcam, ab5694), CNN1 (Cell signaling,

(17) Curcumin Nanoparticle Enhances the Anticancer Effect of Cisplatin by Inhibiting PI3K/AKT and JAK/STAT3 Pathway in Rat Ovarian Carcinoma Induced by DMBAFrontiers in PharmacologyJanuary 18, 2021Ni Made Dwi Sandhiutami, Wawaimuli Arozal, Melva Louisa, Deni Rahmat, Puspita Eka Wuyungantibody (CST#9272), p-Akt antibody (Ser473) (D9E) XP® Rabbit mAb (CST#4060), JAK3 (D7B12) Rabbit mAb (CST#8863), STAT3 (D3Z2G) Rabbit mAb (CST#12640), phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit mAb (CST#9145), Anti

(18) Anti-inflammatory effects of natural flavonoid diosmetin in IL-4 and LPS-induced macrophage activation and atopic dermatitis modelInternational immunopharmacologyDecember 1, 2020Lee DH, Park JK, Choi J, Jang H, Seol JW.(3344, Cell Signaling Technology), anti-phospho-JAK1 (74129, Cell Signaling Technology), anti-JAK3(8863, Cell Signaling Technology), anti-phospho-JAK3 (5031, Cell Signaling Technology), anti-STAT6(5397, Cell Signaling Technology

(19) Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na⁺/K⁺-ATPase independent proteolysisBiochemical pharmacologyOctober 1, 2020Yang CW, Hsu HY, Chang HY, Lee YZ, Lee SJ.1:1000), JAK2 (catalog # 3230, 1:1000), p-JAK3 (Y980/981) (catalog # 5031, 1:1000), JAK3 (catalog # 8863, 1:1000), TYK2 (catalog # 9312, 1:1000), p-TYK2 (Y1054/1055) (catalog # 9321, 1:1000), and glyceraldehyde

(20) High-fat diet intensifies MLL-AF9-induced acute myeloid leukemia through activation of the FLT3 signaling in mouse primitive hematopoietic cellsScientific reportsSeptember 30, 2020Hermetet F, Mshaik R, Simonet J, Callier P, Delva L, Quéré R.detect FLT3 (PA5-34448, Thermo Fisher Scientific) or ACTB (612656, BD Biosciences). We used JAK3 (#8863), phosphoJAK3 (Y980/981) (#5031), STAT5 (#94205), phospho-STAT5 (Y694) (#9359), STAT3 (#4904), phospho-STAT3 (Y705)

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Jak3 (D7B12) Rabbit mAb

Jak3 (D7B12) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Jak3 (D7B12) Rabbit mAb from Cell Signaling Technology

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