Rabbit anti-MSH2 IHC Antibody, Affinity Purified IHC-00082 from Bethyl Laboratories, Inc.

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Gut
December 01 2015

Fig 1: Mesalazine (5-ASA) and thymoquinone (TQ) reduce microsatellite instability (MSI) in microdissected tissue. (A) Raw data from a dinucleotide and a poly-A mononucleotide marker visualised with GeneMapper software. Major allele sizes of normal intestinal epithelium and tumour cells were compared with tail DNA. MSI was reduced by 5-ASA and TQ in Msh2-deficient epithelium. MSI quantification by number of mutations per marker (NMPM) in Msh2-deficient epithelium (B) and tumour cells (C). Significance was illustrated as *p<0.05, **p<0.01.
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Gut
December 01 2015

Fig 2: Genotyping of conditional Msh2 knock-out. (A) Genotyping of tail DNA for conditional knock-out of exon 12 of the Msh2 gene. DNA from wildtype mice gave a 210 base pair product, whereas transgenic mice (#1–7) yielded a 405 base pair product. (B) Expression of Cre recombinase in nuclei of intestinal epithelial cells of Msh2loxP/loxP Villin-Cre mice. (C) Msh2 expression is depleted in intestinal epithelial cells but not in pancreatic tissue and lamina propria (arrow) from Msh2loxP/loxP Villin-Cre mice (left). (D) Control mice (wildtype) express Msh2 mainly in the crypts.

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Rabbit anti-MSH2 IHC Antibody, Affinity Purified

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Bethyl Laboratories, Inc.'s Rabbit anti-MSH2 IHC Antibody, Affinity Purified is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry. The Rabbit anti-MSH2 IHC Antibody, Affinity Purified was generated using MSH2 as the antigen and it reacts with Homo Sapiens, Human, and Mouse.

Description

The epitope recognized by IHC-00082 maps to a region between residue 875 and the C-terminus (residue 934) of human mutS homolog 2 using the numbering given in Swiss-Prot entry P43246 (GeneID 4436)

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Rabbit anti-MSH2 IHC Antibody, Affinity Purified from Bethyl Laboratories, Inc.

Description

Bethyl Laboratories, Inc.

Citations (1)

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Rabbit anti-MSH2 IHC Antibody, Affinity Purified from Bethyl Laboratories, Inc.

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